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Crystallin, alpha B Proteins (CRYAB)

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYAB Antibodies (435) and CRYAB Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRYAB 1410 P02511
CRYAB 12955 P23927
CRYAB 25420 P23928
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Top CRYAB Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$231.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Blackbird His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast Columba livia His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast Trachemys scripta His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast Lithobates catesbeiana His tag   1 mg Log in to see 56 to 66 Days
$2,401.67
Details

CRYAB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced CRYAB Proteins

  1. Human CRYAB Protein expressed in Escherichia coli (E. coli) - ABIN666824 : Hasan, Smith, Smith: Alpha-crystallin regions affected by adenosine 5'-triphosphate identified by hydrogen-deuterium exchange. in Biochemistry 2002 (PubMed)
    Show all 4 references for ABIN666824

  2. Mouse (Murine) CRYAB Protein expressed in Escherichia coli (E. coli) - ABIN666647 : Ito, Kamei, Iwamoto, Inaguma, García-Mata, Sztul, Kato: Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. in Journal of biochemistry 2002 (PubMed)
    Show all 4 references for ABIN666647

More Proteins for Crystallin, alpha B (CRYAB) Interaction Partners

Pig (Porcine) Crystallin, alpha B (CRYAB) interaction partners

  1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.

Human Crystallin, alpha B (CRYAB) interaction partners

  1. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Proteins) for SMAD4 (show SMAD4 Proteins) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

  2. alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma of the breast

  3. two novel missense mutations, p.R11C and p.R12C, in CRYAB associated with autosomal recessive congenital nuclear cataracts.

  4. Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin (show CRYBA1 Proteins).

  5. Phosphorylation of alphaB-crystallin has dual role that manifests either beneficial or deleterious consequences depending on the extent of phosphorylation and interaction with cytoskeleton. [review]

  6. The multifunctional activity of human alphaB crystallin results from the interactive peptide sequences exposed on the surface of the molecule. [review]

  7. Data show that phosphorylation of crystallin alphaB (cryAB) deters its packaging into vesicles for exosomal secretion.

  8. CRYAB protein was up regulated in laryngeal squamous cell carcinoma.

  9. was It is markedly upregulated in the substantia nigra of PD patients where Cryab was present in glial cell inclusions.

  10. A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.

Mouse (Murine) Crystallin, alpha B (CRYAB) interaction partners

  1. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter

  2. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Proteins) for SMAD4 (show SMAD4 Proteins) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

  3. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Proteins)-mediated maintenance of whole body homeostasis.

  4. A previously unrecognized link between c-Jun (show JUN Proteins) and Nrf2 (show NFE2L2 Proteins) transcription factors and redox-induced CRYAB expression in muscle cells.

  5. CryAB protects decidualization against stress conditions.

  6. TNF-alpha (show TNF Proteins)-induced endothelial adhesion molecule (show NCAM1 Proteins) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

  7. Study shows that overexpression of Bcl-2 (show BCL2 Proteins) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (show BCL2 Proteins) hearts.

  8. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (show TGFB1 Proteins) pathway via its role in modulating the cellular localization of Smad4 (show SMAD4 Proteins).

  9. Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst.

  10. Alpha B-crystallin inhibits caspase 3 activation in cells primed for apoptosis by retinoblastoma protein inactivation.

Cow (Bovine) Crystallin, alpha B (CRYAB) interaction partners

  1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

  2. In the presence of alpha-crystallin or GroEL (show GroEL Proteins) the kinetic of GAPDH (show GAPDH Proteins) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

  3. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (show NEU2 Proteins) resistance to disassembly

  4. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

CRYAB Protein Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy.

Gene names and symbols associated with Crystallin, alpha B Proteins (CRYAB)

  • crystallin, alpha B (CRYAB)
  • hypothetical protein (alpha-B-crystallin)
  • crystallin, alpha B (Cryab)
  • AACRYA protein
  • CMD1II protein
  • Crya-2 protein
  • Crya2 protein
  • CRYAB protein
  • CTPP2 protein
  • CTRCT16 protein
  • HspB5 protein
  • MFM2 protein

Protein level used designations for Crystallin, alpha B Proteins (CRYAB)

crystallin, alpha B , alpha-crystallin B chain , hypothetical protein , heat shock protein beta-5 , heat-shock 20 kD like-protein , renal carcinoma antigen NY-REN-27 , rosenthal fiber component , P23 , alpha B-crystallin , alpha(B)-crystallin , crystallin, alpha 2 , crystallin, alpha polypeptide 2 , Crystallin, alpha polypeptide 2 , Alpha(B)-crystallin , Alpha-crystallin B chain , alpha B crystallin , alpha-B-crystallin , alphaB-crystallin

GENE ID SPECIES
451543 Pan troglodytes
710747 Macaca mulatta
791109 Ornithorhynchus anatinus
100127443 Sus scrofa
191528 Caenorhabditis elegans
1410 Homo sapiens
12955 Mus musculus
281719 Bos taurus
25420 Rattus norvegicus
396089 Gallus gallus
100519789 Sus scrofa
497274 Ovis aries
100009295 Oryctolagus cuniculus
100306972 Cavia porcellus
479441 Canis lupus familiaris
101827485 Mesocricetus auratus
100172850 Pongo abelii
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