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anti-Hexosaminidase B (Beta Polypeptide) (HEXB) Antibodies

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Additionally we are shipping HEXB Kits (20) and HEXB Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HEXB 15212 P20060
HEXB 294673 Q6AXR4
HEXB 3074 P07686
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Top anti-HEXB Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from Jurkat cells using HEXB Antibody . The lane on the right is treated with the synthesized peptide. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- HEXB antibody,IHC(P) IHC(P): Human Lung Cancer Tissue Anti- HEXB antibody, Western blotting All lanes: Anti HEXB  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: HEPG2 Whole Cell Lysate at 40ug Predicted bind size: 63KD Observed bind size: 63KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using HEXB Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using HEXB Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of HEXB staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of HEXB staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$347.60
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details

HEXB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,


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Rat (Rattus) ,



Human , , , ,
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Top referenced anti-HEXB Antibodies

  1. Human Polyclonal HEXB Primary Antibody for EIA, IHC (p) - ABIN1449678 : Korneluk, Mahuran, Neote, Klavins, ODowd, Tropak, Willard, Anderson, Lowden, Gravel: Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease. in The Journal of biological chemistry 1986 (PubMed)
    Show all 3 references for ABIN1449678

More Antibodies against HEXB Interaction Partners

Mouse (Murine) Hexosaminidase B (Beta Polypeptide) (HEXB) interaction partners

  1. mast cell granule beta-hexosaminidase (show HEXA Antibodies) is crucial for defense against bacterial invasion, but is not involved in the allergic response. the bactericidal mechanism of beta-hexosaminidase (show HEXA Antibodies) involves degradation of bacterial cell wall peptidoglycan.

  2. transgenic inducible strains of Sandhoff disease mice provide a dynamic platform with which to explore the pathophysiological sequelae immediately after loss of neuronal lysosomal beta-hexosaminidase (show HEXA Antibodies) activity.

  3. Data suggest that pathogenesis of Sandhoff disease (heritable beta-hexosaminidase (show HEXA Antibodies) deficiency) involves an increase in macrophage-inflammatory protein 1alpha (show CCL3 Antibodies) that induces monocytes to infiltrate the CNS and trigger neuronal apoptosis.

  4. The bicistronic beta-hexosaminidase (show HEXA Antibodies) vector can reverse the biochemical defects and down-stream consequences in Sandhoff neurons, reinforcing its potential for Sandhoff disease in vivo gene therapy.

  5. Beta-hexosaminidase (show HEXA Antibodies) is a peptidoglycan hydrolase that surprisingly exerts its mycobactericidal effect at the macrophage plasma membrane during mycobacteria-induced secretion of lysosomes

  6. There was no change in the level of GM2 (show CYB5D2 Antibodies) storage and pro-apoptotic activity or astrocyte activation in HexB-/- knockout mice

  7. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Hexosaminidase B (Beta Polypeptide) (HEXB) interaction partners

  1. The absence of beta-N-acetyl-hexosaminidase activity does not alter the differentiation of i-DCs from HSCs, but it is critical for the activation of CD4 (show CD4 Antibodies)(+)T cells because knock-down of HEXA (show HEXA Antibodies) or HEXB gene causes a loss of function of i-DCs.

  2. A total of 19 HEXB variants were found in the 1092 genomes of which 5 are suspected of having a deleterious effect on hexosaminidase activity.

  3. DNA from Iranian Tay-Sachs patients reveals a novel mutation in HEXB predicting a termination codon or nonsense mutation.

  4. A patient with Sandhoff disease also is found to have a compound macro-deletion in HEXB.

  5. GM2 (show CYB5D2 Antibodies) gangliosidosis is caused by the gene mutation. (review)

  6. A highly significant correlation of HEX (show HHEX Antibodies)-7 and %CDT has been found. Because of exclusion of the P isoform, HEX (show HHEX Antibodies)-7 could be a useful supplementary marker for detecting chronic alcohol abuse.

  7. Expression of beta-hexosaminidase (show HEXA Antibodies) in the neurons of Sandhoff disease patients rescues transgenic mice from neurodegeneration.

  8. minigene studies revealed the presence of a novel alternative spliced HEXB mRNA variant also present in normal cells

  9. Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.

  10. identified 27 different mutations, 14 of which were novel, in the HEXA (show HEXA Antibodies) gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients

HEXB Antigen Profile

Protein Summary

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).

Gene names and symbols associated with HEXB

  • hexosaminidase B (Hexb) antibody
  • hexosaminidase B (beta polypeptide) (HEXB) antibody
  • ENC-1AS antibody

Protein level used designations for HEXB

N-acetyl-beta-glucosaminidase subunit beta , beta-N-acetylhexosaminidase subunit beta , beta-hexosaminidase subunit beta , hexosaminidase subunit B , HCC-7 , cervical cancer proto-oncogene 7 protein , beta-N-acetylhexosaminidase beta subunit , beta-hexosaminidase beta subunit , 65 kDa epididymal boar protein

GENE ID SPECIES
15212 Mus musculus
294673 Rattus norvegicus
3074 Homo sapiens
493928 Felis catus
396958 Sus scrofa
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