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Functions in an early step of clathrin-mediated endocytosis. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal FCHO2 Primary Antibody for IHC, IHC (p) - ABIN4311214
Sochacki, Dickey, Strub, Taraska: Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells. in Nature cell biology 2017
Fcho1 (show FCHO1 Antibodies)/2Eps15/RAP-2 (show RAP2A Antibodies) ternary complexes to facilitate conformational activation of AP-2 (show GTF3A Antibodies) by the Fcho1 (show FCHO1 Antibodies)/2 interdomain linker to promote AP-2 (show GTF3A Antibodies) cargo engagement.
The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2 (show GTF3A Antibodies).
FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 (show DAB2 Antibodies) is needed for LDLR (show LDLR Antibodies) endocytosis under conditions of low AP2 (show GTF3A Antibodies).
show that the mu-homology domain of FCHO1 (show FCHO1 Antibodies)/2 represents an endocytic interaction hub
FCHO2 regulates clathrin-mediated endocytosis through its interactions with membranes and Eps15 (show EPS15 Antibodies).
study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
FCH domain only 2
, FCH domain only protein 2