HAS1 antibody (AA 80-390)

Catalog No. ABIN6141611

The Rabbit Polyclonal anti-HAS1 antibody is suitable to detect HAS1 in samples from Human. It has been validated for WB.

Quick Overview for HAS1 antibody (AA 80-390) (ABIN6141611)

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HAS1 Antibody

Binding Specificity: AA 80-390

Sequence: RVAAAARGPL DAATARSVAL TISAYQEDPA YLRQCLASAR ALLYPRARLR VLMVVDGNRA EDLYMVDMFR EVFADEDPAT YVWDGNYHQP WEPAAAGAVG AGAYREVEAE DPGRLAVEAL VRTRRCVCVA QRWGGKREVM YTAFKALGDS VDYVQVCDSD TRLDPMALLE LVRVLDEDPR VGAVGGDVRI LNPLDSWVSF LSSLRYWVAF NVERACQSYF HCVSCISGPL GLYRNNLLQQ FLEAWYNQKF LGTHCTFGDD RHLTNRMLSM GYATKYTSRS RCYSETPSSF LRWLSQQTRW SKSYFREWLY N

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-390 of human HAS1 (NP_001514.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HAS1

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Alternative Name: HAS1

Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants.,HAS1,HAS,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Neuroscience,Stem Cells,Cardiovascular,Angiogenesis,Heart,Cardiogenesis,HAS1

Molecular Weight: 64 kDa

Gene ID: 3036

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process