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Proton-sensing receptor involved in pH homeostasis. Additionally we are shipping and many more products for this protein.
Showing 10 out of 74 products:
Mouse (Murine) Polyclonal GPR68 Primary Antibody for WB - ABIN1881516
Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. in Journal of the National Cancer Institute 2007
Show all 4 Pubmed References
Cow (Bovine) Polyclonal GPR68 Primary Antibody for IHC (p) - ABIN1048863
Komarova, Pereverzev, Shum, Sims, Dixon: Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Human Polyclonal GPR68 Primary Antibody for IHC (p) - ABIN2475955
Mogi, Tomura, Tobo, Wang, Damirin, Kon, Komachi, Hashimoto, Sato, Okajima: Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. in Journal of pharmacological sciences 2005
data identify a role for GPR68 as a proton sensor that is required for proper enamel formation
coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
Proton-sensing GPCR (show NMUR1 Antibodies)-YAP (show YAP1 Antibodies) Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells
The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms
Provide evidence for the roles of OGR1 and ASIC1a (show ACCN2 Antibodies) in the regulation of intestinal passive Mg(2 (show MUC7 Antibodies)+) absorption.
the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression.
The involvement of ovarian cancer G-protein-coupled receptor 1 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures.
OGR1 activation increased intracellular calcium in transfe (show ATP6AP1 Antibodies)cted HEK293 cells.
It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer.
extracellular acidification induces CTGF (show CTGF Antibodies) production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2 (show CA2 Antibodies)+) mobilization in human airway smooth muscle cells.
In rapidly growing mice, lack of OGR1 leads to increased bone mass with increased bone turnover and a greater increase in bone formation than resorption.
Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.
CaSR (show CASR Antibodies) and OGR1 reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification potentiates OGR1.
acidic pH stimulates cGMP accumulation preferentially through the OGR1/Gq/11 proteins/phospholipase C (show PLC Antibodies)/Ca(2 (show CA2 Antibodies)+)/nNOS (show NOS1 Antibodies) in N1E-115 neuronal cells. Akt (show AKT1 Antibodies)-mediated phosphorylation of nNOS (show NOS1 Antibodies)
OGR1 on dendritic cells is critical for their migration to draining lymph nodes, which, in turn, stimulates Th2 phenotype change and subsequent induction of airway inflammation and hyperreactivity.
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin (show INS Antibodies) secretion.
OGR1 alters the pH-sensitive response of NHE and H+-ATPase (show ATP6AP1 Antibodies) activity in proximal tubules.
regulator of G-protein signaling 18 (show RGS18 Antibodies) acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT (show NFATC1 Antibodies) signaling pathway
OGR1 induces an increase in Ca(i (show CA1 Antibodies)) in response to acidic medium and is a prime candidate for an osteoblast proton sensor.
OGR1's role in osteoclastogenesis is not strong enough to affect overall bone development.
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).
G protein-coupled receptor 68
, ovarian cancer G-protein coupled receptor 1-like
, G-protein coupled receptor 68
, ovarian cancer G protein-coupled receptor, 1
, ovarian cancer G-protein coupled receptor 1
, sphingosylphosphorylcholine receptor
, g protein-coupled receptor RGR1