HUS1 Products
(HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
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The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].
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Featured HUS1 Categories
HUS1 Antibodies
High quality antibodies with extensive validation data.
HUS1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HUS1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN2856928
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6142084
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (4)
Cat. No.
ABIN7257499
Quantity
200 μL
Datasheet
Datasheet
Recommended HUS1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228854
Quantity
96 tests
Datasheet
Datasheet
Recommended HUS1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123371
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307294
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3093027
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our HUS1 products
: "Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation." in: Oncogene, Vol. 23, Issue 30, pp. 5124-30, (2004) (PubMed).: "The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair." in: Nucleic acids research, Vol. 32, Issue 11, pp. 3316-24, (2004) (PubMed).
: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).
Synonyms and alternative names related to HUS1
HUS1 checkpoint clamp component (HUS1), HUS1 checkpoint clamp component (Hus1), checkpoint clamp complex protein Hus1 (hus1), HUS1 checkpoint clamp component L homeolog (hus1.L), hHUS1, hus1, mHus1, XHus1Protein level used designations for HUS1
- checkpoint protein HUS1
- hus1+-like protein
- Hus1 homolog
- HUS1 checkpoint homolog
- HUS1 checkpoint protein
- HUS1 checkpoint clamp component L homeolog
- PCNA-like DNA checkpoint protein Hus1
- checkpoint protein Hus1
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