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Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Additionally we are shipping and many more products for this protein.
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GBA2 is particularly abundant in Purkinje cells (PCs), one of the most affected neuronal populations in NPC (show NPC1 ELISA Kits) disease.
glucosylceramide accumulation in GBA2 knockout-mice alters cytoskeletal dynamics due to a more ordered lipid organization in the plasma membrane. Similar cytoskeletal defects were observed in male germ and Sertoli cells from GBA2 knockout-mice.
the deletion of Gba2 significantly rescues the type 1 Gaucher disease clinical phenotype.
redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butyldeoxygalactonojirimycin.
GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of glucosylceramide-dependent signaling.
The repression of IL-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signalling pathway seems to be one of the mechanisms for the delay of liver regeneration in GBA2-deficient mice.
GBA1 (show GBA ELISA Kits) and GBA2 activities had characteristic differences between the studied fibroblast, liver and brain samples.
The coiled-coil structure of LIMP-2 (show SCARB2 ELISA Kits) is required for its interaction with beta-glucocerebrosidase (show GBA ELISA Kits).
L-type calcium channel blockers have the ex vivo effects of increasing GCase (show GBA ELISA Kits) activity and protein in mouse fibroblasts
GBA2 is a glucosylceramidase (show GBA ELISA Kits) whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo.
, beta-glucocerebrosidase 2
, beta-glucosidase 2
, bile acid
, glucosidase, beta (bile acid) 2
, glucosylceramidase 2
, non-lysosomal glucosylceramidase
, bile acid beta-glucosidase