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Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Additionally we are shipping Cytosolic Thiouridylase Subunit 1 Homolog (S. Pombe) Proteins (15) and many more products for this protein.
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Human Polyclonal CTU1 Primary Antibody for EIA, IHC (p) - ABIN950575
Schlieker, Van der Veen, Damon, Spooner, Ploegh: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
cytoplasmic tRNA 2-thiolation protein 1
, ATP binding domain 3
, ATP-binding domain-containing protein 3
, cancer-associated gene protein
, cancer-associated protein
, cytoplasmic tRNA adenylyltransferase 1
, cytosolic thiouridylase subunit 1 homolog