anti-Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Antibodies

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Additionally we are shipping CFTR Kits (33) and CFTR Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CFTR 12638 P26361
CFTR 24255 P34158
CFTR 1080 P13569
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Top anti-CFTR Antibodies at antibodies-online.com

Showing 10 out of 234 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) Formalin fixed paraffin embedded human pancreas stained with CFTR antibody ABIN115197 1 mL Log in to see 6 to 8 Days
$841.50
Details
Chicken Mouse Un-conjugated BP, FACS, ICC, IF, IHC, IHC (p), IP, Neut, WB Immunocytochemistry/Immunofluorescence: CFTR Antibody (CF3) [ABIN152670] - CFTR staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing CFTR at a dilution of 1:100-1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry-Paraffin: CFTR Antibody (CF3) [ABIN152670] - Cancer biopsies of deparaffinized Human colon carcinoma tissue. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IF, IHC (p) 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF Figure 1 shows immunolocalization of CFTR in HEK293 cells stably transfected with the CFTR gene. 0.1 mg Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IF, IP, WB   0.1 mg Log in to see 11 to 13 Days
$600.60
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CFTR antibody, Western blotting WB: Rat Pancreas Tissue Lysate Anti-CFTR antibody, IHC(P) IHC(P): Human Pancreatic Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Goat Un-conjugated IHC (p) AP23980PU-N ABCC7/CFTR antibody staining of Formalin-Fixed, Paraffin-Embedded Human Kidney. AP23980PU-N ABCC7/CFTR antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using CFTR Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using CFTR (Ab-737) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$346.50
Details

CFTR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CFTR Antibodies

  1. Chicken Monoclonal CFTR Primary Antibody for BP, FACS - ABIN152670 : Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995 (PubMed)
    Show all 9 references for 152670

  2. Human Monoclonal CFTR Primary Antibody for IHC (p) - ABIN115197 : Sealock, Butler, Kramarcy, Gao, Murnane, Douville, Froehner: Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle. in The Journal of cell biology 1991 (PubMed)

  3. Human Monoclonal CFTR Primary Antibody for IF, IP - ABIN180604 : Kartner, Augustinas, Jensen, Naismith, Riordan: Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland. in Nature genetics 1993 (PubMed)

More Antibodies against CFTR Interaction Partners

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. NDPK-A (show NME1 Antibodies) exists in a functional cellular complex with AMPK (show PRKAA2 Antibodies) and CFTR in airway epithelia, and NDPK-A (show NME1 Antibodies) catalytic function is required for the AMPK (show PRKAA2 Antibodies)-dependent regulation of CFTR

  2. Study conclude that when both CFTR and NPT2a (show SLC34A1 Antibodies) are expressed in X. laevis oocytes, CFTR confers to NPT2a (show SLC34A1 Antibodies) a cAMPi-dependent trafficking to the membrane.

  3. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase (show DNAH8 Antibodies) cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  4. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (show ABCB6 Antibodies)) transporters.

  5. These data suggest that the Xenopus P2Y1 receptor (show P2RY1 Antibodies) can increase both cyclic AMP (show TMPRSS5 Antibodies)/protein kinase A and calcium/protein kinase C (show PKC Antibodies) levels and that the PKC (show PKC Antibodies) pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  2. Insulin (show INS Antibodies) stimulation of Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) signaling in Cystic fibrosis (show S100A8 Antibodies) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  3. Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Antibodies) dramatically reduces the expression level of total and cell surface Mrp2 (show ABCC2 Antibodies) in Huh-7 cells. Our findings suggest that CAL (show S100A11 Antibodies) interacts with Mrp2 (show ABCC2 Antibodies) and is a negative regulator of Mrp2 (show ABCC2 Antibodies) expression.

  4. Myelinosomes secreted from testis somatic TM4 (show TPM4 Antibodies) Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt (show HTT Antibodies)) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (show S100A8 Antibodies) (CF), F508delCFTR.

  5. ATP8B1 (show ATP8B1 Antibodies) is important for proper CFTR expression and function.

  6. Loss of cystic fibrosis (show S100A8 Antibodies) transmembrane regulator impairs intestinal oxalate secretion

  7. CFTR plays a role in suppressing MAPK (show MAPK1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) to relieve inflammation, reduce proliferation and promote differentiation of keratinocytes, and thus promotes cutaneous wound healing.

  8. physiological fetal hypercalcemia, acting on the CaSR (show CASR Antibodies), promotes human fetal lung development via cAMP-dependent opening of CFTR.

  9. CFTR expressed by alveolar or peritoneal macrophages regulates acute proinflammatory responses.

  10. CFTR silencing in pancreatic beta-cells significantly reduced insulin (show INS Antibodies) output in response to glucose, and made the cells more sensitive to oxidative stress.

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Data suggest that the stability of the second nucleotide-binding domain (NBD2) of CFTR (which exhibits a catalytically active ATPase (show DNAH8 Antibodies) active site and ATP binding site) can be affected by specific point mutations or deletion mutations; point mutations and deletion mutations observed in patients with cystic fibrosis (show S100A8 Antibodies) were used in this study.

  2. Structural changes fundamental to gating of the cystic fibrosis transmembrane conductance regulator anion channel pore have been summerized. (Review)

  3. Resting neutrophils had pronounced CFTR expression. Neutrophil ativation with soluble or particulate agonists did not significantly increase CFTR expression, but induced its redistribution to cell surface. CFTR mobilization correlated with cell-surface recruitment of formyl-peptide receptor during secretory vesicle exocytosis. Neutrophils with DeltaF508-CF showed little cell-surface mobilization upon stimulation.

  4. Considerable progress has been made over the last years in the understanding of the molecular basis of the CFTR functions, as well as dysfunctions causing the common genetic disease cystic fibrosis (show S100A8 Antibodies) (CF). This review provides a global overview of the theoretical studies that have been performed so far, especially molecular modelling and molecular dynamics (MD) simulations. [review]

  5. CFTR gating is regulated in complex manner as phosphorylation is mandatory for channel activity and gating is directly regulated by binding of ATP to specific intracellular sites on the CFTR protein. This review covers our current understanding on the gating mechanism in CFTR and illustrates the relevance of alteration of these mechanisms in the onset of cystic fibrosis (show S100A8 Antibodies). [review]

  6. This review will discuss the effects of PKA phosphorylation on wild-type CFTR, the consequences of cystic fibrosis (show S100A8 Antibodies) mutations on PKA phosphorylation, and the development of therapies that target PKA-mediated signaling. [review]

  7. As an ion channel, CFTR must form a continuous pathway across the cell membrane-referred to as the channel pore-for the rapid electrodiffusional movement of ions. This review summarizes our current understanding of the architecture of the channel pore, as defined by electrophysiological analysis and molecular modeling studies. [review]

  8. This review covers old and recent knowledge on CFTR folding and trafficking from its synthesis to the regulation of its stability at the plasma membrane and highlights how several of these steps can be modulated to promote the rescue of mutant CFTR. [review]

  9. This review explores the link between stability and structure/function relationships of membrane proteins and CFTR in particular and how approaches to study CFTR structure depend on its stability. [review]

  10. CFTR regulates many mechanisms in epithelial physiology, such as maintaining epithelial surface hydration and regulating luminal pH. This chapter illustrates the different operational roles of CFTR in epithelial function by describing its characteristics in three different tissues: the airways, the pancreas, and the sweat gland. [review]

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (show TGFB1 Antibodies), via TGF-beta1 (show TGFB1 Antibodies) receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (show SNRPG Antibodies)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (show S100A8 Antibodies) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (show S100A8 Antibodies) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (show AVP Antibodies) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (show DNASE1 Antibodies) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (show SLC26A6 Antibodies)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

CFTR Antigen Profile

Protein Summary

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Gene names and symbols associated with CFTR

  • cystic fibrosis transmembrane conductance regulator (cftr-A) antibody
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR) antibody
  • cystic fibrosis transmembrane conductance regulator (Cftr) antibody
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (Cftr) antibody
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr) antibody
  • cystic fibrosis transmembrane conductance regulator homolog (Cftr) antibody
  • abc35 antibody
  • abcc7 antibody
  • AW495489 antibody
  • CF antibody
  • CFTR antibody
  • cftr/mrp antibody
  • dJ760C5.1 antibody
  • mrp7 antibody
  • RGD1561193 antibody
  • tnr-cftr antibody
  • xcftr antibody

Protein level used designations for CFTR

cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase

GENE ID SPECIES
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
1080 Homo sapiens
100049619 Gallus gallus
492302 Canis lupus familiaris
403154 Sus scrofa
281067 Bos taurus
100009471 Oryctolagus cuniculus
100719898 Cavia porcellus
100071259 Equus caballus
443347 Ovis aries
100381094 Xenopus laevis
100137035 Pongo abelii
463674 Pan troglodytes
100126675 Papio anubis
100135647 Cavia porcellus
Selected quality suppliers for anti-CFTR (CFTR) Antibodies
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