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anti-Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) Antibodies

The secreted protein encoded by CYR61 is growth factor-inducible and promotes the adhesion of endothelial cells. Additionally we are shipping CYR61 Proteins (23) and CYR61 Kits (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYR61 16007 P18406
CYR61 3491 O00622
CYR61 83476 Q9ES72
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Top anti-CYR61 Antibodies at antibodies-online.com

Showing 10 out of 188 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IHC, WB Western blots analysis of Cyr expression with lysate from Jurkat cells (Lane 1) and mouse small intestine tissue(Lane 2) 100 μg Log in to see 2 to 3 Days
$336.00
Details
Human Rabbit Un-conjugated ICC, IF, SimWes, WB Detection of cleaved CYR61 in MDA-MB-231 cell lysate using ABIN151821.Photo courtesy of Dr. Lupu's Lab, Northwestern University.  Image by Dr. Ingrid Espinoza. Simple Western: Cyr61/CCN1 Antibody [ABIN251435] - Simple Western lane view shows a specific band for Cyr61 in 0.2 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. *Non-specific interaction with the 230 kDa standard may be seen with this antibody. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated BP, ICC, IF, IHC, IHC (p), Neut, SimWes, WB Detection of cleaved CYR61 in MDA-MB-231 cell lysate using ABIN151820.Photo courtesy of Dr. Lupu's Lab, Northwestern University.  Image by Dr. Ingrid Espinoza. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$242.00
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$676.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image CYR61 antibody [N1C3] detects CYR61 protein at endoplasmic reticulum by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CYR61 protein stained by CYR61 antibody [N1C3] , diluted at 1:200. Blue: Hoechst 33342 staining. IHC-P Image CYR61 antibody [N1C3] detects CYR61 protein at cytoplasm in rat intestine by immunohistochemical analysis. Sample: Paraffin-embedded rat intestine. CYR61 antibody [N1C3] , diluted at 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details

CYR61 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CYR61 Antibodies

  1. Human Polyclonal CYR61 Primary Antibody for BP, ICC - ABIN151820 : Gashaw, Stiller, Böing, Kimmig, Winterhager: Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium. in Endocrinology 2008 (PubMed)
    Show all 6 references for ABIN151820

  2. Human Polyclonal CYR61 Primary Antibody for ICC, IF - ABIN151821 : Kurozumi, Hardcastle, Thakur, Shroll, Nowicki, Otsuki, Chiocca, Kaur: Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. in Molecular therapy : the journal of the American Society of Gene Therapy 2008 (PubMed)
    Show all 4 references for ABIN151821

  3. Human Monoclonal CYR61 Primary Antibody for EIA, IHC (p) - ABIN317510 : Tong, OKelly, Xie, Mori, Lemp, McKenna, Miller, Koeffler: Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway. in Oncogene 2004 (PubMed)
    Show all 3 references for ABIN317510

  4. Human Polyclonal CYR61 Primary Antibody for IHC (fro), IHC (p) - ABIN191761 : Schütze, Kunzi-Rapp, Wagemanns, Nöth, Jatzke, Jakob: Expression, purification, and functional testing of recombinant CYR61/CCN1. in Protein expression and purification 2005 (PubMed)
    Show all 2 references for ABIN191761

  5. Human Polyclonal CYR61 Primary Antibody for IHC (fro), IHC (p) - ABIN191759 : Lienau, Schell, Epari, Schütze, Jakob, Duda, Bail: CYR61 (CCN1) protein expression during fracture healing in an ovine tibial model and its relation to the mechanical fixation stability. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2006 (PubMed)

  6. Human Polyclonal CYR61 Primary Antibody for IHC, WB - ABIN223329 : Mascareno, Galatioto, Rozenberg, Salciccioli, Kamran, Lazar, Liu, Pedrazzini, Siddiqui et al.: Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptional modulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor ? (TGF-?1) ... in The Journal of biological chemistry 2012 (PubMed)

More Antibodies against CYR61 Interaction Partners

Mouse (Murine) Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. Lysophosphatidic acid induced time-dependent phosphorylation of serum response factor and CRE-binding protein in in smooth muscle cells, inducing transcription of CCN1 (show CCNA2 Antibodies).

  2. Data show that Cysteine-rich 61 (CYR61) acts as a tumor-promoting gene in pancreatic neuroendocrine tumors.

  3. CCN1 (show CCNA2 Antibodies) is an important regulator of chondrocyte maturation during cartilage development and homeostasis.

  4. CCN1 (show CCNA2 Antibodies) exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway.

  5. Data show that RNA silencing of CCN family member 1 protein (CCN1 (show CCNA2 Antibodies)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxyge (show AKT1 Antibodies)n-induced retinopathy (OIR).

  6. These findings reveal a critical role for CCN1 (show CCNA2 Antibodies) in restoring mucosal homeostasis after intestinal injury

  7. CCN1 (show CCNA2 Antibodies) is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR (show EGFR Antibodies)-dependent hepatocyte compensatory proliferation

  8. Both knockin mice expressing a mutant CCN1 (show CCNA2 Antibodies) that is unable to bind alphavbeta3/alphavbeta5 and mice with Ccn1 (show CCNA2 Antibodies) knockdown are defective in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing.

  9. CYR61 is upregulated in acute lung injury (ALI) and CYR61 overexpression exacerbates ALI in mice.

  10. miR (show MLXIP Antibodies)-155 functions in tandem with CCN1 (show CCNA2 Antibodies) to modulate inflammation-induced vascular homeostasis and repair.

Human Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. CCN1 (show CCNA2 Antibodies) RNAi reduced the mRNA and protein expression levels of CCN1 (show CCNA2 Antibodies), Akt (show AKT1 Antibodies) and VEGF (show VEGFA Antibodies) in the HUVECs (P<0.05). Furthermore, LY294002 reduced the mRNA and protein expression levels of CCN1 (show CCNA2 Antibodies) in the hypoxic cells (P<0.05). Therefore, CCN1 (show CCNA2 Antibodies) RNAi may offer a novel therapeutic strategy, which may aid in the treatment of pathological angiogenesis via inhibition of the PI3K (show PIK3CA Antibodies)/AktVEGF pathway

  2. High CYR61 expression is associated with colorectal cancer.

  3. Following the treatment of B16 cells with epirubicin and IFN-a (show IFNA6 Antibodies), CYR61 levels increased, cell growth was inhibited, and proliferating cell nuclear antigen (show PCNA Antibodies) expression decreased. Thus, CYR61 could become a therapeutic target for malignant melanoma patients with high CYR61 expression.

  4. The present study aimed to examine the clinical relevance of NOV (show NOV Antibodies) along with CYR61 and CTGF (show CTGF Antibodies) in gastric cancer by analysing their transcript levels...the expression of NOV (show NOV Antibodies) and CYR61 was increased in gastric cancer. The elevated expression of CYR61 was associated with poorer survival. NOV (show NOV Antibodies) promoted proliferation and invasion of gastric cancer cells

  5. Taken together, our results provide novel insights into the possible protective role of 7,8-DHF by activating Cyr61 signaling and suppressing ER stress in hypoxic HK-2 (show HK2 Antibodies) cells which have potential clinical implications for the treatment of AKI.

  6. Data show that RNA silencing of CCN family member 1 protein (CCN1 (show CCNA2 Antibodies)) inhibits umbilical vein endothelial cell (HUVEC) proliferation under hypoxic conditions by inhibiting phosphoinositide 3-kinase (PI3K (show PIK3CA Antibodies))/AKT (show AKT1 Antibodies) protein signaling.

  7. Studies indicate that the CYR61 CTGF (show CTGF Antibodies) NOV (show NOV Antibodies) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Antibodies), CCN2 (show CTGF Antibodies), CCN3 (show NOV Antibodies), CCN4 (show WISP1 Antibodies), CCN5 (show WISP2 Antibodies) and CCN6 (show WISP3 Antibodies) and have been identified in various types of cancer.

  8. Results suggest that Cyr61 is induced by EGF (show EGF Antibodies) through the ERK (show EPHB2 Antibodies)/CREB (show CREB1 Antibodies) signal pathway and that it plays a crucial role in the migration and invasion of anaplastic thyroid cancer cells.

  9. CCN1 (show CCNA2 Antibodies) is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR (show EGFR Antibodies)-dependent hepatocyte compensatory proliferation

  10. we demonstrate that NF2 (show NF2 Antibodies) negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Antibodies)-dependent induction of CYR61/CCN1 and miR (show MLXIP Antibodies)-296-3p.

Cow (Bovine) Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. The increased expression of CYR61 in the Day 4 corpus lutum (CL) and its transient increase by prostaglandin F2alpha in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL.

  2. Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.

  3. Mechanical regulation of the Cyr61 gene in smooth muscle cells

CYR61 Antigen Profile

Protein Summary

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.

Gene names and symbols associated with CYR61

  • cysteine-rich, angiogenic inducer, 61 (cyr61) antibody
  • cysteine-rich, angiogenic inducer, 61 (CYR61) antibody
  • small ubiquitin-like modifier 3 (sumo3) antibody
  • cysteine-rich, angiogenic inducer, 61 (LOC100230216) antibody
  • cysteine rich protein 61 (Cyr61) antibody
  • cysteine-rich, angiogenic inducer, 61 (Cyr61) antibody
  • AI325051 antibody
  • CCN1 antibody
  • CYR61 antibody
  • cyr61-l2 antibody
  • GIG1 antibody
  • IGFBP10 antibody
  • MGC69281 antibody
  • MGC69539 antibody
  • smt3a antibody
  • smt3h1 antibody
  • sumo-3 antibody
  • Xcyr61 antibody
  • zgc:158158 antibody

Protein level used designations for CYR61

cysteine-rich, angiogenic inducer, 61 , SMT3 suppressor of mif two 3 homolog 3 , small ubiquitin-related modifier 3 , protein CYR61-like , 3CH61 , CCN family member 1 , IBP-10 , IGF-binding protein 10 , IGFBP-10 , cysteine-rich angiogenic inducer 61 , insulin-like growth factor binding protein 10 , insulin-like growth factor-binding protein 10 , intermediate early , protein CYR61 , cysteine-rich heparin-binding protein 61 , cysteine-rich, anigogenic inducer, 61 , cysteine rich protein 61 , secreted cysteine-rich protein cyr61

GENE ID SPECIES
448140 Xenopus (Silurana) tropicalis
553273 Danio rerio
714970 Macaca mulatta
100125978 Xenopus (Silurana) tropicalis
100230216 Taeniopygia guttata
100413443 Callithrix jacchus
100445022 Pongo abelii
100471762 Ailuropoda melanoleuca
16007 Mus musculus
3491 Homo sapiens
83476 Rattus norvegicus
429089 Gallus gallus
379598 Xenopus laevis
479967 Canis lupus familiaris
508941 Bos taurus
456988 Pan troglodytes
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