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The protein encoded by HAVCR1 is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. Additionally we are shipping HAVCR1 Antibodies (147) and HAVCR1 Kits (70) and many more products for this protein.
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Human HAVCR1 Protein expressed in Human Cells - ABIN2003797
Gandhi, Yi, Ha, Shi, Ismail, Nathoo, Bonventre, Zhang, Gunaratnam: Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis. in American journal of physiology. Renal physiology 2014
Data suggest that T-cell immunoglobulin domain and mucin domain containing protein 1 (TIM1) to be under positive natural selection in primates.
Urinary L-FABP (show FABP1 Proteins), NGAL (show LCN2 Proteins), Kim-1 and albumin (show ALB Proteins) levels increased during the acute phase of kidney injury and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. These markers could detect higher risk of progression to CKD.
Blockade of Tim-1 changes Th1 (show HAND1 Proteins)/Th2 balance and reduces circulating regulatory T cells to enhance atherosclerosis in LDL receptor (show LDLR Proteins) knockout mice.
Our results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury
data suggest that TIM-1 signaling plays a direct role in Breg maintenance and induction both under physiological conditions (in response to ACs (show Acsl1 Proteins)) and in response to therapy through TIM-1 ligation
Deletion of the mucin (show SLC13A2 Proteins) domain impaired KIM-1-mediated phagocytic function, resulting in increased proinflammatory cytokine production, decreased antiinflammatory growth factor secretion by proximal epithelial cells, and an increase in tissue macrophages.
Tim-1 is critical for maintaining self-tolerance by regulating IL-10 (show IL10 Proteins) production in Bregs
Tim-1 expression was lower in a herpes simplex virus-induced Behcet's disease (BD) mouse model compared to that in asymptomatic BD normal (BDN) mice.
Tim-1-Fc protects cardiac grafts from chronic rejection by suppressing CD4 (show CD4 Proteins) Th17 development and functionality.
KIM-1 shedding is accelerated by worsening renal cellular injury, and excess soluble KIM-1 competitively inhibits efferocytosis.
Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr (show FAS Proteins)) mice.
preliminary data indicates that KIM-1 expression may be associated with stage in Wilms Tumor
Urinary KIM-1 and NAG levels were positively correlated.
TLR2, Tim1 (show ARHGEF5 Proteins), Tim3 (show HAVCR2 Proteins), TNF-alpha (show TNF Proteins), IgE and EOS (show IKZF4 Proteins) play a role in Mycoplasma pneumoniae Pneumonia-related wheezing in children.
The results of our study showed that there is no significant association between TIM-1 (show ARHGEF5 Proteins) 5383-5397ins/del and Multiple sclerosis (MS) (P = 0.38); however, the frequency of CT genotype of TIM-3 (show HAVCR2 Proteins) -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS
Study emphasizes a strong association of the tubular biomarker KIM-1 with chronic kidney disease progression in chronic heart failure and suggests usefulness as cardiorenal marker.
Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 and FGF-21 (show FGF21 Proteins) concentration increase in the blood serum.
KIM-1 expression also enhances ERK MAPK (show MAPK1 Proteins) activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK (show MAPK1 Proteins) signaling pathway.
KIM-1 may mediate high glucose-induced autophagy and apoptosis in renal tubular epithelial cells.
Study suggests that TIM1 -416G>C and -1454G>A single nucleotide polymorphisms are associated with dilated cardiomyopathy susceptibility and prognosis in this Han Chinese population.
elevated baseline plasma KIM-1 strongly associated with risk of early progressive renal decline in type 1 diabetes
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene.
hepatitis A virus cellular receptor 1
, T-cell immunoglobulin and mucin domain containing 1
, hepatitis A virus cellular receptor 1 homolog
, kidney injury molecule 1
, t cell immunoglobulin and mucin domain-containing protein 1
, t cell membrane protein 1
, T cell immunoglobin domain and mucin domain protein 1
, T-cell membrane protein 1
, rho guanine nucleotide exchange factor 5