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Hydroxyprostaglandin Dehydrogenase 15-(NAD) Proteins (HPGD)

HPGD encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. Additionally we are shipping HPGD Antibodies (135) and HPGD Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HPGD 15446 Q8VCC1
HPGD 79242 O08699
HPGD 3248 P15428
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Top HPGD Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$2,687.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,691.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,691.33
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,691.33
Details

HPGD Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

Top referenced HPGD Proteins

  1. Mouse (Murine) HPGD Protein expressed in Escherichia coli (E. coli) - ABIN2007937 : Patel, Funder, Challis et al.: Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast ... in The Journal of clinical endocrinology and metabolism 2003 (PubMed)
    Show all 3 references for ABIN2007937

  2. Human HPGD Protein expressed in Escherichia coli (E. coli) - ABIN2004084 : McKeown, Challis: Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. in The Journal of clinical endocrinology and metabolism 2003 (PubMed)
    Show all 3 references for ABIN2004084

  3. Human HPGD Protein expressed in Escherichia coli (E. coli) - ABIN667214 : Van Meir, Sangha, Walton, Matthews, Keirse, Challis: Immunoreactive 15-hydroxyprostaglandin dehydrogenase (PGDH) is reduced in fetal membranes from patients at preterm delivery in the presence of infection. in Placenta 1996 (PubMed)
    Show all 2 references for ABIN667214

  4. Human HPGD Protein expressed in Wheat germ - ABIN1307031 : Hughes, Otani, Yang, Newman, Yantiss, Altorki, Port, Yan, Markowitz, Mazumdar, Tai, Subbaramaiah, Dannenberg: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2009 (PubMed)

More Proteins for Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) Interaction Partners

Mouse (Murine) Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. 15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC (show FAM126A Proteins)) and in human HCC (show FAM126A Proteins) biopsies.

  2. Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.

  3. prostaglandin E synthase (show PTGES Proteins) (cPGES/p23 (show PTGES3 Proteins)) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).

  4. I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk (show GCK Proteins)-rs1 (show RS1 Proteins)) and downregulation of hydroxyprostaglandin dehydrogenase.

  5. OAT (show OAT Proteins)-PG is proposed to be involved in the local PGE (show LIPF Proteins)(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.

  6. novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression

  7. 15-Hydroxyprostaglandin dehydrogenase (show CBR1 Proteins) has a role in suppressing colon tumorigenesis

  8. The intrarenal distribution of 15-PGDH and its interactions with COX-2 suggest that differential regulation of COX-2 and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis.

Guinea Pig Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. Data indicate that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor TD88 could be a good effector on wound healing, especially in the aspects of prevention of scarring.

  2. The data indicate that decreased expression of 15-hydroxyprostaglandin dehydrogenase in the fetal membranes may contribute to the increase in intrauterine prostaglandin concentrations at term, stimulating the onset of labor.

Human Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. A common mutation and a novel mutation in HPGD gene were identified to be responsible for primary hypertrophic osteoarthropathy

  2. Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.

  3. Neoadjuvant chemotherapy could increase 15-PGDH expression in advanced gastric cancer patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to therapy.

  4. 15-PGDH mRNA levels were significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors.

  5. Omega-3 polyunsaturated fatty acids upregulate the expression of 15-PGDH by inhibiting miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-26b.

  6. Multiple drug resistance-associated protein (show ABCC1 Proteins) 4 (MRP4), prostaglandin transporter (PGT (show SLCO2A1 Proteins)), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.

  7. Loss of PGDH expression is associated with esophageal squamous cell carcinoma and adenocarcinoma.

  8. A single nucleotide polymorphism in the 3' untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene modifies mir (show MLXIP Proteins)-485-5p binding in breast cancer.

  9. Case Reports: novel 2-bp homozygous deletion was found in exon 3 (c.310-311delCT) of HPGD gene in the patients with Primary hypertrophic osteoarthropathy.

  10. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity.

HPGD Protein Profile

Protein Summary

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HPGD

  • hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD)
  • hydroxyprostaglandin dehydrogenase 15-(NAD) (hpgd)
  • 15-hydroxyprostaglandin dehydrogenase (pgdh)
  • 15-hydroxyprostaglandin dehydrogenase (PTRG_03214)
  • 15-hydroxyprostaglandin dehydrogenase (VDBG_09957)
  • hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd)
  • 15-PGDH protein
  • AV026552 protein
  • MGC79454 protein
  • MGC80546 protein
  • PGDH protein
  • PGDH1 protein
  • PHOAR1 protein
  • SDR36C1 protein

Protein level used designations for HPGD

15-hydroxyprostaglandin dehydrogenase , hydroxyprostaglandin dehydrogenase 15-(NAD) , 15-hydroxyprostaglandin dehydrogenase [NAD(+)] , PGDH , prostaglandin dehydrogenase 1 , 15-PGDH , NAD-dependent 15-hydroxyprostaglandin dehydrogenase , 15-hydroxyprostaglandin dehydrogenase (NAD+) , NAD+-dependent 15-hydroxyprostaglandin dehydrogenase , short chain dehydrogenase/reductase family 36C, member 1 , NAD+ dependent 15-hydroxyprostaglandin dehydrogenase

GENE ID SPECIES
422567 Gallus gallus
446811 Xenopus laevis
461613 Pan troglodytes
486073 Canis lupus familiaris
493354 Xenopus (Silurana) tropicalis
100009687 Equus caballus
100156186 Sus scrofa
100172788 Pongo abelii
100196521 Salmo salar
6341441 Pyrenophora tritici-repentis Pt-1C-BFP
9531736 Verticillium alfalfae VaMs.102
15446 Mus musculus
79242 Rattus norvegicus
100135538 Cavia porcellus
3248 Homo sapiens
512259 Bos taurus
101112958 Ovis aries
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