HAVCR1 Protein (AA 23-342) (His tag)

Catalog No. ABIN7454163

Product Details

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Protein Type: Recombinant

Protein Characteristics: AA 23-342

Origin: Cynomolgus

Source: HEK-293 Cells

Purification tag / Conjugate: This HAVCR1 protein is labelled with His tag.

Purpose: Cynomolgus TIM-1/HAVCR1 Protein

Sequence: Val23-Gly342

Characteristics: Recombinant Cynomolgus TIM-1/HAVCR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val23-Gly342.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Alternative Name: TIM-1 (HAVCR1 Products)

Synonyms: HAVCR Protein, HAVCR-1 Protein, KIM-1 Protein, KIM1 Protein, TIM Protein, TIM-1 Protein, TIM1 Protein, TIMD-1 Protein, TIMD1 Protein, Kim1 Protein, HAVCR1 Protein, LOC100226241 Protein, AI503787 Protein, Tim1 Protein, Timd1 Protein, hepatitis A virus cellular receptor 1 Protein, hepatitis A virus cellular receptor 1 homolog Protein, HAVCR1 Protein, Havcr1 Protein, LOC100226241 Protein

Background: Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.

Molecular Weight: 35.25 kDa. Due to glycosylation, the protein migrates to 100-150 kDa based on Tris-Bis PAGE result.

UniProt: A0A2K5WXJ6