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GRHL3 encodes a member of the grainyhead family of transcription factors. Additionally we are shipping GRHL3 Proteins (5) and many more products for this protein.
Showing 10 out of 43 products:
Human Polyclonal GRHL3 Primary Antibody for WB - ABIN2777797
Ting, Wilanowski, Cerruti, Zhao, Cunningham, Jane: The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. in The Biochemical journal 2003
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Human Polyclonal GRHL3 Primary Antibody for EIA, WB - ABIN952630
Guardiola-Serrano, Haendeler, Lukosz, Sturm, Melchner, Altschmied: Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. in Biochemical and biophysical research communications 2008
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Dog (Canine) Polyclonal GRHL3 Primary Antibody for IHC, WB - ABIN2781145
Darido, Georgy, Wilanowski, Dworkin, Auden, Zhao, Rank, Srivastava, Finlay, Papenfuss, Pandolfi, Pearson, Jane: Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. in Cancer cell 2011
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findings define a major role for Grhl3 in the induction of migration and invasion by the downregulation of E-cadherin (show CDH1 Antibodies) in cancer cells
We discovered a genome-wide significant association with a missense variant in GRHL3 and replicated the result in an independent sample of case and control subjects. In both samples, rs41268753 conferred increased risk for cleft palate.
We identified both rare dominant mutations and a common risk variant in the coding region of GRHL3 as causative in individuals with nonsyndromic cleft palate only.
GRHL1 (show GRHL1 Antibodies), GRHL2 (show GRHL2 Antibodies), and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
We defined a novel molecular signature in mammalian HNSCC, suggesting new treatment strategies targeting the GRHL3/GSK3B (show GSK3b Antibodies)/c-MYC (show MYC Antibodies) proto-oncogenic network.
our results indicate predominant GRHL3 expression in breast cancers
Our data demonstrated that mutations in two genes, IRF6 (show IRF6 Antibodies) and GRHL3, can lead to nearly identical phenotypes of orofacial cleft.
The splice variant-derived isoforms SOM1 and SOM3 induce opposing effects in primary human endothelial cells and in a whole animal model, most likely through the induction of different target genes.
decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR (show MLXIP Antibodies)-21 in squamous cell carcinoma of the skin.
In human keratinocytes, IRF6 (show IRF6 Antibodies) bound conserved elements near the GRHL3 promoter, with one of these elements having enhancer activity.
Upregulation of miR21 and repression of Grhl3 by leptin (show LEP Antibodies) mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.
This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia.
The developmental transcription factor Grhl3 is a potent tumor suppressor of squamous cell carcinoma in mice.
Both GRHL2 (show GRHL2 Antibodies) and GRHL3 bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Antibodies) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Antibodies)), is unique to GRHL3.
maps to Chromosome 4, 135 Mb (66 cM) from the centromere, probably not Idb3 (show ID3 Antibodies), Wnt4 (show WNT4 Antibodies), Cdc42 (show CDC42 Antibodies), perlecan (show HSPG2 Antibodies) or Grhl-3
Loss of Grhl3 alone defines a distinct lower spinal closure defect, also with defective dorso-lateral hinge points formation
folate deficiency caused a similar-sized, statistically significant increase in the frequency of exencephaly among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3.
formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3[Grhl3]
Unique role of Grhl3 in neurulation and epidermal morphogenesis.
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
grainyhead-like 3 (Drosophila)
, sister-of-mammalian grainyhead protein
, grainyhead-like protein 3 homolog
, sister of mammalian grainyhead
, sister-of-mammalian grainyhead
, transcription factor CP2-like 4
, transcription factor hSOM1
, grainy head-like 3