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Dishevelled Segment Polarity Protein 1 Proteins (DVL1)

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. Additionally we are shipping DVL1 Antibodies (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DVL1 1855 O14640
DVL1    
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Top DVL1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details

DVL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Dishevelled Segment Polarity Protein 1 (DVL1) Interaction Partners

Human Dishevelled Segment Polarity Protein 1 (DVL1) interaction partners

  1. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.

  2. Specific -1 frameshift variants in the penultimate exon of DVL1 cause autosomal-dominant Robinow syndrome.

  3. Results show that coexpression of IQGAP1 and Dvl (show DVL2 Proteins) in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of non-small cell lung cancer.

  4. Data indicate Dishevelled (DVL (show DVL2 Proteins)) as a dual function adaptor to recruit negative regulators ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) to Wnt (show WNT2 Proteins) receptors to ensure proper control of pathway activity.

  5. silencing DVL1 sensitized A2780/Taxol cells to paclitaxel, by down-regulating AKT (show AKT1 Proteins)/GSK-3beta/beta-catenin (show CTNNB1 Proteins) signalling, providing a novel strategy for chemosensitization of ovarian cancer to paclitaxel-induced cytotoxicity.

  6. Mutations in DVL1 cause an osteosclerotic (show TCIRG1 Proteins) form of Robinow syndrome, with the osteosclerosis possibly the result of an interaction between the wild-type and mutant alleles, leading to elevated canonical Wnt (show WNT2 Proteins) signaling.

  7. DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.

  8. Authors propose a model for Rac1 activation where SIRT1/2 positively modulates the DVL/TIAM1/Rac1 axis and promotes sustained pathway activation.

  9. Dvl (show DVL2 Proteins) overexpression may contribute to the malignant proliferation and invasion of human glioma.

  10. DVL is a master regulator of FZD6/G-protein signaling

DVL1 Protein Profile

Protein Summary

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Gene names and symbols associated with DVL1

  • dishevelled segment polarity protein 1 (DVL1)
  • DVL protein
  • DVL1L1 protein
  • DVL1P1 protein

Protein level used designations for DVL1

DSH homolog 1 , dishevelled 1 (homologous to Drosophila dsh) , dishevelled, dsh homolog 1 , dishevelled-1 , segment polarity protein dishevelled homolog DVL-1

GENE ID SPECIES
1855 Homo sapiens
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