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Dihydrolipoamide Dehydrogenase Proteins (DLD)

DLD encodes the L protein of the mitochondrial glycine cleavage system. Additionally we are shipping DLD Antibodies (106) and DLD Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLD 1738 P09622
DLD 13382 O08749
Rat DLD DLD 298942 Q6P6R2
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Top DLD Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$3,294.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details

DLD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced DLD Proteins

  1. Human DLD Protein expressed in Escherichia coli (E. coli) - ABIN666962 : Daee, Mertz, Shcherbakova: A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for ABIN666962

More Proteins for Dihydrolipoamide Dehydrogenase (DLD) Interaction Partners

Arabidopsis thaliana Dihydrolipoamide Dehydrogenase (DLD) interaction partners

  1. These findings show that the plastidial LIPOAMIDE DEHYDROGENASE, ptLPD, isoforms are critical in vivo determinants of arsenite-mediated arsenic sensitivity in Arabidopsis and possible strategic targets for increasing arsenic tolerance. [ptLPD2]

Pig (Porcine) Dihydrolipoamide Dehydrogenase (DLD) interaction partners

  1. Human, mouse, and pig Dld has moonlighting function as a protease in addition to its canonical function as a a dehydrogenase.

  2. Lipoamide dehydrogenase significantly accelerates the conversion of a defined subset of NO donors to NO.

Human Dihydrolipoamide Dehydrogenase (DLD) interaction partners

  1. Mitochondrial dihydrolipoamide dehydrogenase is upregulated in response to the brain intermittent hypoxic preconditioning.

  2. IgA autoantibody against DLD could be a novel diagnostic marker for endometrial cancer.

  3. Case Report: novel mutation in the DLD interface giving rise to DLD deficiency.

  4. Certain DLD mutations can simultaneously induce the loss of a primary metabolic activity and the gain of a moonlighting proteolytic activity thus contributing to the metabolic derangement associated with DLD deficiency.

  5. This molecular dynamics study proposes the structural changes that may lead to the modulation in reactive oxygen species generation by pathogenic mutants of human dihydrolipoamide dehydrogenase.

  6. the cryptic activities of DLD promote oxidative damage to neighboring molecules and thus contribute to the clinical severity of DLD mutations

  7. Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex.

  8. the E3 binding protein (show PDHX Proteins) component of the pyruvate dehydrogenase (show PDP Proteins) complex appear to be a rare cause of pyruvate dehydrogenase (show PDP Proteins) deficiency

  9. Activity of human dihydrolipoamide dehydrogenase is reduced by mutation at threonine-44 of FAD (show BRCA2 Proteins)-binding region to valine.

  10. model of the pyruvate dehydrogenase (show PDP Proteins) complex formed by E2 and E2 plus the E3-binding protein (show PDHX Proteins) and binding of the E1 and E3 components

Mouse (Murine) Dihydrolipoamide Dehydrogenase (DLD) interaction partners

  1. Mitochondrial dihydrolipoamide dehydrogenase is upregulated in response to the brain intermittent hypoxic preconditioning.

  2. DLD, malic acid, and fumaric acid can be used for development of cosmeceuticals and nutraceuticals regulating the change of skin metabolism induced by the UVB overexposure.

  3. Data show that mitochondrial diaphorases (dihydrolipoamide dehydrogenase) in the liver contribute up to 81% to the NAD(+) pool during respiratory inhibition.

  4. Human, mouse, and pig Dld has moonlighting function as a protease in addition to its canonical function as a a dehydrogenase.

  5. identification and characterization of human and mouse D-lactate dehydrogenase (NAD) [D-LDH]

  6. Mice that are deficient in dihydrolipoamide dehydrogenase show increased vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 Proteins)), malonate and 3-nitropropionic acid, which have been used in models of Parkinson disease and Huntington disease (show HTT Proteins)

DLD Protein Profile

Protein Summary

This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.

Gene names and symbols associated with DLD

  • dihydrolipoamide dehydrogenase (DLD)
  • dihydrolipoyl dehydrogenase (AT4G16155)
  • dihydrolipoyl dehydrogenase (CND05840)
  • dihydrolipoyl dehydrogenase (bfmBC)
  • dihydrolipoyl dehydrogenase (GCSL)
  • dihydrolipoyl dehydrogenase (LACBIDRAFT_182385)
  • dihydrolipoyl dehydrogenase (UREG_06178)
  • dihydrolipoamide dehydrogenase (lpd)
  • dihydrolipoamide dehydrogenase (Tagg_0410)
  • dihydrolipoamide dehydrogenase (Arnit_2606)
  • dihydrolipoamide dehydrogenase (Mesil_1945)
  • dihydrolipoamide dehydrogenase (Trad_2118)
  • dihydrolipoamide dehydrogenase (Deba_2198)
  • dihydrolipoamide dehydrogenase (Deba_2981)
  • dihydrolipoamide dehydrogenase (Toce_0808)
  • dihydrolipoamide dehydrogenase (Toce_1429)
  • dihydrolipoamide dehydrogenase (Toce_2027)
  • dihydrolipoamide dehydrogenase (Acear_0640)
  • dihydrolipoamide dehydrogenase (Fbal_0372)
  • dihydrolipoamide dehydrogenase (Ilyop_1890)
  • dihydrolipoamide dehydrogenase (Lbys_2718)
  • dihydrolipoamide dehydrogenase (Lbys_3490)
  • dihydrolipoamide dehydrogenase (Ftrac_1733)
  • dihydrolipoamide dehydrogenase (Ocepr_1753)
  • dihydrolipoamide dehydrogenase (Intca_2017)
  • dihydrolipoamide dehydrogenase (Deima_0504)
  • dihydrolipoamide dehydrogenase (dldh)
  • dihydrolipoamide dehydrogenase (Dld)
  • lactate dehydrogenase D (Ldhd)
  • 4733401P21Rik protein
  • AI315664 protein
  • AI746344 protein
  • D8Bwg1320e protein
  • DDBDRAFT_0183800 protein
  • DDBDRAFT_0216232 protein
  • DDB_0183800 protein
  • DDB_0216232 protein
  • DLD protein
  • DLDD protein
  • DLDH protein
  • E3 protein
  • GCSL protein
  • LAD protein
  • PHE3 protein
  • wu:fb24b05 protein

Protein level used designations for DLD

dihydrolipoamide dehydrogenase , dihydrolipoyl dehydrogenase , protein BfmBC , dihydrolipoamide:NAD oxidoreductase , glycine cleavage system L-protein , dihydrolipoyl dehydrogenase, mitochondrial , lipoamide dehydrogenase , E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex , diaphorase , glycine cleavage system L protein , glycine cleavage system protein L , lipoamide reductase , lipoyl dehydrogenase , fb24b05 , branched chain alpha-keto acid dehydrogenase complex subunit E3 , dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) , dihydrolipoamide: NAD+ oxidoreductase , Dihydrolipoyl dehydrogenase, mitochondrial , DLD , probable D-lactate dehydrogenase, mitochondrial

GENE ID SPECIES
463861 Pan troglodytes
827307 Arabidopsis thaliana
3257043 Cryptococcus neoformans var. neoformans JEC21
5390805 Clostridium kluyveri DSM 555
5720812 Chlamydomonas reinhardtii
6070887 Laccaria bicolor S238N-H82
8441855 Uncinocarpus reesii 1704
8628069 Dictyostelium discoideum AX4
9165424 Thermosphaera aggregans DSM 11486
9172784 Arcobacter nitrofigilis DSM 7299
9251457 Meiothermus silvanus DSM 9946
9281114 Truepera radiovictrix DSM 17093
9494668 Desulfarculus baarsii DSM 2075
9495467 Desulfarculus baarsii DSM 2075
9510444 Thermosediminibacter oceani DSM 16646
9511087 Thermosediminibacter oceani DSM 16646
9511700 Thermosediminibacter oceani DSM 16646
9512662 Acetohalobium arabaticum DSM 5501
9769107 Ferrimonas balearica DSM 9799
9869436 Ilyobacter polytropus DSM 2926
9956591 Leadbetterella byssophila DSM 17132
9957376 Leadbetterella byssophila DSM 17132
10011879 Marivirga tractuosa DSM 4126
10016623 Oceanithermus profundus DSM 14977
1794899 Rhodopirellula baltica SH 1
10084837 Intrasporangium calvum DSM 43043
10149823 Deinococcus maricopensis DSM 21211
397129 Sus scrofa
1738 Homo sapiens
399479 Danio rerio
13382 Mus musculus
298942 Rattus norvegicus
403978 Canis lupus familiaris
100174022 Pongo abelii
100689437 Cricetulus griseus
101831240 Mesocricetus auratus
52815 Mus musculus
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