DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (DOT1L)

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies (77) and DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
Rat DOT1L DOT1L 362831  
Mouse DOT1L DOT1L 208266  
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Top DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 25 μg Log in to see 2 to 3 Days
$225.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag DOT1L (1-416), active activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of DOT1L (1-416), active. Activity was detected by fluorography. Recombinant DOT1L (1-416), active protein gel. Recombinant DOT1L (1-416), active run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$466.67
Details
Yeast Aspergillus oryzae His tag   1 mg Log in to see 60 to 71 Days
$2,905.83
Details

DOT1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. our results identify DOT1L as a novel cofactor in N-Myc (show MYCN Proteins)-mediated transcriptional activation of target genes and neuroblastoma (show ARHGEF16 Proteins) oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN (show MYCN Proteins)-amplified neuroblastoma (show ARHGEF16 Proteins).

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Proteins) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL Proteins) fusion-AF4 complex and DOT1L for more effective treatment of MLL (show MLL Proteins)-rearranged leukemia.

  3. this indicates that DOT1L function, like MLL (show MLL Proteins), does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL (show MLL Proteins) fusion-induced leukemia cells of murine and human origin

  4. DOT1L may play a critical role in DNMT3A (show DNMT3A Proteins)-mutant leukemia.

  5. DOT1L, via dimethylated histone H3 (show HIST3H3 Proteins) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (show BRD4 Proteins) to chromatin in acute lymphoblastic leukemia.

  6. study demonstrates the development of potent DOT1L inhibitors with novel scaffolds

  7. these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 (show LILRB2 Proteins) production leading to up-regulation of RhoGTPase and survival proteins.

  8. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  9. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  10. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Proteins) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL Proteins) fusion-AF4 complex and DOT1L for more effective treatment of MLL (show MLL Proteins)-rearranged leukemia.

  3. DOT1L may play a critical role in DNMT3A (show DNMT3A Proteins)-mutant leukemia.

  4. DOT1L, via dimethylated histone H3 (show HIST3H3 Proteins) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (show BRD4 Proteins) to chromatin in acute lymphoblastic leukemia.

  5. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 (show ATP6V1B1 Proteins) is a new transcriptional target of Dot1l.

  6. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  7. Interference with DOT1L activity resulted in transcriptional activation of Atf4 (show ATF4 Proteins) and Ddit3 (show DDIT3 Proteins) accompanied by decreased levels of H3K79 dimethylation.

  8. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  9. DOT1L has a role in inhibiting SIRT1 (show SIRT1 Proteins)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (show MLL Proteins)-rearranged leukemia

  10. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Protein Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (Dot1l)
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L)
  • C terminus is similar to that of S. cerevisiae DOT1 (YDR440W) nucleosomal histone H3-Lys79 methylase involved in meiosis and transcriptional silencing (DOT1)
  • DOT1-like histone H3K79 methyltransferase (DOT1L)
  • DOT1-like histone H3K79 methyltransferase (Dot1l)
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l)
  • A630076O07 protein
  • AW907654 protein
  • Dot1 protein
  • DOT1L protein
  • KMT4 protein
  • mDot1 protein
  • NV11307 protein

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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