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CDK19 encodes a protein that is one of the components of the Mediator coactivator complex. Additionally we are shipping CDK19 Proteins (6) and many more products for this protein.
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Data suggest that, during neurogenesis, Mediator complex cyclin (show PCNA Antibodies)-dependent kinases (CDK8 (show CDK8 Antibodies), CDK19) interact directly with PRC2 (polycomb (show CBX2 Antibodies) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2 (show EZH2 Antibodies)), as well as SUZ12 (suppressor of zeste 12 homolog (show SUZ12 Antibodies)).
Mediator-associated kinases CDK8 (show CDK8 Antibodies) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (show RUNX1 Antibodies)) cells
Microarrays identified target genes for each CDK (show CDK4 Antibodies), and we selected six genes: two target genes of CDK8 (show CDK8 Antibodies), two target genes of CDK19 and two genes that were targets for both.
CDK8 (show CDK8 Antibodies) and CDK19, individually interact with PRMT5 (show PRMT5 Antibodies) and WDR77 (show WDR77 Antibodies), and their interactions with PRMT5 (show PRMT5 Antibodies) cause transcriptional repression of C/EBPbeta (show CEBPB Antibodies) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
cell division cycle 2-like 6 (CDK8-like)
, PITSLRE serine/threonine-protein kinase CDC2L1
, cell division cycle 2 homolog-like 1
, cell division cycle 2-like protein kinase 1
, cell division protein kinase 11
, cyclin-dependent kinase 11
, galactosyltransferase-associated protein kinase p58/GTA
, CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, death-preventing kinase
, cyclin-dependent kinase 8