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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Kits (27) and DUSP1 Proteins (5) and many more products for this protein.
Showing 10 out of 109 products:
Human Polyclonal DUSP1 Primary Antibody for EIA, WB - ABIN360822
Wu, Pew, Zou, Pang, Conzen: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. in The Journal of biological chemistry 2005
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Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368
Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016
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Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653
Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993
Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN1532716
Keyse, Emslie: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. in Nature 1992
The aim of this review is to shed light on the role of four different phosphatases (PTEN (show PTEN Antibodies), PP2A (show PPP2R4 Antibodies), CDC25 (show RASGRF1 Antibodies) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.
The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.
we show that IL-1 (show IL1A Antibodies) induces robust p38a (show MAPK14 Antibodies) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (show MAPK14 Antibodies) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 (show TAB1 Antibodies) and MKP1 through a positive feedback loop.
Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.
Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK (show MAPK14 Antibodies)-mediated overexpression of p-glycoprotein in human ovarian cancer cells.
silencing of IL1B (show IL1B Antibodies) plus dexamethasone-induced DUSP1 significantly reduced IRF1 (show IRF1 Antibodies) expression. IL1B (show IL1B Antibodies)-induced expression of CXCL10 (show CXCL10 Antibodies) was largely insensitive to dexamethasone, whereas other DUSP1-enhanced, IRF1 (show IRF1 Antibodies)-dependent mRNAs showed various degrees of repression.
dexamethasone-induced DUSP1 acts via p38 MAPK (show MAPK14 Antibodies) to switch on the mRNA destabilizing function of protein-tristetraprolin (show ZFP36 Antibodies) to repress pro-inflammatory cytokine secretion from ASM (show SMPD1 Antibodies) cells
LPS (show IRF6 Antibodies) tolerance interferes with TLR4 (show TLR4 Antibodies) signaling by inhibiting Lyn (show LYN Antibodies) and c-Src (show SRC Antibodies) phosphorylation and their recruitment to TLR4 (show TLR4 Antibodies), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Antibodies), PTPN22 (show PTPN22 Antibodies), PTP1B (show PTPN1 Antibodies) and MKP1.
This study shows that RIG-I (show DDX58 Antibodies) activation results in MKP-1-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (show CRK Antibodies)-HSP27 (show HSPB1 Antibodies), c-Jun (show JUN Antibodies) and rpS6 (show RPS6 Antibodies) pathways
c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 Antibodies) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.
PTHrP (show PTHLH Antibodies) counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (show ADORA2A Antibodies) signaling regulates both basal and LPS (show TLR4 Antibodies)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Antibodies) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (show NR4A1 Antibodies) induction is dependent on ERK1/2 (show MAPK1/3 Antibodies) and that MKP-1 negatively regulates this induction.
MKP-1 negatively regulates chemokine (show CCL1 Antibodies)-driven osteoclast formation and subsequent bone resorption in response to LPS (show TLR4 Antibodies) stimulation
results suggest that the p38alpha (show MAPK14 Antibodies)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.
DUSP1 and tristetraprolin (show ZFP36 Antibodies) cooperate to regulate macrophage responses to lipopolysaccharide.
MKP-1 regulated the expression of MMP-12 (show MMP12 Antibodies).
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (show MAPK1/3 Antibodies)-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN Antibodies) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 Antibodies) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1