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EED encodes a member of the Polycomb-group (PcG) family. Additionally we are shipping Embryonic Ectoderm Development Kits (26) and Embryonic Ectoderm Development Proteins (14) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal EED Primary Antibody for EIA, IF - ABIN1449991
Rietzler, Bittner, Kolanus, Schuster, Holzmann: The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. in The Journal of biological chemistry 1998
Show all 4 references for ABIN1449991
Human Polyclonal EED Primary Antibody for IF, WB - ABIN2776407
Rakotobe, Violot, Hong, Gouet, Boulanger: Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED. in Virology journal 2008
Human Monoclonal EED Primary Antibody for ELISA, WB - ABIN522175
Martin, Popov, Aguilo, OLoghlen, Raguz, Snijders, Dharmalingam, Li, Thymiakou, Carroll, Zeisig, So, Peters, Episkopou, Walsh, Gil: Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. in The EMBO journal 2013
These results suggest that the SNPs of the EED gene might not be associated with susceptibility to CRC (show CALR Antibodies).
An integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 (show PRC1 Antibodies) and 2, is reported.
Data show that overall enhancer of zeste 2 (EZH2 (show EZH2 Antibodies)), embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12 (show SUZ12 Antibodies)) expression in the colorectal cancer (CRC (show CALR Antibodies)) tissues was significantly increased than in the non-cancerous tissue.
EED, a component of Polycomb (show CBX2 Antibodies) repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (show HIST3H3 Antibodies) (H3K27), was involved in epithelial-mesenchymal transition (EMT (show ITK Antibodies)) of cancer cells induced by Transforming Growth Factor-beta (TGF-beta).
Polycomb (show CBX2 Antibodies) repressive complex 2 is recurrently inactivated through EED or SUZ12 (show SUZ12 Antibodies) loss in malignant peripheral nerve sheath tumors.
EZH2 (show EZH2 Antibodies)-EED is necessary and sufficient for binding to the lncRNA HOTAIR.
Although inactivating mutations in PRC2-encoding genes EZH2 (show EZH2 Antibodies), EED, and SUZ12 (show SUZ12 Antibodies) are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mutations in EZH2 (show EZH2 Antibodies) are frequently observed in B-cell lymphoma.
EED mutants impair polycomb (show CBX2 Antibodies) repressive complex 2 and is associated with myelodysplastic syndrome and related neoplasms
Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.
Genetic defects in PRC2 components other than EZH2 (show EZH2 Antibodies) are not common in myeloid malignancies.
EED affects the lymphoid versus myeloid decision processes within the lymphomyeloid lineage
Inactivation of Eed impedes MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-mediated leukemogenesis through Cdkn2a (show CDKN2A Antibodies)-dependent and Cdkn2a (show CDKN2A Antibodies)-independent mechanisms in a murine model.
Data suggest that Eed (embryonic ectoderm development) is necessary to silence the pluripotency network during differentiation.
a microRNA encoded by the imprinted Dlk1 (show DLK1 Antibodies)-Dio3 (show DIO3 Antibodies) region of mouse chromosome 12, miR (show MLXIP Antibodies)-323-3p, targets Eed (embryonic ectoderm development) mRNA.
Ectopic gain of EED along with depletion of KDM6B (show Kdm6b Antibodies) in preimplantation mouse embryos abrogates CDX2 (show CDX2 Antibodies) and GATA3 (show GATA3 Antibodies) gene expression in the nascent trophoectoderm lineage.
It was shown that Ring1B (show RNF2 Antibodies) interacted with multiple complexes in embryonic stem cells. Although H2A.Z (show H2AFZ Antibodies) co-localized with Eed, Ring1B (show RNF2 Antibodies) and CpG islands in chromatin, H2A.Z (show H2AFZ Antibodies) still blanketed polycomb (show CBX2 Antibodies) target loci in the absence of Suz12 (show SUZ12 Antibodies), Eed, or Ring1B (show RNF2 Antibodies).
Data indicate that binding of EZH2 (show EZH2 Antibodies), SUZ12 (show SUZ12 Antibodies) and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
The role of polycomb (show CBX2 Antibodies) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.
identify polycomb-like 2 (show MTF2 Antibodies) and Polycomb (show CBX2 Antibodies) Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb (show CBX2 Antibodies) Repressive Complex 2 and polycomb-like 2 (show MTF2 Antibodies)]
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.
polycomb protein eed
, embryonic ectoderm development
, WD protein associating with integrin cytoplasmic tails 1
, polycomb protein EED
, embryonic ectoderm development protein variant 1
, polycomb protein eed-B
, embryonic ectoderm development protein
, lethal, Chr 7, Rinchik 5
, polycomb protein eed-A