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anti-Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) Antibodies

The protein encoded by GZMH is a member of the granzyme family. Additionally we are shipping Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Kits (5) and Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GZMH 2999 P20718
GZMH 617313  
GZMH    
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Top anti-Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-GZMH Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-GZMH  Antibody Titration: 2.5 µg/mL  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry (IHC) analyzes of Granzyme H antibody in paraffin-embedded human pancreas tissue. Western blot (WB) analysis of Granzyme H antibody in extracts from K562 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Granzyme H staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Granzyme H staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Mouse Un-conjugated ELISA   100 μg Log in to see 16 Days
$218.90
Details
Human Mouse Un-conjugated WB Western Blot analysis of GZMH expression in transfected 293T cell line by GZMH MaxPab polyclonal antibody.Lane 1: GZMH transfected lysate(27.06 KDa).Lane 2: Non-transfected lysate. GZMH MaxPab polyclonal antibody. Western Blot analysis of GZMH expression in human spleen. 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB   100 μL Log in to see 14 Days
$201.19
Details

GZMH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
,
,
Cow (Bovine)


Mouse (Murine)


Top referenced anti-Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Antibodies

  1. Cow (Bovine) Polyclonal GZMH Primary Antibody for IHC, WB - ABIN2775539 : Sedelies, Sayers, Edwards, Chen, Pellicci, Godfrey, Trapani: Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Interaction Partners

Human Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) interaction partners

  1. Granzyme H did directly process DFF45 (show DFFA Antibodies), potentially leading to DNA damage.

  2. Upon reactive center loop cleavage at Phe-343,SERPINB1 (show SERPINB1 Antibodies) covalently complexes with GzmH. SERPINB1 (show SERPINB1 Antibodies) overexpression suppresses GzmH- or LAK (show ARL4C Antibodies) cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition.

  3. An unusual RKR (show CACNA1A Antibodies) motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites.

  4. GzmH suppresses viral replication through association with the hepatitis B virus x protein.

  5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B (show Gzmb Antibodies) to cause classical apoptosis.

  6. granzyme H complements the pro-apoptotic function of granzyme B (show Gzmb Antibodies) in human NK cells

  7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B (show Gzmb Antibodies) inhibition.

  8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity.

  9. GzmH may play an essential role in caspase (show CASP3 Antibodies)-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB (show Gzmb Antibodies) in human NK cells.

  10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B (show Gzmb Antibodies).

Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with GZMH

  • granzyme H (cathepsin G-like 2, protein h-CCPX) (GZMH) antibody
  • granzyme H (GZMH) antibody
  • CCP-X antibody
  • CGL-2 antibody
  • CSP-C antibody
  • CTLA1 antibody
  • CTSGL2 antibody
  • GZMH antibody

Protein level used designations for GZMH

granzyme H , cytotoxic T-lymphocyte proteinase , cytotoxic T-lymphocyte-associated serine esterase 1 , cytotoxin serine protease-C

GENE ID SPECIES
617313 Bos taurus
100113476 Felis catus
2999 Homo sapiens
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