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The protein encoded by CTGF is a mitogen that is secreted by vascular endothelial cells. Additionally we are shipping CTGF Proteins (71) and CTGF Kits (70) and many more products for this protein.
Showing 10 out of 233 products:
Human Polyclonal CTGF Primary Antibody for IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
Show all 3 references for ABIN672636
Human Polyclonal CTGF Primary Antibody for ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 3 references for ABIN152147
Human Monoclonal CTGF Primary Antibody for IHC (fro), IHC (p) - ABIN111993
Schwab, Postler, Nguyen, Mittelbronn, Meyermann, Schluesener: Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction. in Neuropathology and applied neurobiology 2000
Show all 2 references for ABIN111993
Human Monoclonal CTGF Primary Antibody for ELISA, WB - ABIN514745
Polacek, Bruun, Johansen, Martinez: Comparative Analyses of the Secretome from Dedifferentiated and Redifferentiated Adult Articular Chondrocytes. in Cartilage 2015
Human Polyclonal CTGF Primary Antibody for IHC (p), WB - ABIN392205
Li, Sanchez, Pappalardo, Lynch, Hla, Ferrer: Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. in Molecular cancer research : MCR 2008
Human Polyclonal CTGF Primary Antibody for WB - ABIN223605
Chen, Lan, Zhou, Li, Zhang, Zhang, Yang, Li: Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. in Planta medica 2011
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
these results suggested that loss of miR (show MLXIP Antibodies)-30c may contribute to the pathogenesis of diabetic nephropathy (DN) by inhibiting target CTGF expression; replenishing miR (show MLXIP Antibodies)-30c may ameliorate renal structure and function by reducing renal fibrosis in DN.
Data suggest that PTEN (show PTEN Antibodies) phosphatase (PTEN (show PTEN Antibodies)) regulates renal extracellular matrix production via activated protein kinase B (Akt (show AKT1 Antibodies)) and increased connective tissue growth factor (CTGF) in diabetes mellitus.
Under physiological conditions, CCN2 may be regulating the levels of free amino acids in the extracellular matrix of cartilage.
These data indicate that LPA increases CCN2 expression through the activation of PKC (show PKC Antibodies) and PKA. Thus, the regulatory functions of the PKC (show PKC Antibodies) and PKA pathways are implicated in the LPA-induced increase in CCN2 expression
CTGF inhibition may benefit patients with dilated cardiomyopathy.
These results suggest that TGF-beta1 (show TGFB1 Antibodies) and CTGF may be involved in the process of denervated skeletal muscle fibrosis.
RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix.
CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.
In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA (show RHOA Antibodies) activation, the activation of the serum response factor, and the expression and secretion of CTGF.
these findings reveal a key role of the SRF/CTGF/miR (show MLXIP Antibodies)-133a axis in the regulation of cardiac fibrosis
CTGF plays a crucial role in the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis (RA) and probably contributes to synovial lining cell hyperplasia and eventually to joint destruction in patients with RA.
The gradual increase of CTGF and TGF-beta1 (show TGFB1 Antibodies) expression levels in liver tissue is associated with liver fibrosis. Early expression of CTGF and TGF-beta1 (show TGFB1 Antibodies) in biliary epithelial cells may be involved in the pathogenesis of congenital biliary atresia.
Sphingosine-1-phosphate stimulates CCN2 protein production in human buccal fibroblasts. Constitutive CCN2 overexpression may enhance the profibrotic activity in oral submucous fibrosis.
small interfering RNAmediated silencing of CTGF promoted cell death and suppressed osteosarcoma cell migration and invasion.
In high-grade serous ovarian tumors the highest level of tumor stromal CTGF expression was correlated with the poorest prognosis. Identify CTGF as a promoter of peritoneal adhesion, likely to mediate metastasis, and a potential therapeutic target in high-grade serous ovarian cancer.
Findings suggest that GDF8 (show MSTN Antibodies) and CTGF may play critical roles in the regulation of proliferative events in human granulosa cells.
Studies indicate that the CYR61 (show CYR61 Antibodies) CTGF NOV (show NOV Antibodies) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Antibodies), CCN2, CCN3 (show NOV Antibodies), CCN4 (show WISP1 Antibodies), CCN5 (show WISP2 Antibodies) and CCN6 (show WISP3 Antibodies) and have been identified in various types of cancer.
renoprotective therapeutic agents can specifically abolish CCN2 expression in diabetic nephropathy; CCN2 plays a pivotal role in disease progression [review]
CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT (show ITK Antibodies)), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis.
The role of CTGF in the gastric cancer peritoneal metastasis:CTGF blocks integrin alpha3beta1-dependent adhesion of cancer cells.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Antibodies) but newly induced that of decorin (show DCN Antibodies) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
A significant increase in TGF-beta1 (show TGFB1 Antibodies) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Antibodies) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Antibodies)-, GFAP (show GFAP Antibodies)-and GFAP (show GFAP Antibodies)/Nestin (show NES Antibodies)-positive cells, activated p44 (show GTF2H2 Antibodies)/42 signaling, and upregulated fibronectin (show FN1 Antibodies). In human glioma cells, it induced GFAP (show GFAP Antibodies) and nestin (show NES Antibodies).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Antibodies) pathway, in accord with its ability to bind to the Wnt (show WNT2 Antibodies) co-receptor LDL receptor (show LDLR Antibodies)-related protein 6 (LRP6 (show LRP6 Antibodies)).
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
WNT1 inducible signaling pathway protein 2
, connective tissue growth factor
, Connective tissue growth factor
, connective tissue growth factor-like
, CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor XCTGF