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HUS1 Checkpoint Homolog (S. Pombe) Proteins (HUS1)

The protein encoded by HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. Additionally we are shipping HUS1 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat HUS1 HUS1 498411  
HUS1 3364 O60921
HUS1 15574 Q8BQY8
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Top HUS1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,755.50
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HUS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced HUS1 Proteins

  1. Human HUS1 Protein expressed in Escherichia coli (E. coli) - ABIN667288 : Roos-Mattjus, Vroman, Burtelow, Rauen, Eapen, Karnitz: Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667288

More Proteins for HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaction Partners

Human HUS1 Checkpoint Homolog (S. Pombe) (HUS1) interaction partners

  1. These results suggest that p21(Waf1/CIP1 (show CDKN1A Proteins)) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose alpha-particle irradiation.

  2. adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH (show MUTYH Proteins) and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA (show PCNA Proteins); only Q324H was found to have reduced affinity for Hus1

  3. Intramolecular binding of the rad9 (show RAD9A Proteins) C-terminus in the checkpoint clamp (show PDZK1 Proteins) Rad9 (show RAD9A Proteins)-Hus1-Rad1 is closely linked with its DNA binding.

  4. these pockets were not required for 9-1-1 chromatin localization or ATR (show ANTXR1 Proteins)-mediated CHK1 (show CHEK1 Proteins) activation but were necessary for interactions between HUS1 and its binding partner MYH (show MUTYH Proteins)

  5. Expression of cell cycle regulatory factors hus1, gadd45a (show GADD45A Proteins), rb1 (show RB1 Proteins), cdkn2a and mre11a (show MRE11A Proteins) correlates with expression of clock gene per2 (show PER2 Proteins) in human colorectal carcinoma tissue.

  6. HUS1 polymorphisms act as risk breast cancer modifiers in the group of non-carriers of BRCA1/2 mutations.

  7. Data show models for the ternary PCNA (show PCNA Proteins)/FEN1 (show FEN1 Proteins)/DNA and Rad9 (show RAD9A Proteins)-Rad1-Hus1 (9-1-1 complex)/FEN1 (show FEN1 Proteins)/DNA assemblies.

  8. The HUS1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.

  9. The HUS1 protein interacts with casein kinase 2.

  10. Rad9 (show RAD9A Proteins)-Rad1-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase (show OGG1 Proteins).

Mouse (Murine) HUS1 Checkpoint Homolog (S. Pombe) (HUS1) interaction partners

  1. Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity.

  2. Disease severity in a mouse model of ataxia (show USP14 Proteins) telangiectasia is modulated by the DNA damage checkpoint gene Hus1

  3. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (show RAD1 Proteins) and TOPBP1 (show TOPBP1 Proteins) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 (show RAD9A Proteins) or HUS1.

  4. requirement for Hus1 in the survival and proliferation of mammary epithelium

  5. Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase.

  6. Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin or ionizing radiation

  7. we show a requirement for Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation of nuclear foci containing H2AX and breast cancer susceptibility protein 1

  8. results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of nonhomologous end-joining but might be linked to homologous recombination repair

  9. Hus1 loss leads to chromosomal instability during DNA replication, triggering increased apoptosis and impaired proliferation through p53 (show TP53 Proteins)-independent mechanisms.

  10. identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis

HUS1 Protein Profile

Protein Summary

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with HUS1

  • HUS1 checkpoint homolog (S. pombe) (Hus1)
  • HUS1 checkpoint homolog (S. pombe) (HUS1)
  • Hus1 homolog (S. pombe) (Hus1)
  • hHUS1 protein
  • mHus1 protein

Protein level used designations for HUS1

Hus1 homolog , checkpoint protein HUS1 , hus1+-like protein

GENE ID SPECIES
498411 Rattus norvegicus
3364 Homo sapiens
15574 Mus musculus
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