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anti-Galactosidase, alpha (GLA) Antibodies

GLA encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Additionally we are shipping GLA Kits (34) and GLA Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GLA 2717 P06280
GLA 363494  
GLA 11605  
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Top anti-GLA Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GLA Antibody Titration: 0.2-1 ug/mlPositive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB GLA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GLA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of GLA antibody (N-term) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of GLA antibody (N-term) (ABIN390687) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified polyclonal antibody. GLA Antibody (N-term) (ABIN390687) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, IHC (p), WB WB Image Galactosidase alpha antibody [N1C2] detects Galactosidase alpha protein by western blot analysis. Rat tissue extracts (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody [N1C2] , diluted at 1:1000. WB Image Galactosidase alpha antibody detects Galactosidase alpha protein by western blot analysis. Whole cell extracts (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody , at a dilution of 1:1000. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: Galactosidase alpha Antibody [NBP1-89796] - Staining of human small intestine shows strong cytoplasmic positivity in glandular cells. Western Blot: alpha-Galactosidase A/GLA Antibody [NBP1-89796] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Lane 4: Human plasma (IgG/HSA depleted) Lane 5: Human liver tissue 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Mouse Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse liver lysates Lane 2: human colon carcinoma lysates probed with Anti Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 44kD. Observed band size: 44kD. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Western Blot: Galactosidase alpha Antibody [NBP2-16576] - Sample (30 ug of whole cell lysate) A: Hela 10% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: Galactosidase alpha Antibody [NBP2-16576] - Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using antibody at 1:100 dilution. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 20 to 21 Days
$308.00
Details
Human Rabbit Un-conjugated IP, IHC (p), ELISA, WB Immunochemical staining of human GLA in human breast carcinoma (from 2 donors) with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human GLA in human prostatic carcinoma with rabbit polyclonal antibody(1µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 20 to 21 Days
$308.00
Details

GLA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GLA Antibodies

  1. Human Polyclonal GLA Primary Antibody for EIA, WB - ABIN453055 : Ioannou, Zeidner, Grace, Desnick: Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility. in The Biochemical journal 1998 (PubMed)
    Show all 2 references for ABIN453055

  2. Cow (Bovine) Polyclonal GLA Primary Antibody for WB - ABIN2785641 : Auray-Blais, Cyr, Ntwari, West, Cox-Brinkman, Bichet, Germain, Laframboise, Melançon, Stockley, Clarke, Drouin: Urinary globotriaosylceramide excretion correlates with the genotype in children and adults with Fabry disease. in Molecular genetics and metabolism 2008 (PubMed)

  3. Human Polyclonal GLA Primary Antibody for IHC, IHC (p) - ABIN4280010 : Xu, Lun, Brignol, Hamler, Schilling, Frascella, Sullivan, Boyd, Chang, Soska, Garcia, Feng, Yasukawa, Shardlow, Churchill, Ketkar, Robertson, Miyamoto, Mihara, Benjamin, Lockhart, Hirato, Fowles et al.: Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice. ... in Molecular therapy : the journal of the American Society of Gene Therapy 2015 (PubMed)

More Antibodies against GLA Interaction Partners

Human Galactosidase, alpha (GLA) interaction partners

  1. we reviewed other small molecules that were reported to have a stabilizing effect on some GLA (show NAT8 Antibodies) missense mutations in vitro and might be developed to act in synergy or as an alternative to 1-deoxygalactonojirimycin

  2. No pathogenic mutations in the coding regions of the GLA (show NAT8 Antibodies) gene were identified in this group of patients and thus no Fabry disease was found in this study.

  3. High desphospho-uncarboxylated matrix Gla protein (show MGP Antibodies) level, reflecting a poor vitamin K status, seems to be associated with kidney damage and may be also a marker of cardiovascular risk in CKD patients

  4. Case Report: Kidney transplantation from a mother with unrecognized Fabry disease to her son with low alpha-galactosidase A activity.

  5. p.M187R GLA (show NAT8 Antibodies) mutation in Fabry disease causes a severe systemic and ophthalmologic phenotype, in both male and female patients.

  6. The results of the current study suggest that the GLA (show NAT8 Antibodies) haplotype D313Y does not lead to severe organ manifestations as seen in genotypes known to be causal for classical Fabry disease.

  7. Case Report: hypertrophic obstructive cardiomyopathy with Fabry disease with the GLA (show NAT8 Antibodies) E66Q mutation.

  8. We conclude that a mild GLA (show NAT8 Antibodies) variant is typically characterized by high residual enzyme activity and normal biomarker levels. We found evidence that these variants can still be classified as a distinctive, but milder, sub-type of FD.

  9. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA (show NAT8 Antibodies) gene that codes for alpha-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy.

  10. Study describes 5 novel mutations found in the GLA (show NAT8 Antibodies) gene of patients with clinical diagnosis of Fabry disease.

Mouse (Murine) Galactosidase, alpha (GLA) interaction partners

  1. Mice with alpha-galactosidase A deficiency show age-dependent and distinct deficits of the sensory system.

  2. In oocyte meiosis, GM130 (show GOLGA2 Antibodies) localization and expression patterns are regulated by FMNL1 (show FMNL1 Antibodies).

  3. The histological changes in Gla KO mice better resemble the type 2 later-onset phenotype observed in patients with residual alpha-galactosidase A activity.

  4. our findings imply that the alpha-GalA KO mouse is a good model in which to study the peripheral small fiber neuropathy exhibited by FD patients

  5. we demonstrate an age-dependent microvasculopathy of the mesenteric artery in a murine model of Fabry disease (galactosidase A-knockout mice) resulting from dysregulation of the vascular homeostatic enzyme endothelial nitric oxide synthase (eNOS (show NOS3 Antibodies))

  6. GM130 (show GOLGA2 Antibodies) regulates microtubule organization and might cooperate with the MAPK (show MAPK1 Antibodies) pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation

  7. It suggested that there could be a combination of GLA deficiency and FVL (show F5 Antibodies) or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.

  8. present Toll (show TLR4 Antibodies)-like receptor-dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for natural killer T cells

  9. Developed a novel recombinant lentiviral vector that engineers expression of alpha-galactosidase. Analysis of tissues at 26 wks demonstrated similar alpha-gal A enzyme activities but enhanced Gb3 reduction in hearts and kidneys compared with control.

  10. alpha-galactosidase A deficiency could be an important genetic modifier for the enhanced thrombosis associated with FV Leiden associated thrombosis.

GLA Antigen Profile

Protein Summary

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene names and symbols associated with GLA

  • galactosidase, alpha (GLA) antibody
  • galactosidase, alpha (gla) antibody
  • alpha-galactosidase (agaN) antibody
  • aga (aga) antibody
  • alpha-galactosidase (agaL) antibody
  • alpha-galactosidase (SCO0541) antibody
  • alpha-galactosidase (rafA) antibody
  • alpha-galactosidase (melA) antibody
  • Alpha-galactosidase (galA) antibody
  • alpha-galactosidase A (ANI_1_2528074) antibody
  • alpha-galactosidase A (ANI_1_1502124) antibody
  • alpha-galactosidase A (AOR_1_390174) antibody
  • alpha-galactosidase A (CpipJ_CPIJ002066) antibody
  • alpha-galactosidase (aga) antibody
  • alpha-galactosidase A (MCYG_00962) antibody
  • alpha-galactosidase A (MCYG_00791) antibody
  • alpha-galactosidase (gla) antibody
  • alpha-galactosidase A (Tsp_02909) antibody
  • alpha-galactosidase A (Tsp_02508) antibody
  • galactosidase, alpha (Gla) antibody
  • golgi autoantigen, golgin subfamily a, 2 (Golga2) antibody
  • Ags antibody
  • alpha-GAL antibody
  • AO090005000217 antibody
  • AW555139 antibody
  • GALA antibody
  • GM130 antibody
  • MGC130872 antibody
  • mKIAA4150 antibody
  • SCF11.21 antibody
  • SMU.877 antibody
  • zgc:101584 antibody

Protein level used designations for GLA

galactosidase, alpha , galactosidase alpha , Alpha-galactosidase A , alpha-D-galactosidase A , alpha-galactosidase A-like , alpha-galactosidase , Alpha-galactosidase , alpha-galactosidase A , agalsidase alfa , alpha-D-galactoside galactohydrolase 1 , alpha-gal A , melibiase , alpha-D-galactoside galactohydrolase , 130 kDa cis-Golgi matrix protein , Golgin subfamily A member 2 , SY11 protein , golgin-95

GENE ID SPECIES
280806 Bos taurus
465761 Pan troglodytes
703129 Macaca mulatta
734749 Xenopus laevis
100022779 Monodelphis domestica
100060370 Equus caballus
100145767 Xenopus (Silurana) tropicalis
100409841 Callithrix jacchus
100480888 Ailuropoda melanoleuca
100595113 Nomascus leucogenys
988766 Clostridium perfringens str. 13
1021683 Bifidobacterium longum NCC2705
1028243 Streptococcus mutans UA159
1095964 Streptomyces coelicolor A3(2)
1174420 Yersinia pestis CO92
1255824 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2956399 Yersinia pseudotuberculosis IP 32953
3977399 Lactobacillus salivarius UCC118
4983447 Aspergillus niger CBS 513.88
4987403 Aspergillus niger CBS 513.88
5989256 Aspergillus oryzae RIB40
6032795 Culex quinquefasciatus
7264928 Bifidobacterium animalis subsp. lactis AD011
9223595 Arthroderma otae CBS 113480
9226616 Arthroderma otae CBS 113480
9450395 Brachyspira pilosicoli 95/1000
10899858 Trichinella spiralis
10903123 Trichinella spiralis
2717 Homo sapiens
363494 Rattus norvegicus
450083 Danio rerio
422188 Gallus gallus
532742 Bos taurus
11605 Mus musculus
100344610 Oryctolagus cuniculus
100718405 Cavia porcellus
407057 Sus scrofa
480988 Canis lupus familiaris
99412 Mus musculus
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