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HUS1 Products

(HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

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The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].

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Featured HUS1 Categories

HUS1 Antibodies

High quality antibodies with extensive validation data.

HUS1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HUS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (5)
Cat. No. ABIN2856928
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, IP, WB
Validations
  • (4)
Cat. No. ABIN6142085
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (4)
Cat. No. ABIN7257499
Quantity 200 μL
Datasheet Datasheet

Recommended HUS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6228854
Quantity 96 tests
Datasheet Datasheet

Recommended HUS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093027
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3125157
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709689
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our HUS1 products

Hirai, Sasaki, Wang: "Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation." in: Oncogene, Vol. 23, Issue 30, pp. 5124-30, (2004) (PubMed).

Toueille, El-Andaloussi, Frouin, Freire, Funk, Shevelev, Friedrich-Heineken, Villani, Hottiger, Hübscher: "The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair." in: Nucleic acids research, Vol. 32, Issue 11, pp. 3316-24, (2004) (PubMed).

Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).

Synonyms and alternative names related to HUS1

HUS1 checkpoint clamp component (HUS1), HUS1 checkpoint clamp component (Hus1), checkpoint clamp complex protein Hus1 (hus1), HUS1 checkpoint clamp component L homeolog (hus1.L), hHUS1, hus1, mHus1, XHus1

Protein level used designations for HUS1

  • checkpoint protein HUS1
  • hus1+-like protein
  • Hus1 homolog
  • HUS1 checkpoint homolog
  • HUS1 checkpoint protein
  • HUS1 checkpoint clamp component L homeolog
  • PCNA-like DNA checkpoint protein Hus1
  • checkpoint protein Hus1
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