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The protein encoded by FRK belongs to the TYR family of protein kinases. Additionally we are shipping FRK Proteins (7) and FRK Kits (4) and many more products for this protein.
Showing 10 out of 139 products:
Human Monoclonal FRK Primary Antibody for WB - ABIN2869328
Cance, Craven, Weiner, Liu: Novel protein kinases expressed in human breast cancer. in International journal of cancer. Journal international du cancer 1993
Show all 3 references for ABIN2869328
Human Monoclonal FRK Primary Antibody for IHC, ELISA - ABIN969157
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 2 references for ABIN969157
Cow (Bovine) Polyclonal FRK Primary Antibody for WB - ABIN2785801
Zhang, Gong, Wang, Wang, Ran: [Deoxycholate induces apoptosis in cultured normal human esophageal mucosal epithelial cells]. in Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 2005
Show all 2 references for ABIN2785801
Chicken Polyclonal FRK Primary Antibody for WB - ABIN2774079
Zhang, Wolf-Yadlin, Ross, Pappin, Rush, Lauffenburger, White: Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. in Molecular & cellular proteomics : MCP 2005
Show all 2 references for ABIN2774079
Human Monoclonal FRK Primary Antibody for ELISA, WB - ABIN969494
Cance, Craven, Bergman, Xu, Alitalo, Liu: Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995
Human Polyclonal FRK Primary Antibody for IF, IHC - ABIN1533731
Lee, Wang, Luoh, Wood, Scadden: Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. in Gene 1994
antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn (show FYN Antibodies)-related Src (show SRC Antibodies) family tyrosine kinase (show TXK Antibodies).
our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 (show CCND1 Antibodies) nucleus accumulation and pRb (show RB1 Antibodies) phosphorylation in glioma cells.
FRK over-expression promoted beta-catenin (show CTNNB1 Antibodies) translocation to the plasma membrane, where it formed complex with N-cadherin (show CDH2 Antibodies).
exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 (show STAT3 Antibodies) activation, and cell proliferation sensitive to Src (show SRC Antibodies) inhibitors
Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR (show EGFR Antibodies) interaction.
The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines.
these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion
Genetic variation near FRK/COL10A1 (show COL10A1 Antibodies) and VEGFA (show VEGFA Antibodies) are associated with advanced age-related macular degeneration.
Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs.
Breast cancer cell line proliferation blocked by the Src (show SRC Antibodies)-related Rak tyrosine kinase (show TXK Antibodies)
Characterization of mice deficient in the Src (show SRC Antibodies) family nonreceptor tyrosine kinase (show TYRO3 Antibodies) Frk/rak. Decreases in the circulating levels of T3 but not T4 are reminiscent of euthyroid sick syndrome, a stress-associated clinical condition
The tyrosine kinases Brk/PTK6/Sik (show PTK6 Antibodies), Srm (show SRM Antibodies), Frk/Rak/Gtk/Iyk/Bsk (show EPHA5 Antibodies), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk (show PTK6 Antibodies) family, is highly conserved and distinct.
Experiments with Fyn (show FYN Antibodies)-deficient mice indicate that Fyn (show FYN Antibodies) genotype does not influence ethanol consumption, neither under basal conditions nor following a deprivation period or stress.
These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions.
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Potassium (K+) channel protein alpha 2, voltage dependent
, potassium voltage gated channel shaker related subfamily member 2
, potassium voltage-gated channel subfamily A member 2
, voltage-gated potassium channel subunit Kv1.2
, hypothetical protein LOC583550
, fyn-related kinase
, tyrosine-protein kinase FRK-like
, PTK5 protein tyrosine kinase 5
, nuclear tyrosine protein kinase RAK
, protein-tyrosine kinase 5
, tyrosine-protein kinase FRK
, B-cell src-homology tyrosine kinase
, beta-cell Src-homology tyrosine kinase
, intestine tyrosine kinase
, gastrointestinal-associated kinase
, gastrointestinal-associated tyrosine kinase
, src related tyrosine kinase