Growth Factor, Augmenter of Liver Regeneration Proteins (GFER)

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. Additionally we are shipping GFER Antibodies (68) and GFER Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GFER 2671 P55789
Rat GFER GFER 27100 Q63042
GFER 11692 P56213
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Top GFER Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_HEK-293 Cells Human Un-conjugated 50 μg Log in to see 21 to 31 Days
$605.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Un-conjugated 10 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$329.18
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$212.50
Details
HOST_HEK-293 Cells Human Un-conjugated   20 μg Log in to see 2 to 3 Days
$515.63
Details

GFER Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,
,

Top referenced GFER Proteins

  1. Human GFER Protein expressed in HEK-293 Cells - ABIN2181149 : Daithankar, Farrell, Thorpe: Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space. in Biochemistry 2009 (PubMed)
    Show all 3 references for 2181149

  2. Human GFER Protein expressed in Escherichia coli (E. coli) - ABIN1098493 : Farrell, Thorpe: Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity. in Biochemistry 2005 (PubMed)
    Show all 2 references for 1098493

  3. Human GFER Protein expressed in Wheat germ - ABIN1355011 : Kondo, Yamato, Takagi, Namiki, Okano: The regulation of epithelial cell proliferation and growth by IL-1 receptor antagonist. in Biomaterials 2012 (PubMed)

More Proteins for Growth Factor, Augmenter of Liver Regeneration (GFER) Interaction Partners

Human Growth Factor, Augmenter of Liver Regeneration (GFER) interaction partners

  1. Our results show that MARK4 (show MARK4 Proteins) acts as a negative regulator of the Hippo kinase cassette to promote YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activity and that loss of MARK4 (show MARK4 Proteins) restrains the tumorigenic properties of breast cancer cells.

  2. ALR, dependent on its localization, changes the acute-phase response (APR (show LRP1 Proteins)) at least in part, by modifying STAT3 (show STAT3 Proteins) activation; dual signaling of ALR suggests that ALR is pivotal for the regulation of APR (show LRP1 Proteins), a crucial event in liver injury and regeneration

  3. the mechanistic regulation and linkage of the ROR1 (show ROR1 Proteins)-HER3 (show ERBB3 Proteins) and Hippo-YAP (show YAP1 Proteins) pathway in a cancer-specific context

  4. S100A7 (show S100A7 Proteins) induction by the Hippo-YAP (show YAP1 Proteins) pathway in cervical and glossopharyngeal squamous cell carcinoma has been described.

  5. FAT1 protein acts upstream of Hippo signalling through TAZ (show TAZ Proteins) protein to regulate neuronal differentiation.

  6. ALR protects cells from apoptosis partly through increased autophagy in HepG2 cells.

  7. Knockdown of GFER exerts anti-inflammatory actions via suppression of the mitogen-activated protein kinase (show MAPK1 Proteins) signaling pathway

  8. ALR plays a protective role against hydrogen peroxide-induced oxidative stress in renal proximal tubule cells.

  9. Data show that the over-expression of 23 kDa augmenter of liver regeneration (ALR) in hepatic cell line LO2 cells promoted the cell proliferation and enhanced cell resistance to hydrogen peroxide.

  10. Upregulation of miR (show MLXIP Proteins)-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway.

Mouse (Murine) Growth Factor, Augmenter of Liver Regeneration (GFER) interaction partners

  1. The exogenous expression of hepatic stimulator substance (HSS (show PANK2 Proteins) was renamed augmenter of liver regeneration ALR) protected the liver from steatosis in mice with nonalcoholic steatohepatitis.

  2. this study shows that ALR can weaken ConA-induced hepatitis

  3. ALR is apparently required to ensure appropriate liver regeneration following PH in mice, and deletion of the ALR gene may delay liver regeneration in part due to impaired mitochondrial biogenesis.

  4. ALR can protect mice against acute liver injury by up-regulating the expression of regulatory T cells.

  5. From weeks 2-4 after birth, levels of steatosis and apoptosis decreased in ALR-L-KO mice, and numbers of ALR-expressing cells increased, along with ATP level

  6. As a mechanism, we suggest a direct protective effect of ALR on apoptotic and necrotic death of hepatocytes and an attenuation of inflammatory cell influx into the postischemic tissue.

  7. ALR may serve as a potential diagnostic marker of hepatocellular stress and/or acute inflammatory conditions.

  8. Growth factor erv1-like (Gfer) inhibits the COP9 (show COPS8 Proteins) signalosome subunit jun activation-domain binding protein 1 (Jab1 (show COPS5 Proteins))-mediated degradation of the cyclin-dependent kinase inhibitor p27(kip1 (show CDKN1B Proteins)) to restrict proliferation of hematopoietic stem cells.

  9. Gfer plays an essential pro-survival role in the maintenance of murine embryonic stem cell pluripotency by preserving the structural and functional integrity of their mitochondria, through modulation of the key mitochondrial fission factor Drp1.

  10. Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells

GFER Protein Profile

Protein Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.

Gene names and symbols associated with GFER

  • growth factor, augmenter of liver regeneration (GFER)
  • growth factor, augmenter of liver regeneration (gfer)
  • growth factor, augmenter of liver regeneration (Gfer)
  • growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) (Gfer)
  • Alr protein
  • ERV1 protein
  • HERV1 protein
  • HPO protein
  • HPO1 protein
  • HPO2 protein
  • HSS protein

Protein level used designations for GFER

growth factor, augmenter of liver regeneration , growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) , FAD-linked sulfhydryl oxidase ALR , ERV1 homolog , erv1-like growth factor , hepatic regenerative stimulation substance , hepatopoietin protein , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration)

GENE ID SPECIES
479885 Canis lupus familiaris
618423 Bos taurus
694203 Macaca mulatta
733269 Xenopus laevis
750034 Pan troglodytes
2671 Homo sapiens
27100 Rattus norvegicus
11692 Mus musculus
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