HAS1 antibody
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- Target See all HAS1 Antibodies
- HAS1 (Hyaluronan Synthase 1 (HAS1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HAS1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human HAS1 expressed in E. coli.
- Clone
- 3-00E-10
- Isotype
- IgG1
- Top Product
- Discover our top product HAS1 Primary Antibody
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).
: "Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia." in: Clinical lymphoma, Vol. 5, Issue 4, pp. 253-6, (2005) (PubMed).
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Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).
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- Target
- HAS1 (Hyaluronan Synthase 1 (HAS1))
- Alternative Name
- HAS1 (HAS1 Products)
- Synonyms
- dg42 antibody, Xhas1 antibody, HAS antibody, shas1 antibody, hyaluronan synthase 1 antibody, hyaluronan synthase 1 S homeolog antibody, has1 antibody, HAS1 antibody, Has1 antibody, has1.S antibody
- Background
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Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
Aliases: HAS, HAS1
- Molecular Weight
- 65 kDa
- Gene ID
- 3036
- HGNC
- 3036
- Pathways
- Glycosaminoglycan Metabolic Process
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