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Glutaminyl-Peptide Cyclotransferase Proteins (QPCT)

QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Antibodies (59) and QPCT Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
QPCT 25797 Q16769
Rat QPCT QPCT 83621  
QPCT 70536 Q9CYK2
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Top QPCT Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Crotalus atrox His tag   1 mg Log in to see 56 to 66 Days
$2,084.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,898.50
Details
Yeast Gloydius blomhoffii His tag   1 mg Log in to see 56 to 66 Days
$2,905.83
Details
Yeast Boiga irregularis His tag   1 mg Log in to see 56 to 66 Days
$2,937.00
Details
Yeast Boiga dendrophila His tag   1 mg Log in to see 56 to 66 Days
$2,937.00
Details

QPCT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced QPCT Proteins

  1. Human QPCT Protein expressed in Baculovirus infected Insect Cells - ABIN2005890 : Bateman, Temple, Misquitta, Booth: Evidence for essential histidines in human pituitary glutaminyl cyclase. in Biochemistry 2001 (PubMed)
    Show all 3 references for ABIN2005890

More Proteins for Glutaminyl-Peptide Cyclotransferase (QPCT) Interaction Partners

Human Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP Proteins) formation

  2. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.

  3. Upregulation of QPCT expression is associated with thyroid carcinomas.

  4. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP Proteins) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.

  5. Upon binding to PBD150, a large loop movement in gQC (show QPCTL Proteins) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.

  6. This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP Proteins) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.

  7. Human isoQC (show QPCTL Proteins)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  8. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.

  9. human glutaminyl cyclase is a metal-dependent transferase

  10. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively

Mouse (Murine) Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.

  2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH Proteins) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP Proteins) deposits

  3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL Proteins) in defined brain regions of different inbred and outbred mouse strains

  4. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism

  5. Murine isoQC (show QPCTL Proteins) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  6. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.

  7. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE Proteins), cathepsin B (show CTSB Proteins), and glutaminyl cyclase.

QPCT Protein Profile

Protein Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Gene names and symbols associated with QPCT

  • glutaminyl-peptide cyclotransferase (QPCT)
  • glutaminyl-peptide cyclotransferase (M6_Spy0443)
  • glutaminyl-peptide cyclotransferase (M5005_Spy_0416)
  • glutaminyl-peptide cyclotransferase (M28_Spy0404)
  • glutaminyl-peptide cyclotransferase (CJA_2408)
  • glutaminyl-peptide cyclotransferase (CCNA_02733)
  • glutaminyl-peptide cyclotransferase (Tsp_03182)
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (LOC100217805)
  • glutaminyl-peptide cyclotransferase (Qpct)
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct)
  • 5730422A13Rik protein
  • GCT protein
  • QC protein
  • QPCT protein
  • sQC protein

Protein level used designations for QPCT

glutaminyl-peptide cyclotransferase , glutaminyl-peptide cyclotransferase (glutaminyl cyclase) , EC , glutaminyl cyclase , glutaminyl-tRNA cyclotransferase , glutamyl cyclase , QC

GENE ID SPECIES
744549 Pan troglodytes
2942628 Streptococcus pyogenes MGAS10394
3572510 Streptococcus pyogenes MGAS5005
3574689 Streptococcus pyogenes MGAS6180
6415865 Cellvibrio japonicus Ueda107
7330894 Caulobacter crescentus NA1000
10908433 Trichinella spiralis
100217805 Taeniopygia guttata
421479 Gallus gallus
25797 Homo sapiens
403861 Canis lupus familiaris
397424 Sus scrofa
281437 Bos taurus
83621 Rattus norvegicus
70536 Mus musculus
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