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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Proteins (9) and SIAH1 Kits (3) and many more products for this protein.
Showing 10 out of 98 products:
Human Polyclonal SIAH1 Primary Antibody for IP, ELISA - ABIN268796
Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008
Show all 6 references for ABIN268796
Cow (Bovine) Polyclonal SIAH1 Primary Antibody for EIA, IP - ABIN782894
Sroka, Voigt, Deeg, Reed, Schulz, Bhr, Kermer: BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution. in Journal of neurochemistry 2009
Show all 5 references for ABIN782894
Human Polyclonal SIAH1 Primary Antibody for EIA, WB - ABIN954801
Wen, Yang, Song, Li, Yao, Chen, Zhao, Lu, Zhu, Wang: The expression of SIAH1 is downregulated and associated with Bim and apoptosis in human breast cancer tissues and cells. in Molecular carcinogenesis 2010
Show all 3 references for ABIN954801
Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN184675
Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 2 references for ABIN184675
Human Polyclonal SIAH1 Primary Antibody for ELISA, WB - ABIN1533986
Hu, Chung, Glover, Valentine, Look, Fearon: Characterization of human homologs of the Drosophila seven in absentia (sina) gene. in Genomics 1998
Cow (Bovine) Polyclonal SIAH1 Primary Antibody for WB - ABIN2778297
Avraham, Szargel, Eyal, Rott, Engelender: Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation. in The Journal of biological chemistry 2005
SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR
Data indicate that ubiquitin ligase Siah as a regulator of to Mesenchymal Transition (EMT (show ITK Antibodies)) by controlling the abundance of the key transcription factor Zeb1 (show ZEB1 Antibodies), while Siah itself is subject to regulation by EMT (show ITK Antibodies)-inducing factors.
miRNA network regulates SIAH1 in in colorectal metastasis tissues.
CDK2 (show CDK2 Antibodies) up-regulates the protein level of KLF10 (show KLF10 Antibodies) through reducing its association with SIAH1, a KLF10 (show KLF10 Antibodies) E3-ubiqutin ligase involved in proteasomal degradation.
molecular basis of Siah1 and Siah2 (show SIAH2 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) substrate specificity
Siah1 is a substrate of ASK1 for activation of the GAPDH-Siah1 oxidative stress signaling cascade.
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1