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This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Additionally we are shipping DNMT3A Antibodies (10) and many more products for this protein.
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These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.
Loss of DNMT3A expression is associated with development of malignancy.
confirm the transformation potential of DNMT3A(R882H) Tet2 (show TET2 ELISA Kits)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (show TET2 ELISA Kits) inactivation driving lymphoid malignancies
overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (show TFAP2A ELISA Kits) knockdown.
These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.
in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.
Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (show FLT3 ELISA Kits) gene (Flt3 (show FLT3 ELISA Kits)(ITD)) and the nucleophosmin (show NPM1 ELISA Kits) gene (Npm1 (show GJA1 ELISA Kits)(c)) to induce AML (show RUNX1 ELISA Kits) in vivo, and promoted resistance to anthracycline chemotherapy.
miR (show MLXIP ELISA Kits)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR (show UTS2R ELISA Kits)). Our data reveal a novel mechanism of miR (show MLXIP ELISA Kits)-29a/b/c in the regulation of adipogenesis
DOT1L (show DOT1L ELISA Kits) may play a critical role in DNMT3A-mutant leukemia.
Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (show HELLS ELISA Kits) during postnatal neurological development.
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
DNA (cytosine-5)-methyltransferase 3A
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA
, DNA methyltransferase 3A