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Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Proteins (EIF2AK4)

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies (107) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2AK4 440275 Q9P2K8
EIF2AK4 27103 Q9QZ05
EIF2AK4 114859  
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Top Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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EIF2AK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Interaction Partners

Human Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. IDO (show IDO1 Proteins), through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2 (show GLS2 Proteins)

  2. EIF2AK4 mutation was associated with pulmonary veno-occlusive disease. PVOD patients who were not significantly exposed to trichloroethylene were more likely to harbour EIF2AK4 mutations.

  3. Data show that sequenced eukaryotic translation initiation factor 2 alpha kinase 4 protein (EIF2AK4) with a homozygous mutation in all five families: c.3344C>T(p.P1115L).

  4. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  5. Upon deprivation of various amino acids, activated GCN2 up-regulates ATF4 (show ATF4 Proteins) to induce expression of the stress response protein Sestrin2, which is required to sustain repression of mTORC1 by blocking its lysosomal localization

  6. IDO (show IDO1 Proteins) through GCN2 kinase activation inhibits CD4 (show CD4 Proteins)(+) T-cell proliferation and down-regulates key enzymes that directly or indirectly promote FA synthesis, a prerequisite for CD4 (show CD4 Proteins)(+) T-cell proliferation and differentiation into effector cell lineages.

  7. GCN2 can exert its proapoptotic function in cancer cell death by posttranslational mechanisms.

  8. GCN2 activation and phosphorylation of eIF2alpha (show EIF2A Proteins) in response to mTORC1 inhibition are necessary for autophagy.

  9. This study is the first to examine the perceptual response to CPET in patients with PVOD who were carriers of EIF2AK4 mutations compared with PAH patients matched for resting haemodynamics and pulmonary function

  10. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Dietary EAA sensing depends on physiologic need, but not GCN2.

  2. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  3. acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2; hence, results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2

  4. Gcn2 & Atf4 (show ATF4 Proteins) are involved in L-proline metabolism regulation in embryonic stem cells.

  5. Metabolic stress signals delivered by GCN2 inhibit innate inflammatory responses to apoptotic cells, restricting adaptive immunity and preventing autoimmunity. GCN2 activation by halofunginone halobromide potently reduced autoimmune reactivity.

  6. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  7. Data indicate that the crystal structures of murine and yeast GCN2 protein kinase C-terminal domain (CTD) showed dimers.

  8. The results suggest that the GCN2 kinase-dependent sensing of indoleamine 2,3-dioxygenase activity represents an important trigger to the experimental autoimmune encephalomyelitis remission phase.

  9. Deletion of the eIF2alpha Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.

  10. The present study provides the first direct evidence that inhibition of GCN2 activity by GCN2 gene deletion attenuates the development of heart failure.

Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Protein Profile

Protein Summary

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999

Gene names and symbols associated with EIF2AK4

  • eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4)
  • eukaryotic translation initiation factor 2 alpha kinase 4 (eif2ak4)
  • eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4)
  • 2610011M03 protein
  • EIF2AK4 protein
  • GCN2 protein
  • Gcn2-like protein
  • MGCN2 protein

Protein level used designations for EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4 , eukaryotic translation initiation factor 2-alpha kinase 4-like , GCN2 protein , GCN2 eIF2alpha kinase , GCN2-like protein , eukaryotic translation initiation factor 2-alpha kinase 4

GENE ID SPECIES
423285 Gallus gallus
453321 Pan troglodytes
478257 Canis lupus familiaris
513829 Bos taurus
100392095 Callithrix jacchus
579979 Strongylocentrotus purpuratus
100031798 Monodelphis domestica
100088614 Ornithorhynchus anatinus
100187226 Ciona intestinalis
100232582 Taeniopygia guttata
100358284 Oryctolagus cuniculus
100428309 Macaca mulatta
100552145 Anolis carolinensis
100606228 Nomascus leucogenys
100216307 Xenopus (Silurana) tropicalis
440275 Homo sapiens
27103 Mus musculus
114859 Rattus norvegicus
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