anti-Dual Specificity Phosphatase 1 (DUSP1) Antibodies

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Kits (28) and DUSP1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DUSP1 1843 P28562
DUSP1 19252 P28563
DUSP1 114856 Q64623
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-DUSP1 Antibodies at antibodies-online.com

Showing 10 out of 111 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184638 (3.8µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. ABIN184638 (0.3µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse lymphoma tissue labeled with Anti-DUSP1/MKP-1 Polyclonal Antibody, Unconjugated (ABIN735368) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using MKP1 (Phospho-Ser359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using MKP1 (Ab-359) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MKP1 (Ab-359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$417.45
Details
Human Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, WB The anti-DUSP1 Pab (ABIN392905) is used in Western blot to detect DUSP1 in 293 cell lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB ABIN257653 staining (2µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane). Western Blot: MKP-1/DUSP1 Antibody [ABIN257653] - (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details

DUSP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, ,
,
, , , , , , , , , , , , , , , ,
Mouse (Murine) ,
,

, , , , , , , , , , , , ,
Rat (Rattus) ,
,

, , , , , , , , , , , , ,

Top referenced anti-DUSP1 Antibodies

  1. Human Polyclonal DUSP1 Primary Antibody for EIA, WB - ABIN360822 : Wu, Pew, Zou, Pang, Conzen: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 360822

  2. Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368 : Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016 (PubMed)
    Show all 2 references for 735368

  3. Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519 : Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014 (PubMed)

  4. Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653 : Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993 (PubMed)

  5. Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN1532716 : Keyse, Emslie: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. in Nature 1992 (PubMed)

More Antibodies against DUSP1 Interaction Partners

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.

  2. Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.

  3. Increased MAP2K6 (show MAP2K6 Antibodies), MAP4K3 (show MAP4K3 Antibodies), and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.

  4. The aim of this review is to shed light on the role of four different phosphatases (PTEN (show PTEN Antibodies), PP2A (show PPP2R4 Antibodies), CDC25 (show RASGRF1 Antibodies) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

  5. Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.

  6. The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.

  7. we show that IL-1 (show IL1A Antibodies) induces robust p38a (show MAPK14 Antibodies) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (show MAPK14 Antibodies) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 (show TAB1 Antibodies) and MKP1 through a positive feedback loop.

  8. Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.

  9. Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK (show MAPK14 Antibodies)-mediated overexpression of p-glycoprotein in human ovarian cancer cells.

  10. silencing of IL1B (show IL1B Antibodies) plus dexamethasone-induced DUSP1 significantly reduced IRF1 (show IRF1 Antibodies) expression. IL1B (show IL1B Antibodies)-induced expression of CXCL10 (show CXCL10 Antibodies) was largely insensitive to dexamethasone, whereas other DUSP1-enhanced, IRF1 (show IRF1 Antibodies)-dependent mRNAs showed various degrees of repression.

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 Antibodies) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.

  2. PTHrP (show PTHLH Antibodies) counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.

  3. A2AR (show ADORA2A Antibodies) signaling regulates both basal and LPS (show TLR4 Antibodies)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.

  4. these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Antibodies) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis

  5. Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.

  6. Nr4a1 (show NR4A1 Antibodies) induction is dependent on ERK1/2 (show MAPK1/3 Antibodies) and that MKP-1 negatively regulates this induction.

  7. MKP-1 negatively regulates chemokine (show CCL1 Antibodies)-driven osteoclast formation and subsequent bone resorption in response to LPS (show TLR4 Antibodies) stimulation

  8. results suggest that the p38alpha (show MAPK14 Antibodies)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.

  9. DUSP1 and tristetraprolin (show ZFP36 Antibodies) cooperate to regulate macrophage responses to lipopolysaccharide.

  10. MKP-1 regulated the expression of MMP-12 (show MMP12 Antibodies).

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (show MAPK1/3 Antibodies)-mediated aldosterone production in response to the hormone.

Pig (Porcine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC (show FYN Antibodies) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 Antibodies) activity at submaximal values.

DUSP1 Antigen Profile

Protein Summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1) antibody
  • dual specificity phosphatase 1 (dusp1) antibody
  • dual specificity phosphatase 1 (Dusp1) antibody
  • 3CH134 antibody
  • cb269 antibody
  • CL100 antibody
  • DUSP1 antibody
  • erp antibody
  • HVH1 antibody
  • id:ibd2586 antibody
  • mkp-1 antibody
  • Mkp1 antibody
  • PTPN10 antibody
  • Ptpn16 antibody
  • sb:cb269 antibody
  • U19515 antibody
  • wu:fd19g02 antibody
  • wu:fe50g09 antibody
  • zgc:55920 antibody

Protein level used designations for DUSP1

dual specificity protein phosphatase 1 , dual specificity phosphatase 1 , mkp-1 , MAP kinase phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , mitogen-activated protein kinase phosphatase-1 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , MAPK phosphatase 1

GENE ID SPECIES
374192 Gallus gallus
471742 Pan troglodytes
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
406340 Danio rerio
1843 Homo sapiens
19252 Mus musculus
114856 Rattus norvegicus
489117 Canis lupus familiaris
539175 Bos taurus
100522469 Sus scrofa
Selected quality suppliers for anti-DUSP1 (DUSP1) Antibodies
Did you look for something else?