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Hydroxysteroid (11-Beta) Dehydrogenase 1 Proteins (HSD11B1)

The protein encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. Additionally we are shipping HSD11B1 Antibodies (111) and HSD11B1 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSD11B1 3290 P28845
HSD11B1 15483 P50172
HSD11B1 25116 P16232
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Top HSD11B1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,759.17
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Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,768.33
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Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,768.33
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,768.33
Details

HSD11B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) Interaction Partners

Human Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. ins4436A in the HSD11B1 gene is associated with essential hypertension in a Polish population

  2. the availability of H6PDH determines the different direction of 11beta-HSD1 in liver and Leydig cells.

  3. we also found a significant difference between AA and AG genotype of rs6688832 and the AG genotype was associated with hyperandrogenism, but no statistical different distribution of polymorphism rs17368528 of H6PD and rs846908 of HSD11B1 were observed

  4. 11beta-HSD1 expressed in polyp-derived epithelial cells may be involved in the anti-inflammatory function of glucocorticoid in the treatment of nasal polyps, which contributes to increased levels of endogenous cortisol.

  5. Our work is one of the first comprehensive views of DNA methylation (show HELLS Proteins) and expression in the placenta for both HSD11B types 1 and 2, linking epigenetic alterations with the regulation of fetal stress and birth weight outcomes.

  6. Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 (show FKBP1A Proteins) and 11betaHSD1.

  7. Our results indicate that HSD11B1 polymorphisms may contribute toward the development of MetS in psychiatric patients treated with potential weight gain-inducing psychotropic drugs, but do not play a significant role in the general population

  8. This review describes the body of work performed over the past decade detailing the importance and regulation of HSD11B1 in humans, and its relevance to metabolic disease. [review]

  9. Promoter SNPs of the HSD11B1 gene might exert a potential genetic protective role against the development of PCOS, possibly via their beneficial effect on carbohydrate homeostasis due to facilitation of insulin (show INS Proteins) efflux from pancreatic beta-cells.

  10. Skeletal muscle 11beta-HSD1 is up-regulated with age in women and is associated with reduced grip strength, insulin (show INS Proteins) resistance, and an adverse body composition profile.

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. Results describe the cloning, sequence and expression of 11beta-hydroxysteroid dehydrogenase type 1 from pig testis.

  2. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

  3. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B1.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. HSD11B1 was localized in mature adipocytes of early lactating cows, indicating that circulating glucocorticoids promote effects other than differentiation.

  2. investigation of gene expression for 11HSD1, 11HSD2 (show HSD11B2 Proteins), and glucocorticoid receptor (show NR3C1 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of 11HSD1 is developmentally regulated in maturing follicles

  3. PGF2alpha but not PGE2 increases HSD11B1 bioactivity and protein expression by stimulating a posttranscriptional mechanism in stromal cells.

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. Our results demonstrate an inhibitory effect of IGF-I (show IGF1 Proteins) on 11beta-HSD1 expression and activity within the pancreatic islets, which may mediate part of the IGF-I (show IGF1 Proteins) effects on cell proliferation, survival and insulin (show INS Proteins) secretion

  2. Data indicate that 11beta-HSD1 activity contributes substantially to diurnal and stress-induced increases in hippocampal CORT (show CORT Proteins) levels.

  3. Dynamic increases in hippocampal 11b-HSD1 (show SPAG8 Proteins) regenerated CORT (show CORT Proteins) levels during learning and retrieval play a key role in age- and stress-associated impairments of spatial memory.

  4. Data suggest that Hsd11b1 expression is up-regulated in white adipose tissues of obese mice; this induction of Hsd11b1 appears to reduce mitochondrial respiration and adiponectin (show ADIPOQ Proteins) synthesis in hypertrophic adipocytes.

  5. Data suggest that Gh (growth hormone (show GH1 Proteins)) represses H6pd (hexose-6-phosphate dehydrogenase) through locally produced Igf1 (insulin-like growth factor 1 (show IGF1 Proteins)); Gh directly represses Hsd11b1 mRNA rather than acting via Igf1 (show IGF1 Proteins) receptor.

  6. Elevated adipose 11beta-HSD1 expression may contribute to glucocorticoid-induced insulin (show INS Proteins) resistance and adipolysis.

  7. 11beta-HSD1, particularly in adipose tissue, is key to the development of the adverse metabolic profile associated with circulating glucocorticoid excess

  8. The possibility of a vicious circle of glucocorticoids signals via 11beta-HSD1 up-regulation in adipose tissues, contributing to deterioration of glucose metabolism to result in diabetes.

  9. Elevated hepatic 11betaHSD1 is an important contributor to early insulin (show INS Proteins) resistance and dyslipidemia in uremia.

  10. TNFalpha (show TNF Proteins)-mediated Hsd11b1 binding of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) is associated with suppression of 11beta-HSD1 in muscle cells.

HSD11B1 Protein Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with HSD11B1

  • hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1)
  • Corticosteroid 11-beta-dehydrogenase isozyme 1-like (LOC100342395)
  • hydroxysteroid (11-beta) dehydrogenase 1 (hsd11b1)
  • hydroxysteroid (11-beta) dehydrogenase 1 (Hsd11b1)
  • hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1)
  • 11-beta-HSD1 protein
  • 11-DH protein
  • CORTRD2 protein
  • HDL protein
  • hsd11 protein
  • hsd11b protein
  • HSD11L protein
  • LRRGT00065 protein
  • SDR26C1 protein

Protein level used designations for HSD11B1

11-beta-hydroxysteroid dehydrogenase 1 , hydroxysteroid 11-beta dehydrogenase 1 , hydroxysteroid (11-beta) dehydrogenase 1 , corticosteroid 11-beta-dehydrogenase isozyme 1 , short chain dehydrogenase/reductase family 26C, member 1 , 11-DH , 11-beta-HSD1 , 11-beta-hydroxysteroid dehydrogenase type 1 , 11-beta hydroxysteroid dehydrogenase , 11 beta-hydroxysteroid dehydrogenase type 1 , 7-alpha-HCD , 7-alpha-hydroxycholesterol dehydrogenase , 11beta-HSD-1 , 11beta-HSD1A , 11beta-hydroxysteroid dehydrogenase type 1 , Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A) , cortocosteroid 11-beta dehydrogenase , hydroxysteroid dehydrogenase, 11 beta type 1

GENE ID SPECIES
457698 Pan troglodytes
574322 Macaca mulatta
419861 Gallus gallus
100342395 Oryctolagus cuniculus
3290 Homo sapiens
443409 Ovis aries
379497 Xenopus laevis
449023 Canis lupus familiaris
397480 Sus scrofa
282589 Bos taurus
101835279 Mesocricetus auratus
15483 Mus musculus
25116 Rattus norvegicus
100135542 Cavia porcellus
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