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GCA product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. Additionally we are shipping Grancalcin Proteins (17) and Grancalcin Kits (2) and many more products for this protein.
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Homozygous Gca (show GUCA1A Antibodies) mutants appeared healthy and reproduced normally. Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin.
findings suggest that grancalcin plays a key role in leukocyte-specific functions that are responsible for host defense
Adhesion to fibronectin (show FN1 Antibodies) of grancalcin-deficient neutrophils was decreased by 60% compared to control cells.
Results indicate that heterodimerization of GCA (show NPR1 Antibodies) and TLR9 (show TLR9 Antibodies) is important for TLR9 (show TLR9 Antibodies)-mediated downstream signaling and might serve to fine tune processes against viral infection.
GCA (show NPR1 Antibodies) interacts with SRI (show SRI Antibodies) in vivo and in vitro.
The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, FAP, IFIH1 (show IFIH1 Antibodies) and GCA (show NPR1 Antibodies).
IFIH1 (show IFIH1 Antibodies) interferon (show IFNA Antibodies) induced helicase, GCA grancalcin or the potassium channel (show KCNAB2 Antibodies) KCNH7 (show KCNH7 Antibodies) - are potential candidates implicated in the pathogenesis of multiple sclerosis.
IFIH1 (show IFIH1 Antibodies)-GCA (show NPR1 Antibodies)-KCNH7 (show KCNH7 Antibodies) locus is not associated with genetic susceptibility to multiple sclerosis in French patients
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction\; with magnesium alone, it partitions with the granule fraction\; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
, grancalcin, EF-hand calcium-binding protein
, grancalcin, penta-EF-hand protein