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Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. Additionally we are shipping DGKE Antibodies (55) and DGKE Kits (1) and many more products for this protein.
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Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin (show HTT Proteins) toxicity.
A regulatory role is suggested for DGK epsilon, COX-2, and catecholamine signaling during kindling epileptogenesis.
Letter/Case Report: atypical haemolytic uraemic syndrome in a Japanese patient with DGKE genetic mutations.
Report DGKE intronic mutations located beyond the exon-intron boundaries in familial hemolytic uremic syndrome.
Data suggest that complement dysregulation influences the onset and disease severity in carriers of diacylglycerol kinase-epsilon mutations
DGKE silencing in resting endothelial cells does not affect complement activation at their surface.
Our study expands the clinical phenotypes associated with mutations in DGKE and challenges the benefits of complement blockade treatment in such patients
DGKzeta (show DGKZ Proteins) localizes to the nucleus and is considered to regulate nuclear diacylglycerol signaling.[review]
Fully activating high-density transfected muscarinic receptors (M1Rs) by oxotremorine-M (Oxo-M) leads to similar calcium, DAG, and PKC signals, but PIP2 is depleted.
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome.
Substrate specificity of DGKE is not a consequence of competition with hydrolysis of ATP.
performed homozygosity mapping and whole exome sequencing in a Turkish consanguineous family and identified DGKE gene variants as the cause of a membranoproliferative-like glomerular microangiopathy
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis.
diacylglycerol kinase, epsilon 64kDa
, diacylglycerol kinase epsilon
, diacylglycerol kinase epsilon-like
, diacylglycerol kinase, epsilon
, DAG kinase epsilon
, diglyceride kinase epsilon