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CCNF encodes a member of the cyclin family. Additionally we are shipping Cyclin F Proteins (4) and Cyclin F Kits (1) and many more products for this protein.
Showing 10 out of 57 products:
Human Monoclonal Cyclin F Primary Antibody for WB - ABIN967556
Bai, Richman, Elledge: Human cyclin F. in The EMBO journal 1995
Show all 4 references for ABIN967556
Data indicate that a missense mutation in cyclin F (CCNF) in a large Amyotrophic lateral sclerosis (ALS (show IGFALS Antibodies)) and frontotemporal dementia (FTD (show FTL Antibodies)) family.
CDC6 (show CDC6 Antibodies) and Cyclin F interact through defined sequence motifs that promote CDC6 (show CDC6 Antibodies) ubiquitylation and degradation.
Cyclin F suppresses B-Myb (show MYBL2 Antibodies) activity to promote cell cycle checkpoint control.
Cyclin F controls genome stability through ubiquitin-mediated proteolysis. (Review)
After DNA damage, cyclin F is downregulated in an ATR (show ANTXR1 Antibodies)-dependent manner to allow accumulation of RRM2 (show RRM2 Antibodies). Defective elimination of cyclin F delays DNA repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a nondegradable RRM2 (show RRM2 Antibodies) mutant.
SCF (show KITLG Antibodies)(Cyclin F)-mediated degradation of CP110 (show CCP110 Antibodies) is required for the fidelity of mitosis and genome integrity
CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac (show ADCY10 Antibodies) and chorioallantoic placentation, die around embryonic day 10.5.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
, cyclin F
, G2/mitotic-specific cyclin-F
, G2/mitotic-specific cyclin-F-like
, g2/mitotic-specific cyclin-F-like
, F-box only protein 1