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The protein encoded by CTGF is a mitogen that is secreted by vascular endothelial cells. Additionally we are shipping CTGF Proteins (79) and CTGF Kits (78) and many more products for this protein.
Showing 10 out of 236 products:
Human Polyclonal CTGF Primary Antibody for IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
Show all 3 references for ABIN672636
Human Polyclonal CTGF Primary Antibody for ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 3 references for ABIN152147
Human Monoclonal CTGF Primary Antibody for IHC (fro), IHC (p) - ABIN111993
Schwab, Postler, Nguyen, Mittelbronn, Meyermann, Schluesener: Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction. in Neuropathology and applied neurobiology 2000
Show all 2 references for ABIN111993
Human Polyclonal CTGF Primary Antibody for IHC, IHC (p) - ABIN4300783
Livingston, Ding, Huang, Hill, Yin, Dong: Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. in Autophagy 2016
Human Monoclonal CTGF Primary Antibody for ELISA, WB - ABIN514745
Polacek, Bruun, Johansen, Martinez: Comparative Analyses of the Secretome from Dedifferentiated and Redifferentiated Adult Articular Chondrocytes. in Cartilage 2015
Human Polyclonal CTGF Primary Antibody for IHC (p), WB - ABIN392204
Li, Sanchez, Pappalardo, Lynch, Hla, Ferrer: Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. in Molecular cancer research : MCR 2008
Human Polyclonal CTGF Primary Antibody for WB - ABIN223605
Chen, Lan, Zhou, Li, Zhang, Zhang, Yang, Li: Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. in Planta medica 2011
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf (show VEGFA Antibodies) gene expression is regulated by CTGF and ROCK2 (show ROCK2 Antibodies).
these results suggested that loss of miR (show MLXIP Antibodies)-30c may contribute to the pathogenesis of diabetic nephropathy (DN) by inhibiting target CTGF expression; replenishing miR (show MLXIP Antibodies)-30c may ameliorate renal structure and function by reducing renal fibrosis in DN.
Data suggest that PTEN (show PTEN Antibodies) phosphatase (PTEN (show PTEN Antibodies)) regulates renal extracellular matrix production via activated protein kinase B (Akt (show AKT1 Antibodies)) and increased connective tissue growth factor (CTGF) in diabetes mellitus.
Under physiological conditions, CCN2 may be regulating the levels of free amino acids in the extracellular matrix of cartilage.
These data indicate that LPA increases CCN2 expression through the activation of PKC (show PKC Antibodies) and PKA. Thus, the regulatory functions of the PKC (show PKC Antibodies) and PKA pathways are implicated in the LPA-induced increase in CCN2 expression
CTGF inhibition may benefit patients with dilated cardiomyopathy.
These results suggest that TGF-beta1 (show TGFB1 Antibodies) and CTGF may be involved in the process of denervated skeletal muscle fibrosis.
RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix.
CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.
In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA (show RHOA Antibodies) activation, the activation of the serum response factor, and the expression and secretion of CTGF.
Study shows the role of the CTGF gene as a target of miR (show MLXIP Antibodies)-18a, and identifies the function of HBV/HBX/miR (show MLXIP Antibodies)-18a/CTGF as a key signaling pathway mediating HBV infection-induced HCC (show FAM126A Antibodies).
CTGF expression is significantly upregulated in human masticatory mucosa during wound healing
TGF-beta1 (show TGFB1 Antibodies), in association with the increased expression of CTGF, contribute to the homeostasis of the extracellular matrix and to the hypertrophy of ligamentum flavum through the p38 MAPK (show MAPK14 Antibodies) pathway.
The present study aimed to examine the clinical relevance of NOV (show NOV Antibodies) along with CYR61 (show CYR61 Antibodies) and CTGF in gastric cancer by analysing their transcript levels...the expression of NOV (show NOV Antibodies) and CYR61 (show CYR61 Antibodies) was increased in gastric cancer. The elevated expression of CYR61 (show CYR61 Antibodies) was associated with poorer survival. NOV (show NOV Antibodies) promoted proliferation and invasion of gastric cancer cells
Authors found that CTGF is always associated with haemosiderin-pigmented macrophage-like cells, which suggests that CTGF is produced by synovial A cells following the uptake of blood breakdown products.
Decreased expression of CTGF is a common feature in Non Small Cell Lung Cancer; however, it can be restored by the chromatin-modifying agents such as 5-dAzaC or TSA (show PRDX2 Antibodies) and consequently restrain cancer development.
our present findings indicate that the CTGF/p38 (show CRK Antibodies) axis is a novel therapeutic target of NSCLC metastasis, particularly NSCLC secreting low levels of CTGF.
miR (show MLXIP Antibodies)-143-3p inhibits hypertrophic scarring by regulating the proliferation and apoptosis of human HSFs, inhibiting ECM (show MMRN1 Antibodies) production-associated protein expression by targeting CTGF, and restraining the Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.
Plasma CTGF levels were significantly higher in pulmonary arterial hypertension associated with congenital heart disease than in those with CHD (show CHDH Antibodies) and healthy volunteers
Connective tissue growth factor (CTGF) was found to be overrepresented in most significant enriched pathways and was experimentally confirmed as a bona fide target of miR (show MLXIP Antibodies)-18a, which modulated cell migration and proliferation of human corneal epithelial cells.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Antibodies) but newly induced that of decorin (show DCN Antibodies) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
A significant increase in TGF-beta1 (show TGFB1 Antibodies) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Antibodies) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Antibodies)-, GFAP (show GFAP Antibodies)-and GFAP (show GFAP Antibodies)/Nestin (show NES Antibodies)-positive cells, activated p44 (show GTF2H2 Antibodies)/42 signaling, and upregulated fibronectin (show FN1 Antibodies). In human glioma cells, it induced GFAP (show GFAP Antibodies) and nestin (show NES Antibodies).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Antibodies) pathway, in accord with its ability to bind to the Wnt (show WNT2 Antibodies) co-receptor LDL receptor (show LDLR Antibodies)-related protein 6 (LRP6 (show LRP6 Antibodies)).
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
WNT1 inducible signaling pathway protein 2
, connective tissue growth factor
, Connective tissue growth factor
, connective tissue growth factor-like
, CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor XCTGF