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anti-Hyaluronan Synthase 1 (HAS1) Antibodies

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. Additionally we are shipping HAS1 Kits (8) and HAS1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HAS1 282821  
HAS1 3036 Q92839
HAS1 15116 Q61647
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Top anti-HAS1 Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of HAS1 Antibody (Center) (ABIN651121) in ZR-75-1 cell line lysates (35 µg/lane). HAS1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Immunofluorescence analysis of U251 cells using HAS1 mAb (green) . Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Figure 2: Western blot analysis using HAS1 mAb against human HAS1 (AA: 74-243) recombinant protein. (Expected MW is 44.4 kDa) 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat spleen labeled with Anti-HAS1 Polyclonal Antibody, Unconjugated (ABIN682093) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$418.00
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

HAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HAS1 Antibodies

  1. Human Polyclonal HAS1 Primary Antibody for WB - ABIN651121 : Vigetti, Genasetti, Karousou, Viola, Clerici, Bartolini, Moretto, De Luca, Hascall, Passi: Modulation of hyaluronan synthase activity in cellular membrane fractions. in The Journal of biological chemistry 2009 (PubMed)
    Show all 4 references for ABIN651121

  2. Human Monoclonal HAS1 Primary Antibody for EIA, IF - ABIN1107624 : Adamia, Treon, Reiman, Tournilhac, McQuarrie, Mant, Belch, Pilarski: Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. in Clinical lymphoma 2005 (PubMed)
    Show all 2 references for ABIN1107624

  3. Human Monoclonal HAS1 Primary Antibody for ICC, ELISA - ABIN969185 : Stuhlmeier: Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969185

More Antibodies against HAS1 Interaction Partners

Human Hyaluronan Synthase 1 (HAS1) interaction partners

  1. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199 (show KIAA1199 Antibodies)) and HA Synthases in Growth Factor-stimulated Fibroblasts.

  2. The minor allele genotypes of HAS1 SNPs are significantly more frequent in MM, WM, CLL and in affected members of a monoclonal gammopathy-prone family than they are in breast cancer, sporadic MGUS or healthy donors

  3. transcriptional regulation of the HAS and HAS2 (show HAS2 Antibodies)-antisense RNA 1 genes, was analyzed.

  4. HAS1 is the main enzyme responsible for hyaluronan production by normal keratinocytes.

  5. The HAS1-dependent coat is induced by inflammatory agents and glycemic stress, mediated by altered presentation of either CD44 (show CD44 Antibodies) or hyaluronan, and can offer a rapid cellular response to injury and inflammation.

  6. Among the genes affected by FAK (show PTK2 Antibodies) or HAS3 (show HAS3 Antibodies) inhibition were genes, playing role in apoptosis, cell cycle regulation, adhesion, transcription, heatshock and WNT (show WNT2 Antibodies) pathways.

  7. Inverse expression of hyaluronidase 2 (show HYAL2 Antibodies) and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

  8. aberrant intronic HAS1 splicing in multiple myeloma patients may rely on intronic HAS1 deletions and mutations that are frequent in MM patients but absent from healthy donors

  9. TGF-beta1 (show TGFB1 Antibodies) up-regulation of HAS1 transcription was mediated via Smad3 (show SMAD3 Antibodies) but not Smad2 (show SMAD2 Antibodies), while HAS1 induction by IL-1beta (show IL1B Antibodies) was Sp3 (show SP3 Antibodies), not Sp1 (show PSG1 Antibodies), dependent.

  10. Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc (show B3GNT3 Antibodies) concentration than HAS2 (show HAS2 Antibodies) and HAS3 (show HAS3 Antibodies)

Pig (Porcine) Hyaluronan Synthase 1 (HAS1) interaction partners

  1. The HA concentration in follicular fluids increased during atresia and HAS1 may be the dominant HAS protein in theca cells to produce HA in pig ovaries.

Mouse (Murine) Hyaluronan Synthase 1 (HAS1) interaction partners

  1. HAS1 was significantly upregulated at the level of gene expression during muscle hypertrophy.

  2. analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 is expressed in preterm birth, while Has2 (show HAS2 Antibodies) is induced at term

  3. Selective loss of Has1 and Has3 (show HAS3 Antibodies) leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.

  4. repression of HA-accumulation by both COX-2 (show COX2 Antibodies) selective and non-selective COX (show CPOX Antibodies) inhibition implicates COX-2 (show COX2 Antibodies) in the regulation of HA synthesis via stimulation of HAS1 and HAS2 (show HAS2 Antibodies) expression in vivo

  5. Has-1 transduced ASMCs accumulated the greatest amount of HA containing ECM (show MMRN1 Antibodies) than the other transduced ASMCs.Confocal microscopy showed CD44 (show CD44 Antibodies) positive monocytes bound to hyaluronidase (show HAase Antibodies) sensitive ECM (show MMRN1 Antibodies) in has-1 transduced ASMCs.

HAS1 Antigen Profile

Protein Summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

Gene names and symbols associated with HAS1

  • hyaluronan synthase 1 (has1) antibody
  • hyaluronan synthase 1 (HAS1) antibody
  • hyaluronan synthase 1 (Has1) antibody
  • hyaluronan synthase1 (Has1) antibody
  • dg42 antibody
  • HAS antibody
  • shas1 antibody
  • Xhas1 antibody

Protein level used designations for HAS1

hyaluronan synthase 1 , HA synthase 1 , Hyaluronate synthase 1 , Hyaluronic acid synthase 1 , huHAS1 , hyaluronate synthase 1 , hyaluronic acid synthase 1 , xHAS1

GENE ID SPECIES
403130 Danio rerio
719773 Macaca mulatta
100028664 Monodelphis domestica
100126662 Papio anubis
100145746 Xenopus (Silurana) tropicalis
100598248 Nomascus leucogenys
282821 Rattus norvegicus
3036 Homo sapiens
611700 Canis lupus familiaris
100191062 Sus scrofa
282820 Bos taurus
379383 Xenopus laevis
15116 Mus musculus
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