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ISG15 Ubiquitin-Like Modifier Proteins (ISG15)

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Antibodies (120) and ISG15 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
Rat ISG15 ISG15 298693  
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Top ISG15 Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 1 mg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human CaM 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Mouse GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,339.33
Details
HOST_Escherichia coli (E. coli) Mouse DYKDDDDK Tag   50 μg Log in to see 3 to 4 Days
$190.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$273.57
Details

ISG15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , , , , ,
Mouse (Murine)
, ,

Top referenced ISG15 Proteins

  1. Human ISG15 Protein expressed in Escherichia coli (E. coli) - ABIN2005319 : Loeb, Haas: The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. in The Journal of biological chemistry 1992 (PubMed)
    Show all 5 references for ABIN2005319

  2. Human ISG15 Protein expressed in Escherichia coli (E. coli) - ABIN1047870 : Blomstrom, Fahey, Kutny, Korant, Knight: Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence. in The Journal of biological chemistry 1986 (PubMed)
    Show all 3 references for ABIN1047870

  3. Human ISG15 Protein expressed in Escherichia coli (E. coli) - ABIN666864 : Andersen, Hassel: The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe? in Cytokine & growth factor reviews 2006 (PubMed)
    Show all 2 references for ABIN666864

More Proteins for ISG15 Ubiquitin-Like Modifier (ISG15) Interaction Partners

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. NSP2 (show RTN2 Proteins) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  2. Results report identification and cloning of the ISG15 and ISG43 (show USP18 Proteins) genes in pig.

Human ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Data show the induction of signal transducer and activator of transcription (STAT)1 (show STAT1 Proteins) and IFN-stimulated gene 15 protein (ISG15) in Rickettsia conorii-infected human umbilical vein endothelial cells (HUVECs).

  2. ISG15 is elevated in viremic HIV-1 patients and is associated with high TRAIL and IDO (show IDO1 Proteins) levels.

  3. ISG15 might serve as a novel prognostic biomarker in drinkers with esophageal squamous cell cancer

  4. Cellular ubiquitin is a substrate of ISG15 and Lys (show LYZ Proteins) 29 on ubiquitin is the major ISG15 acceptor site.

  5. Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon (show IFNA Proteins) inducible protein ISG15.

  6. The inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to substrates by HERC5 (show HERC5 Proteins).

  7. These data reveal a previously uncharacterized ISG15-dependent restriction of Listeria infection, reinforcing the view that ISG15 is a key component of the innate immune response.

  8. that ISGylation of BECN1 (show BECN1 Proteins) at Lys117, as well as Lys263, Lys265, and Lys266 serve an important role in negative regulation of intracellular processes including autophagy

  9. free ISG15 may have antitumor and immunoregulatory function in vivo in breast cancer

  10. Propose that Isg15-dependent degradation of p53 (show TP53 Proteins) represents an alternative mechanism of controlling p53 (show TP53 Proteins) protein levels, and, thus, it is an attractive pathway for drug discovery.

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  2. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  3. Kruppel-like factor 9 (KLF9 (show KLF9 Proteins)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

  4. Propose that Isg15-dependent degradation of p53 (show TP53 Proteins) represents an alternative mechanism of controlling p53 (show TP53 Proteins) protein levels, and, thus, it is an attractive pathway for drug discovery.

  5. Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.

  6. Enhanced resistance upon influenza B infection in USP18 (show USP18 Proteins)(C61A/C61A (show BRCC3 Proteins)) mice was completely reversed in USP18 (show USP18 Proteins)(C61A/C61A (show BRCC3 Proteins)) mice, which additionally lack ISG15, providing evidence that the observed reduction in viral titers is ISG15 dependent

  7. Authors found that ISG15 protects mice from influenza A virus and Sendai virus induced lethality by a conjugation-dependent mechanism in both of these models.

  8. study demonstrated that ISG15 had an anti-apoptotic effect on the beta cell line MIN6; conclusion is consistent with previous reports that ISG15 has a protective role

  9. The ISG15 conjugation system represents a critical innate response mechanism in cardiomyocytes to fight the battle against invading pathogens, limiting inflammatory cardiomyopathy, heart failure, and death.

  10. ISG15 does not appear to play a key role in IFN-beta (show IFNB1 Proteins)-mediated C2C12 myoblast cell fusion

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Data indicate that the expression profiles of ISG15, MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.

  2. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  3. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  4. interferon-stimulated protein (show ISG20 Proteins)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  5. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.

ISG15 Protein Profile

Protein Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Gene names and symbols associated with ISG15

  • ISG15 ubiquitin-like modifier (isg15)
  • ISG15 ubiquitin-like modifier (ISG15)
  • ISG15 ubiquitin-like modifier (Isg15)
  • G1p2 protein
  • hUCRP protein
  • IFI15 protein
  • IGI15 protein
  • IP17 protein
  • Irfp protein
  • ISG15 protein
  • si:rp71-1c23.2 protein
  • UCRP protein
  • zfISG15 protein

Protein level used designations for ISG15

ISG15 ubiquitin-like modifier , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , si:rp71-1c23.2 , zfISG15 , ubiquitin-like protein ISG15 , interferon-induced 17 kDa protein , interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , boUCRP , interferon-stimulated gene product 17

GENE ID SPECIES
286744 Danio rerio
465390 Pan troglodytes
479575 Canis lupus familiaris
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100294592 Ovis aries
9636 Homo sapiens
100038882 Mus musculus
281871 Bos taurus
298693 Rattus norvegicus
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