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Dual Specificity Phosphatase 9 Proteins (DUSP9)

The protein encoded by DUSP9 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP9 Antibodies (56) and DUSP9 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUSP9 1852 Q99956
Mouse DUSP9 DUSP9 75590  
Rat DUSP9 DUSP9 293847  
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Top DUSP9 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

DUSP9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Dual Specificity Phosphatase 9 (DUSP9) Interaction Partners

Human Dual Specificity Phosphatase 9 (DUSP9) interaction partners

  1. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells.

  2. A possible use for DUSP9 as CIMP marker.

  3. DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia.

  4. The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes.

  5. decreased expression of DUSP-9 is associated with poor prognosis in ccRCC.

  6. DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK (show MAPK1 Proteins) signaling through both ERK1/2 and p38alpha (show MAPK14 Proteins) in vivo

  7. 2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented

  8. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP

Mouse (Murine) Dual Specificity Phosphatase 9 (DUSP9) interaction partners

  1. we have identified in this study the MAPK (show MAPK1 Proteins) phosphatase Dusp9 as selectively expressed in mouse pDCs.

  2. these findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.

  3. DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK (show MAPK1 Proteins) signaling through both ERK1/2 and p38alpha (show MAPK14 Proteins) in vivo

  4. negatively regulates insulin (show INS Proteins) signaling and, consequently, may contribute to the pathogenesis of insulin (show INS Proteins) resistance

  5. DUSP9/MKP-4 is essential for placental organogenesis but is otherwise dispensable for mammalian embryonic development.

  6. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP

  7. Data show that Dusp9 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.

  8. Dusp9 has a protective effect against the development of insulin (show INS Proteins) resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin (show INS Proteins) resistance, such as ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins)

DUSP9 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Gene names and symbols associated with DUSP9

  • dual specificity phosphatase 9 (DUSP9)
  • dual specificity phosphatase 9 (LOC100352814)
  • dual specificity phosphatase 9 (Dusp9)
  • Dusp4 protein
  • DUSP9 protein
  • MKP-4 protein
  • MKP4 protein
  • Mpk4 protein
  • Pyst3 protein

Protein level used designations for DUSP9

dual specificity phosphatase 9 , dual specificity protein phosphatase 9 , map kinase phosphatase 4 , mitogen-activated protein kinase phosphatase 4 , serine/threonine specific protein phosphatase , dual-specificity MAP kinase phosphatase 4

GENE ID SPECIES
492240 Canis lupus familiaris
614306 Bos taurus
696161 Macaca mulatta
740713 Pan troglodytes
100352814 Oryctolagus cuniculus
1852 Homo sapiens
75590 Mus musculus
293847 Rattus norvegicus
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