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Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) Proteins (DDC)

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Additionally we are shipping DDC Antibodies (141) and DDC Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DDC 13195 O88533
DDC 1644 P20711
DDC 24311 P14173
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Top DDC Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$602.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,356.83
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$3,356.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,375.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details

DDC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , ,
,
Rat (Rattus)

Top referenced DDC Proteins

  1. Human DDC Protein expressed in Baculovirus infected Insect Cells - ABIN3216385 : Scherer, McPherson, Wasmuth, Marsh: Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs. in Genomics 1992 (PubMed)
    Show all 4 references for ABIN3216385

  2. Mouse (Murine) DDC Protein expressed in Baculovirus infected Insect Cells - ABIN2008312 : Ichinose, Kurosawa, Titani, Fujita, Nagatsu: Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase. in Biochemical and biophysical research communications 1989 (PubMed)
    Show all 4 references for ABIN2008312

  3. Human DDC Protein expressed in Escherichia coli (E. coli) - ABIN667092 : Avgeris, Koutalellis, Fragoulis, Scorilas: Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer. in Clinical biochemistry 2008 (PubMed)
    Show all 2 references for ABIN667092

More Proteins for Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) Interaction Partners

Fruit Fly (Drosophila melanogaster) Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements

  2. Broad-Complex protein is required for Ddc activation at eclosion in Drosophila

  3. evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh (show GNRH1 Proteins) protein binding site and the function of the grh (show GNRH1 Proteins) gene

  4. The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces.

  5. The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.

Rhesus Monkey Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. Combinatorial expression of tyrosine hydroxylase (TH (show TH Proteins)), aromatic acid acid decarboxylase (AADC), and the brain-specific (show CALY Proteins) isoform of the vesicular monoamine transporter (show Slc18a2 Proteins), VMAT2 (show Slc18a2 Proteins).

Zebrafish Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. Loss of Ddc appears to result in similar phenotypes as that of ADCC deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of AADC deficiency in children.

Mouse (Murine) Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.

  2. Mash1 (show ASCL1 Proteins) plays an important role in regulating the expression of AADC in type III cells in taste buds.

  3. evidence for PKGIalpha-dependent phosphorylation and activation of neuronal AAAD (show AADAC Proteins) in vitro, and introduce AAAD (show AADAC Proteins) as a putative PKGIalpha substrate.

  4. Data suggest a possible participation of aromatic L-amino acid decarboxylase (AADC) in the regulation of catecholamine biosynthesis in stellate ganglia of repeatedly stressed mice.

  5. Results suggest that AADC expression begins at early stages of taste bud cell differentiation, and biogenic amines may act on taste bud differentiation of tongue epithelial cells, and further may regulate innervation of taste bud progenitor cells.

  6. analysis of Ddc redefines the imprinted Grb10 (show GRB10 Proteins) domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene

  7. the fact that renal DDC inversely correlated with renal sodium reabsorption suggest that renal and intestinal gender dimorphism in DDC could be related to sex-related differences in sodium balance observed between males and females

Human Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. The data showed that L-DOPA decarboxylase constitutes a highly promising molecular marker for renal cell carcinoma (show MOK Proteins).

  2. gene study of 987 BPD cases and 1110 healthy controls found an association between BPD [ borderline personality disorder ]and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene

  3. Results revealed the general picture of structural and/or functional effects of each DDC mutation linked to AADC deficiency mutations and help to guide therapeutic decision and prevent inappropriate use of treatment regiments.

  4. A novel homozygous DDC variant in syndromic intellectual disability patients, c.1123C>T, resulting in p.Arg375Cys missense substitution.

  5. Results indicate that miR (show MLXIP Proteins)-145 has the ability to regulate DDC mRNA expression and potentially this occurs by recognizing its mRNA as a target.

  6. Our results suggest that DDC may be a genetic modifier of the l-dopa response in Parkinson's disease

  7. assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (show DRD2 Proteins) (rs1800496, rs1801028, and rs1799732), DRD4 (show DRD4 Proteins) (rs4646984 and rs4646983), and COMT (show COMT Proteins) (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes

  8. 8 SNPs in DDC gene showed significant associations with MaxDrinks.

  9. Common allelic variants in the DDC gene may be involved in autism susceptibility.

  10. The data of this study confirm histidine decarboxylase (show HDC Proteins) deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology.

Pig (Porcine) Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) interaction partners

  1. The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5'-phosphate (PLP (show PLP1 Proteins)) enzyme DOPA decarboxylase (DDC) was here investigated.

DDC Protein Profile

Protein Summary

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with DDC

  • Dopa decarboxylase (Ddc)
  • alpha methyl dopa-resistant (amd)
  • dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC)
  • dopa decarboxylase (aromatic L-amino acid decarboxylase) (ddc)
  • dopa decarboxylase (Ddc)
  • Dopa-decarboxylase (Dvir\\Ddc)
  • dopa decarboxylase (ddc)
  • dopa decarboxylase (aromatic L-amino acid decarboxylase) (Ddc)
  • 5-HT protein
  • Aadc protein
  • AMD-r protein
  • CG10501 protein
  • CG10697 protein
  • CG17345 protein
  • Ddc protein
  • DdcDm protein
  • DdcDv protein
  • Dmel\\CG10501 protein
  • Dmel\\CG10697 protein
  • Dvir\\GJ17995 protein
  • dvir_GLEANR_2561 protein
  • fAMD protein
  • fDDC protein
  • GJ17995 protein
  • l(2)37Bk protein
  • l(2)37Bl protein
  • l(2)37Ch protein
  • l(2)amd protein
  • l(2)amd alpha-methyldopa hypersensitive protein
  • l(2)amd[H] protein
  • l(2)k02104 protein
  • wu:fa56d05 protein
  • wu:fd59h03 protein
  • wu:fk20h01 protein
  • X04695 protein
  • zgc:65801 protein
  • zgc:76929 protein

Protein level used designations for DDC

3,4-Dihydroxyphenylalanine decarboxylase , CG10697-PB , CG10697-PC , CG10697-PD , Ddc-PB , Ddc-PC , Ddc-PD , aromatic L-amino acid decarboxylase , dopa decarboxylase , dopa-decarboxylase , dopadecarboxylase , dopamine decarboxylase , transcription unit No. 3 , CG10501-PA , CG10501-PB , DHPAA synthase , alpha methyl dopa , alpha-methotrexate deficient , alpha-methyl dopa resistant , amd-PA , amd-PB , transcription unit No. 1 , dopa decarboxylase (aromatic L-amino acid decarboxylase) , aromatic-L-amino-acid decarboxylase , Aromatic-L-amino-acid decarboxylase , Ddc-PA , Dvir\\Ddc-PA , Dvir\\GJ17995-PA , GJ17995-PA , aromatic-L-amino-acid decarboxylase-like , aromatic-L-amino acid decarboxylase , aromatic amino acid decarboxylase , AADC , L-aromatic dopa decarboxylase , L-Dopa decarboxylase

GENE ID SPECIES
35190 Drosophila melanogaster
35188 Drosophila melanogaster
420947 Gallus gallus
463409 Pan troglodytes
496742 Xenopus (Silurana) tropicalis
662962 Tribolium castaneum
693677 Macaca mulatta
750094 Pan troglodytes
6634251 Drosophila virilis
100301599 Oryzias latipes
100402255 Callithrix jacchus
100475392 Ailuropoda melanoleuca
100542576 Meleagris gallopavo
100564794 Anolis carolinensis
100597933 Nomascus leucogenys
100135516 Cavia porcellus
406651 Danio rerio
13195 Mus musculus
280762 Bos taurus
1644 Homo sapiens
396857 Sus scrofa
24311 Rattus norvegicus
100126640 Xenopus laevis
606852 Canis lupus familiaris
101106765 Ovis aries
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