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FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXW8 Kits (12) and FBXW8 Proteins (3) and many more products for this protein.
Showing 10 out of 48 products:
Human Polyclonal FBXW8 Primary Antibody for EIA, IHC (p) - ABIN952296
Tsutsumi, Kuwabara, Arai, Xiao, Decaprio: Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. in Molecular and cellular biology 2008
Show all 3 references for ABIN952296
Human Polyclonal FBXW8 Primary Antibody for ELISA, WB - ABIN565252
Wei, Yang, Chuang, Yang, Kulp, Lu, Lai, Chen: A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. in The Journal of biological chemistry 2008
Show all 2 references for ABIN565252
Cow (Bovine) Polyclonal FBXW8 Primary Antibody for WB - ABIN2786275
Lin, Fu, Zhao, Lin, Zou, Liu, Zhu, Wang, Yu: Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. in Molecular biology reports 2011
Show all 2 references for ABIN2786275
Human Polyclonal FBXW8 Primary Antibody for ICC, IF - ABIN4310808
Halbach, Stehning, Damrath, Jendrach, Şen, Başak, Auburger: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. in PLoS ONE 2015
Show all 2 references for ABIN4310808
Human Polyclonal FBXW8 Primary Antibody for FACS, IHC (p) - ABIN654676
Wang, Chen, Lin, Li, Zhou, Liu, Logsdon, Jin, Abbruzzese, Tan, Wang: The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. in The Journal of biological chemistry 2014
FBXW8 and PARK2 (show PARK2 Antibodies) are sequestrated into insolubility by ATXN2 (show ATXN2 Antibodies) PolyQ expansions, but only FBXW8 expression is dysregulated
findings will shed light the role to mechanism of miR (show MLXIP Antibodies)-218 in regulating JEG-3 cells proliferation via miR (show MLXIP Antibodies)-218/Fbxw8 axis, and miR (show MLXIP Antibodies)-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future
CUL7 (show CUL7 Antibodies)/Fbxw8 ubiquitin ligase-mediated HPK1 (show MAP4K1 Antibodies) degradation revealed a direct link and novel role of CUL7 (show CUL7 Antibodies)/Fbxw8 ubiquitin ligase in the MAPK (show MAPK1 Antibodies) pathway, which plays a critical role in cell proliferation and differentiation.
Dysregulation of Cul7 (show CUL7 Antibodies) and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction.
Growth factor-stimulated TBC1D3 (show TBC1D3 Antibodies) ubiquitination and degradation are regulated by its interaction with CUL7 (show CUL7 Antibodies)-Fbw8.
Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.
FBXW8 plays an essential role in cancer cell proliferation throug (show CCND1 Antibodies)h proteolysis of cyclin D1. It may (show CDK1 Antibodies) present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively.
FBXW8-CUL7 (show CUL7 Antibodies) complex plays a significant role in growth control
mTORC2 (show CRTC2 Antibodies) negatively feeds back to IRS-1 (show IRS1 Antibodies) via control of Fbw8 stability and localization.
our data support the concept that expanded ATXN2 (show ATXN2 Antibodies) undergoes progressive insolubility and affects PABPC1 (show PABPC1 Antibodies) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.
Depletion of FBXW8 caused a significant accumulation of cyclin D1 (show CCND1 Antibodies), as well as sequestration of CDK1 (show CDK1 Antibodies) in the cytoplasm. This resulted in a severe reduction of cell proliferation.
Cul7 (show CUL7 Antibodies) forms a heterodimeric complex with Cul1 (show CUL1 Antibodies) in a manner dependent on Fbxw8.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
F-box and WD-40 domain protein 8
, F-box and WD-40 domain-containing protein 8
, F-box only protein 29
, F-box/WD repeat-containing protein 8
, F-box protein FBX29