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EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies (108) and many more products for this protein.
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IDO (show IDO1 Proteins), through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2 (show GLS2 Proteins)
EIF2AK4 mutation was associated with pulmonary veno-occlusive disease. PVOD patients who were not significantly exposed to trichloroethylene were more likely to harbour EIF2AK4 mutations.
Data show that sequenced eukaryotic translation initiation factor 2 alpha kinase 4 protein (EIF2AK4) with a homozygous mutation in all five families: c.3344C>T(p.P1115L).
Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.
Upon deprivation of various amino acids, activated GCN2 up-regulates ATF4 (show ATF4 Proteins) to induce expression of the stress response protein Sestrin2, which is required to sustain repression of mTORC1 by blocking its lysosomal localization
IDO (show IDO1 Proteins) through GCN2 kinase activation inhibits CD4 (show CD4 Proteins)(+) T-cell proliferation and down-regulates key enzymes that directly or indirectly promote FA synthesis, a prerequisite for CD4 (show CD4 Proteins)(+) T-cell proliferation and differentiation into effector cell lineages.
GCN2 can exert its proapoptotic function in cancer cell death by posttranslational mechanisms.
GCN2 activation and phosphorylation of eIF2alpha (show EIF2A Proteins) in response to mTORC1 inhibition are necessary for autophagy.
This study is the first to examine the perceptual response to CPET in patients with PVOD who were carriers of EIF2AK4 mutations compared with PAH patients matched for resting haemodynamics and pulmonary function
p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis
Dietary EAA sensing depends on physiologic need, but not GCN2.
acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2; hence, results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2
Gcn2 & Atf4 (show ATF4 Proteins) are involved in L-proline metabolism regulation in embryonic stem cells.
Metabolic stress signals delivered by GCN2 inhibit innate inflammatory responses to apoptotic cells, restricting adaptive immunity and preventing autoimmunity. GCN2 activation by halofunginone halobromide potently reduced autoimmune reactivity.
Data indicate that the crystal structures of murine and yeast GCN2 protein kinase C-terminal domain (CTD) showed dimers.
The results suggest that the GCN2 kinase-dependent sensing of indoleamine 2,3-dioxygenase activity represents an important trigger to the experimental autoimmune encephalomyelitis remission phase.
Deletion of the eIF2alpha Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.
The present study provides the first direct evidence that inhibition of GCN2 activity by GCN2 gene deletion attenuates the development of heart failure.
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999
eukaryotic translation initiation factor 2 alpha kinase 4
, eukaryotic translation initiation factor 2-alpha kinase 4-like
, GCN2 protein
, GCN2 eIF2alpha kinase
, GCN2-like protein
, eukaryotic translation initiation factor 2-alpha kinase 4