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Crystallin, alpha A Proteins (CRYAA)

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping Crystallin, alpha A Antibodies (92) and Crystallin, alpha A Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human CRYAA CRYAA 1409 P02489
Rat CRYAA CRYAA 24273 P24623
Mouse CRYAA CRYAA 12954 P24622
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Top Crystallin, alpha A Proteins at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$231.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 9 to 11 Days
$479.60
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Oryzias latipes His tag   1 mg Log in to see 56 to 66 Days
$2,315.50
Details
Yeast Duck His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details
Yeast Columba livia His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details
Yeast Rana temporaria His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details
Yeast Trachemys scripta His tag   1 mg Log in to see 56 to 66 Days
$2,326.50
Details

CRYAA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Crystallin, alpha A Proteins

  1. Human CRYAA Protein expressed in Escherichia coli (E. coli) - ABIN666823 : Andley, Patel, Xi: The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for ABIN666823

More Proteins for Crystallin, alpha A (CRYAA) Interaction Partners

Xenopus laevis Crystallin, alpha A (CRYAA) interaction partners

  1. The ontogeny and localization of the alphaA-crystallin and betaB1-crystallin (show CRYBB1 Proteins) during embryonic lens development and regeneration indicated a different development program, although they have identical origins, the ectoderm.

Zebrafish Crystallin, alpha A (CRYAA) interaction partners

  1. The normal development observed in alphaA-crystallin deficient zebrafish embryos may reflect similarly non-essential roles for this protein in the early stages of both zebrafish and mammalian lens development.

  2. Fndings establish that the C-terminal extension of alphaA crystallin can be either 3D domain swapped or non-3D domain swapped.

  3. alphaA-crystallin (HSPB4) is expressed during development.

Human Crystallin, alpha A (CRYAA) interaction partners

  1. The p.R21Q mutation of CRYAA is the most likely cause of paediatric cataract in this family.

  2. these results suggest that individuals carrying the alphaA-Crystallin R12C mutation are at an increased risk to develop early-onset cataract under condition of oxidative stress

  3. alphaA-crystallin membrane insertion is oligomer-size dependent

  4. isomerization of Asp (show ASIP Proteins) might disrupt the higher order polymeric state of alpha-crystallin, resulting in decreased solubility and function, ultimately contributing to lens protein impairment and cataract formation with aging

  5. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf (show MAF Proteins).

  6. Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin (show CRYBA1 Proteins).

  7. Identification of a novel mutation in CRYAA associated with congenital cataracts.

  8. A novel disease-causing mutation, c.246_248delCGC (p.117delR), of the CRYAA gene has been identified in a Chinese family with autosomal-type perinuclear congenital cataracts.

  9. The loss of interactions between alpha A-crystallin N-terminal mutants and alpha B-crystallin (show CRYAB Proteins) signifies quaternary structural alterations due to mutation in the arginine residues.

  10. CpG islands hypermethylation of alphaA-crystallin gene may be involved in nuclear cataract formation after pars (show EPRS Proteins) plana vitrectomy.

Cow (Bovine) Crystallin, alpha A (CRYAA) interaction partners

  1. For moderate O-GlcNAcylation on bovine crystalline alpha, the preferred amino acids were Pro > Ala > Gly at position -2, Ala > Thr (show TRH Proteins) >Val > Lys (show LYZ Proteins) > Pro at position -1, and Ala > Gly > Arg > Glu (show DCTN1 Proteins) at position +2.

  2. Alpha-crystallin, in the presence of the sorbitol dehydrogenase (SDH (show SORD Proteins)) pyridine cofactor NAD(H), can exert a remarkable chaperone action by favoring the recovery of the enzyme activity from chemically denaturated SDH (show SDS Proteins) up to 77%.

  3. Conserved triad in alphaA-crystallin contributes to stability of higher order oligomers but is not essential for formation of tetramers.

  4. Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins.

Mouse (Murine) Crystallin, alpha A (CRYAA) interaction partners

  1. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf (show MAF Proteins).

  2. Knockout of alphaA-crystallin inhibited pathologic neovascularization through the VEGF (show VEGFA Proteins) and VEGFR2 (show KDR Proteins) signaling pathways both in vitro and in vivo.

  3. p53 (show TP53 Proteins) can regulate lens differentiation by controlling expression of the differentiation genes coding for the lens crystallins.

  4. Alpha A crystallin is a moonlighting protein that functions as a heat shock protein as well as a lens crystalline.

  5. alphaA-crystallin may protect against geographic atrophy.

  6. alphaA and alphaB regulate caspase-3 (show CASP3 Proteins) and Bax (show BAX Proteins) in vitro and in vivo to regulate lens differentiation.

  7. these findings show that mutation of alphaA-crystallin induces activation of the UPR during cataract formation.

  8. Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.

  9. Methionine oxidation of alpha-crystallin in combination with loss of MsrA (show MSR1 Proteins) repair causes loss of alpha-crystallin chaperone function.

  10. mouse lens epithelial cell progression through the cell cycle is significantly affected by expression of alphaA and alphaB-crystallin (show CRYAB Proteins)

Rabbit Crystallin, alpha A (CRYAA) interaction partners

Crystallin, alpha A (CRYAA) Protein Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

Gene names and symbols associated with Crystallin, alpha A Proteins (CRYAA)

  • crystallin, alpha A (cryaa)
  • crystallin, alpha A (CRYAA)
  • alphaA-crystallin (CpipJ_CPIJ005646)
  • alpha-A-crystallin protein (alpha-a-crystallin)
  • alpha-crystallin A chain-like (LOC100384978)
  • alpha-crystallin A chain-like (LOC100460863)
  • crystallin, alpha A (Cryaa)
  • Acry-1 protein
  • AI323437 protein
  • alpha-a-crystallin protein
  • Crya-1 protein
  • Crya1 protein
  • CRYAA protein
  • cryaa-A protein
  • CTRCT9 protein
  • DAcry-1 protein
  • HSPB4 protein
  • lop18 protein
  • wu:fc06h04 protein
  • zgc:92036 protein

Protein level used designations for Crystallin, alpha A Proteins (CRYAA)

crystallin, alpha A , alphaA-crystallin , [a]A-crystallin , alpha-crystallin A chain , hspb4 , alpha-A-crystallin protein , alpha-crystallin A chain-like , crystallin, alpha-1 , heat shock protein beta-4 , human alphaA-crystallin (CRYA1) , Crystallin, alpha polypeptide A , crystallin, alpha 1 , lens opacity 18 , alpha-A-crystallin , alpha A crystallin , Alpha-crystallin A chain

GENE ID SPECIES
378668 Xenopus laevis
458589 Pan troglodytes
791110 Ornithorhynchus anatinus
6037267 Culex quinquefasciatus
100000769 Danio rerio
100049490 Oryzias latipes
100384978 Callithrix jacchus
100460863 Pongo abelii
1409 Homo sapiens
24273 Rattus norvegicus
281718 Bos taurus
12954 Mus musculus
101083874 Felis catus
418546 Gallus gallus
487786 Canis lupus familiaris
100135506 Cavia porcellus
100051134 Equus caballus
100009294 Oryctolagus cuniculus
497275 Ovis aries
722370 Macaca mulatta
101520527 Ochotona princeps
101828899 Mesocricetus auratus
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