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Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O Proteins (GNAO1)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Additionally we are shipping GNAO1 Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNAO1 2775 P09471
GNAO1 50664 P59215
GNAO1 14681 P18872
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Top GNAO1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast REACT_Migratory locust His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast REACT_Great Pond Snail His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
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Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast Cricetulus longicaudatus His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details

GNAO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

Mouse (Murine) ,

More Proteins for Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Interaction Partners

Human Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) interaction partners

  1. authors report 2 cases of brothers with a severe movement disorder and hypotonia without epilepsy who have been confirmed by whole exome sequencing to have a novel mutation in GNAO1

  2. Phenotypic spectrum of novel GNAO1 variants in four unrelated female patients included epileptic encephalopathy and involuntary movements with severe developmental delay.

  3. GNAO1 is a disease-causing gene for the autosomal dominant form of early infantile epileptic encephalopathy. The novel pathogenic variant identified in should contribute to our understanding of the expanding spectrum of infantile-onset epilepsy.

  4. Endothelial cells in capillary malformations are enriched for GNAQ mutations and are likely responsible for the pathophysiology underlying capillary malformation.

  5. Galphao-R243H has a mild decrease in nucleotide affinity that causes rapid nucleotide turnover and subsequent hyperactivity in cancer

  6. Genetic variants of BCL2, GNAO1, and CHD2 are associated with non-obstructive azoospermia risk.

  7. the present study is the first to demonstrate that GNAO1 is overexpressed in GC and that its overexpression correlates with poor prognosis, as it promotes gastric cancer cell viability.

  8. Down-regulation of GNAO1 increases cell proliferation, while suppressing the senescence of hepatocellular carcinoma cells.

  9. These data suggest that aberrant Galphao signaling can cause multiple neurodevelopmental phenotypes, including epileptic encephalopathy and involuntary movements.

  10. Data show that HEK293T cells transfected with estrogen receptor alpha (ERalpha (show ESR1 Proteins))+/-Galpha(o) revealed that Galpha(o) stimulated phosphorylation of ERK (show EPHB2 Proteins) MAP kinases ERK 1 (show MAPK3 Proteins)/2 and subsequently increased the phosphorylation of ERalpha (show ESR1 Proteins) on serine 118.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) interaction partners

  1. These results indicated the interaction of GAP-43 (show GAP43 Proteins) and Galpha(o) could accelerate conversion of depalmitoylated Galpha(o) but not palmitoylated Galpha(o) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o).

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) interaction partners

  1. stimulation of GPR17 (show GPR17 Proteins) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (show MBP Proteins) expression levels mainly by triggering the Galphai/o signaling pathway.

  2. Necdin (show NDN Proteins) is a candidate downstream effector for Galphao.

  3. This heterozygous Gnao1 +/G184S mutation produces early neonatal and adult lethality accompanied by epileptiform discharges.

  4. These results highlight that sensory neurons of the Galphao-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice.

  5. Data indicate that rectifying potassium channel (show KCNAB2 Proteins) Kir2.4 (show KCNJ14 Proteins) interacts with G-protein subunit Galphao.

  6. Data show that Galphao is an essential requirement for the display of male-male territorial aggression as well as maternal aggression.

  7. Data suggest that the novel R234H mutation imparts oncogenic properties to Galphao by accelerating nucleotide exchange and rendering it constitutively active.

  8. The 2.9 A crystal structure of the enigmatic, neuronal G protein Galpha(o) in the GTP (show AK3 Proteins) hydrolytic transition state, complexed with RGS16 (show RGS16 Proteins).

  9. Go alpha subunit (show POLG Proteins) mainly appears to be bound to the cell membrane and concentrated in the thin finger-like dendrites of rod bipolar cells, as well as in green fluorescent protein-positive cone bipolar cells.

  10. Binding of activated Galphao to GRIN1 (show GRIN1 Proteins) induces activation of Cdc42 (show CDC42 Proteins), which leads to morphological changes in neuronal cells.

Caenorhabditis elegans (C. elegans) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) interaction partners

  1. Following food deprivation G protein alpha(o) is activated via RIC-8 (show RIC8A Proteins) activation.

  2. findings show that the GoLoco-containing proteins GPR-1 and GPR-2, as well as the Galpha subunits GOA-1 and GPA-16, were essential for generation of proper pulling forces in asymmetric spindle positioning

  3. Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES (show MKS1 Proteins)-1/SRC-1 (show NCOA1 Proteins) signaling pathway.

  4. Our results suggest that EGL-47 regulates egg laying by activating Galpha(o) in the hermaphrodite-specific motor neurons to inhibit their activity.

  5. down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis

  6. The stravation response is fully dependent on the subsequent activation of the G alpha(q) ortholog EGL-30.

  7. These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction.

  8. Serotonin signaling is regulated by modulating serotonin biosynthesis and Galphao and Galphaq (show GNAQ Proteins) act in the same neurons to have opposing effects on behavior, in part, by antagonistically regulating transcription of specific genes.

  9. Goa-1 Goalpha and let-60 Ras act in parallel to gpc-1 in olfactory pathways.

GNAO1 Protein Profile

Protein Summary

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

Gene names and symbols associated with GNAO1

  • G protein alpha subunit (gna0)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (Gnao1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (gnao1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a (gnao1a)
  • guanine nucleotide binding protein, alpha O (Gnao1)
  • Protein GOA-1 (goa-1)
  • alphaO protein
  • AW050213 protein
  • G-ALPHA-o protein
  • Galphao protein
  • Gnao protein
  • gnao1 protein
  • gnao1-A protein
  • RATBPGTPC protein
  • wu:fq26h05 protein
  • XGalpha01 protein
  • zgc:73315 protein

Protein level used designations for GNAO1

guanine nucleotide-binding protein G(o) subunit alpha , GTP-binding protein alpha o , guanine nucleotide binding protein, alpha O polypeptide 1 , GTP-binding protein G39 , Galpha o1 , GTP-binding protein alpha-o subunit , Go alpha

GENE ID SPECIES
397896 Xenopus laevis
2775 Homo sapiens
50664 Rattus norvegicus
394423 Xenopus laevis
415698 Gallus gallus
609157 Canis lupus familiaris
281792 Bos taurus
100716648 Cavia porcellus
393760 Danio rerio
14681 Mus musculus
172505 Caenorhabditis elegans
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