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anti-Farnesyl Diphosphate Synthase (FDPS) Antibodies

FDPS encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. Additionally we are shipping FDPS Kits (12) and FDPS Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FDPS 2224 P14324
FDPS 83791 P05369
FDPS 110196 Q920E5
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Top anti-FDPS Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 10 to 12 Days
$375.38
Details
Human Rabbit Un-conjugated EIA, WB FDPS Antibody (N-term) western blot analysis in 293 cell line lysates (35µg/lane).This demonstrates the FDPS antibody detected the FDPS protein (arrow). Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (N-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-FDPS Pab (ABIN389054) is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. Data is kindly provided by Dr. Masaru Harada from Stanford University (Palo Alto, CA). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center )(ABIN389054), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (D31) (ABIN1882080) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene. Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (D31) (ABIN1882080) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB FDPS Antibody (N-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FDPS antibody detected the FDPS protein (arrow). Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Host: RabbitTarget Name: FDPSAntibody Dilution: 1.0ug/mlSample Tissue: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE antibody diluted at 1:10000 WB Image Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE antibody diluted at 1:3000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details

FDPS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FDPS Antibodies

  1. Human Polyclonal FDPS Primary Antibody for IHC (p), WB - ABIN389054 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 8 references for ABIN389054

  2. Human Polyclonal FDPS Primary Antibody for EIA, WB - ABIN952387 : Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. in The Biochemical journal 2010 (PubMed)
    Show all 5 references for ABIN952387

  3. Human Polyclonal FDPS Primary Antibody for IF, IHC (p) - ABIN1882080 : Nomura, Miyajima, Sazuka, Tanaka, Kawarabayasi, Sato, Nagase, Seki, Ishikawa, Tabata et al.: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature ... in DNA research : an international journal for rapid publication of reports on genes and genomes 1995 (PubMed)
    Show all 4 references for ABIN1882080

  4. Human Polyclonal FDPS Primary Antibody for EIA, IHC (p) - ABIN357713 : Wilkin, Kutsunai, Edwards et al.: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ... in The Journal of biological chemistry 1990 (PubMed)
    Show all 4 references for ABIN357713

  5. Human Polyclonal FDPS Primary Antibody for WB - ABIN658784 : Romanelli, Lorenzi, Sangalli, Diani, Mottes: Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region. in Genomics 2009 (PubMed)

  6. Human Polyclonal FDPS Primary Antibody for EIA, IHC (p) - ABIN357714 : Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Antibodies against FDPS Interaction Partners

Fruit Fly (Drosophila melanogaster) Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. mitochondrial targeting of FPS may be widespread among eukaryotes

  2. Farnesyl diphosphate synthase (FPPS) of the dipteran Drosophila melanogaster has been cloned and its catalytic properties have been assessed.

Human Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.

  2. our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels.

  3. Results suggest that polymorphisms of the FDPS gene may influence the bone response to drugs targeting the mevalonate pathway, like statins.

  4. A co-crystal structure of human farnesyl pyrophosphate synthase in complex with a bisphosphonate and two molecules of inorganic phosphate.

  5. The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP (show IPP Antibodies) site and may be of interest as anticancer and antiinfective drug leads.

  6. These observations suggest that an increase in the expression of endogenous FPPS could confer at least partial resistance to the pharmacological effect of N-BP drugs such as ZOL in vivo

  7. LRP5 (show LRP5 Antibodies) and FDPS loci age-specifically affect skeletal traits in healthy fertile women.

  8. Data indicate compounds represent a new structural class of farnesyl pyrophosphate synthase (hFPPS) inhibitors and suggest a development of therapeutics.

  9. The iPA-driven modulation of FDPS can cause an enhancement of post-translational prenylation essential for the biological activity of key proteins in NK signaling and effector functions, such as Ras.

  10. FPPS was more highly expressed in prostate cancer vs. normal prostate tissue. The association of FPPS with established histopathological risk parameters and biochemical recurrence implicates a contribution of the mevalonate pathway to PC progression.

Mouse (Murine) Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.

  2. identified a single putative direct repeat 4 (DR4 (show HLADRB4 Antibodies)) LXR (show NR1H3 Antibodies) response element in the FPS (show FES Antibodies) promoter isolated from immortalized murine astrocyte P11 (show S100A10 Antibodies)-5 cells

FDPS Antigen Profile

Protein Summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with FDPS

  • Farnesyl pyrophosphate synthase (Fpps) antibody
  • farnesyl diphosphate synthase (fdps) antibody
  • farnesyl pyrophosphate synthetase (MGG_08649) antibody
  • farnesyl pyrophosphate synthetase (TP03_0857) antibody
  • farnesyl pyrophosphate synthetase (Tb09.160.4300) antibody
  • farnesyl pyrophosphate synthetase (NCU01175) antibody
  • farnesyl pyrophosphate synthetase (BBOV_I000120) antibody
  • FDP synthase (fps) antibody
  • Farnesyl pyrophosphate synthetase (fpps) antibody
  • farnesyl diphosphate synthase (FDPS) antibody
  • farnesyl diphosphate synthase (Fdps) antibody
  • farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS) antibody
  • farnesyl diphosphate synthetase (Fdps) antibody
  • farnesyl pyrophosphate synthase1 (fps1) antibody
  • (2E antibody
  • 16.m00760 antibody
  • 6030492I17Rik antibody
  • Ac2-125 antibody
  • AI256750 antibody
  • CG12389 antibody
  • DDBDRAFT_0206220 antibody
  • DDBDRAFT_0215017 antibody
  • DDB_0206220 antibody
  • DDB_0215017 antibody
  • Dmel\\CG12389 antibody
  • DmFPPS antibody
  • DmFPPSase antibody
  • DmFPS antibody
  • Fdpsl1 antibody
  • FPPS antibody
  • fps antibody
  • l(2)k06103 antibody
  • mKIAA1293 antibody
  • NCU01175.1 antibody
  • v(2)k03514 antibody

Protein level used designations for FDPS

farnesyl pyrophosphate synthase , CG12389-PA , Fpps-PA , farnesyl diphosphate synthase , farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) , farnesyl pyrophosphate synthetase , Farnesyl pyrophosphate synthetase , (2E,6E)-farnesyl diphosphate synthase , FPP synthase , FPP synthetase , dimethylallyltranstransferase , farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase , geranyltranstransferase , CR 39 , cholesterol-regulated 39 kDa protein , farnesyl diphosphate synthetase , testis-specific farnesyl pyrophosphate synthetase , FPS , 6E)-farnesyl diphosphate synthase , FPPS , GRMZM2G168681 , PCO074380 , PCO074380(592) , PCO074380_ov , PCO074380b , QBB18h08 , geranylgeranyl-diphosphate synthase , gnp_QBB18h08b , gpm430b , prenyltransferase

GENE ID SPECIES
36209 Drosophila melanogaster
548584 Xenopus (Silurana) tropicalis
735190 Xenopus laevis
2678891 Magnaporthe oryzae 70-15
3499793 Theileria parva strain Muguga
3660082 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3877737 Neurospora crassa OR74A
5476865 Babesia bovis T2Bo
8621722 Dictyostelium discoideum AX4
100195349 Salmo salar
2224 Homo sapiens
83791 Rattus norvegicus
281156 Bos taurus
480129 Canis lupus familiaris
425061 Gallus gallus
110196 Mus musculus
541903 Zea mays
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