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anti-G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) (GPSM1) Antibodies

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. Additionally we are shipping G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GPSM1 26086 Q86YR5
GPSM1 246254 Q9R080
GPSM1 67839 Q6IR34
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Top anti-G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GPSM1 AntibodyTitration: 1.0 µg/mL  Positive Control: NCI-H226 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB GPSM1 Antibody (Center)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GPSM1 antibody detected the GPSM1 protein (arrow). GPSM1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPSM1 Antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged GPSM1 is 3 ng/ml as a capture antibody. Western Blot detection against Immunogen (73.48 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details

GPSM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) Interaction Partners

Human G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) (GPSM1) interaction partners

  1. Activator of G-protein Signaling 3 is an important regulator of esophageal squamous cell carcinoma proliferation

  2. Results confirmed that Ric-8A (show RIC8A Antibodies) can directly bind to AGS3S but failed to facilitate Galpha (show SUCLG1 Antibodies)(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha (show SUCLG1 Antibodies)(i/o)-GDP complex in a cellular environment.

  3. High GPSM1 gene methylation is associated with gastric tumor aggressiveness.

  4. Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP (show LEP Antibodies), GPSM1 and SLC16A13 (show SLC16A13 Antibodies).

  5. Our data indicate that decreased expression of AGS3 is correlated with reduced levels of p-CREB (show CREB1 Antibodies) in the apoptotic model. The negative role of AGS3 in cell apoptosis was further confirmed by knocking down AGS3.

  6. these results indicate that GRK6 (show GRK6 Antibodies) complexes with AGS3-Galphai2 (show GNAI2 Antibodies) to regulate CXCR2 (show CXCR2 Antibodies)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  7. These results provide mechanistic insights into how reversible modulation of Galpha (show SUCLG1 Antibodies)(i3) activity by AGS3 and GIV (show CCDC88A Antibodies) maintains the delicate equilibrium between promotion and inhibition of autophagy.

  8. AGS3 receptor coupling to both Galphabetagamma and GPR (show ALDH18A1 Antibodies)-Galpha (show SUCLG1 Antibodies)(i) offer additional flexibility for systems to respond and adapt to challenges and orchestrate complex behaviors

  9. unlike wild-type AGS3, over-expression of an AGS3 mutant lacking this modification fails to enhance macroautophagic activity. These observations imply that AGS3 phosphorylation may participate in the modulation of macroautophagy

  10. These data present AGS3, G-proteins, and mInsc (show INSC Antibodies) as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies.

Mouse (Murine) G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) (GPSM1) interaction partners

  1. We conclude that LPS (show TLR4 Antibodies) priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.

  2. level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3 (show GNAI3 Antibodies), AGS3, or RGS19 (show RGS19 Antibodies); or had been treated with pertussis toxin, were similar to controls

  3. AGS3 has a role in the regulation of G-protein signaling in the immune system

  4. these results indicate that GRK6 (show GRK6 Antibodies) complexes with AGS3-Galphai2 (show GNAI2 Antibodies) to regulate CXCR2 (show CXCR2 Antibodies)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  5. The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease.

  6. These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration.

  7. AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure.

  8. The GPR (show ALDH18A1 Antibodies) motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase (show RACGAP1 Antibodies) activator as initially suggested.

G-Protein Signaling Modulator 1 (AGS3-Like, C. Elegans) (GPSM1) Antigen Profile

Protein Summary

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GPSM1

  • G-protein signaling modulator 1 (GPSM1) antibody
  • G-protein signaling modulator 1 (Gpsm1) antibody
  • G-protein signalling modulator 1 (AGS3-like, C. elegans) (Gpsm1) antibody
  • 1810037C22Rik antibody
  • Ags3 antibody
  • AW107933 antibody

Protein level used designations for GPSM1

G-protein signalling modulator 1 (AGS3-like, C. elegans) , G-protein-signaling modulator 1 , activator of G-protein signaling 3 , G-protein signaling modulator 1 (AGS3-like, C. elegans)

GENE ID SPECIES
26086 Homo sapiens
246254 Rattus norvegicus
67839 Mus musculus
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