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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Additionally we are shipping Elastase, Neutrophil Expressed Kits (91) and Elastase, Neutrophil Expressed Proteins (19) and many more products for this protein.
Showing 10 out of 105 products:
Human Polyclonal ELANE Primary Antibody for EIA, WB - ABIN953688
Källquist, Rosén, Nordenfelt, Calafat, Janssen, Persson, Hansson, Olsson: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. in Experimental cell research 2010
Show all 4 references for ABIN953688
Human Monoclonal ELANE Primary Antibody for EIA, Func - ABIN111823
Durant, Pederzoli, Lepelletier, Canteloup, Nusbaum, Lesavre, Witko-Sarsat: Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. in Journal of leukocyte biology 2004
Show all 2 references for ABIN111823
Results indicate targeting of a population of neutrophil elastase (NE) to the plasma membrane and internalization dependent on the C-terminal NE pro-peptide.
An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH (show SAMSN1 Antibodies) and could serve as a novel marker to predict NASH (show SAMSN1 Antibodies) in humans
Neutrophil elastase activity is deleterious for airway epithelial cell homeostasis.
insights into the PPE and HNE inhibition
Different ELANE mutants show specific activation of different UPR pathways in congenital neutropenia.
Neutrophil elastase was increased in the saliva (show RAG1AP1 Antibodies) from COPD (show ARCN1 Antibodies) patients and additionally distinguished smoking status.
Paternal Somatic Mosaicism of a Novel Frameshift Mutation in ELANE Causing Severe Congenital Neutropenia.
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors.
analysis of the mechanistic link between neutrophil elastase expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1beta (show IL1B Antibodies) secretion from endothelial cells
In patients with carotid plaques, both circulating and intraplaque polymorphonuclear neutrophils produce IL-8, VEGF and elastase, which are crucial for plaque development and progression.
Serine protease (show F2 Antibodies) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock
Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration
results of ultrasound studies using the elastase and AngII apoE (show APOE Antibodies) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity
SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.
In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions
Lung cancer promotion by inflammation is partly mediated by activation of the IL-8 (show IL8 Antibodies)/CXCR2 (show CXCR2 Antibodies) pathway and subsequent recruitment of neutrophils and release of neutrophil elastase.
a neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
elastase 2, neutrophil
, neutrophil elastase
, elastase, neutrophil expressed
, chymotrypsin-like elastase family member 2A
, pancreatic elastase II
, PMN elastase
, bone marrow serine protease
, granulocyte-derived elastase
, human leukocyte elastase
, leukocyte elastase
, polymorphonuclear elastase
, serine protease