ISG15 Ubiquitin-Like Modifier Proteins (ISG15)

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Antibodies (150) and ISG15 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
Rat ISG15 ISG15 298693  
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Top ISG15 Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Human GST tag ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag) 50 μg Log in to see 13 to 16 Days
$242.00
Details
Escherichia coli (E. coli) Human Un-conjugated 1 mg Log in to see 20 to 21 Days
$206.80
Details
Escherichia coli (E. coli) Human CaM 100 μg Log in to see 15 to 19 Days
$242.00
Details
Escherichia coli (E. coli) Mouse GST tag   50 μg Log in to see 11 Days
$341.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$154.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$125.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details

ISG15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , , , , , , , , ,
Mouse (Murine)
, ,

More Proteins for ISG15 Ubiquitin-Like Modifier (ISG15) Interaction Partners

Human ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. findings revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C-terminal domain; structure of MERS-CoV PLpro was solved to 2.4 A in complex with the C-terminal domain of hISG15; structure of MERS-CoV PLpro in complex with this domain exposed the interface between these two entities

  2. Our study demonstrates a protumor role of ISG15, and suggests that ISG15 is a prognostic predictor and a potential therapeutic target for nasopharyngeal carcinoma

  3. Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin which increases its ubiquitin E3 ligase activity.

  4. Extracellular ISG15 signals cytokine secretion through the LFA-1 (show ITGAL Proteins) integrin receptor (CD11a (show ITGAL Proteins)/CD18 (show ITGB2 Proteins)) in natural killer cells.

  5. Results suggest that unconjugated ISG15 affects the functions of HCV NS5A through protein-protein interaction.

  6. This report demonstrates that ISG15 induced by Hepatitis E virus replication in Huh7-S10 (show L1CAM Proteins)-3 human liver cells plays an immunomodulatory role by negatively regulating type I Interferon (show IFNA Proteins) signaling and, thus, Hepatitis E virus sensitivity to type I Interferon (show IFNA Proteins).

  7. epletion of either ISG15 or UBE2L6/UBCH8 (show UBE2L6 Proteins) resulted in enhanced endogenous autophagic flux.

  8. unlike ISG15, ubiquitin and FAT10 (show UBD Proteins) are conjugated to a similar degree to newly translated and pre-existing proteins.

  9. This paper shows that ISG15 directly regulates Human Cytomegalovirus replication and that its accumulation restricts productive virus growth.

  10. The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.

  2. ISG15, UBE1l (show UBA7 Proteins) and UBCH8 (show UBE2E2 Proteins) genes are significantly upregulated in the artificially inseminated pregnant cows.

  3. Data indicate that the expression profiles of ISG15, MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.

  4. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  5. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  6. interferon-stimulated protein (show ISG20 Proteins)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  7. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. NSP2 (show RTN2 Proteins) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  2. Results report identification and cloning of the ISG15 and ISG43 (show USP18 Proteins) genes in pig.

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Extracellular ISG15 signals cytokine secretion through the LFA-1 (show ITGAL Proteins) integrin receptor (CD11a (show ITGAL Proteins)/CD18 (show ITGB2 Proteins)) in natural killer cells.

  2. results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.

  3. Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice

  4. ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

  5. USP18 (show USP18 Proteins)'s ISG15 specificity is mediated by a small interaction interface.

  6. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  7. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  8. Kruppel-like factor 9 (KLF9 (show KLF9 Proteins)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

  9. Propose that Isg15-dependent degradation of p53 (show TP53 Proteins) represents an alternative mechanism of controlling p53 (show TP53 Proteins) protein levels, and, thus, it is an attractive pathway for drug discovery.

  10. Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.

Horse (Equine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. The expression of interferon-stimulated protein 15 kDa (ISG15) during pregnancy is described.[ISG15]

ISG15 Protein Profile

Protein Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Gene names and symbols associated with ISG15

  • ISG15 ubiquitin-like modifier (ISG15)
  • ISG15 ubiquitin-like modifier (isg15)
  • ISG15 ubiquitin-like modifier (Isg15)
  • G1p2 protein
  • hUCRP protein
  • IFI15 protein
  • IGI15 protein
  • IP17 protein
  • Irfp protein
  • ISG15 protein
  • ISG17 protein
  • ISG17/UCRP protein
  • si:rp71-1c23.2 protein
  • UCRP protein

Protein level used designations for ISG15

interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , ubiquitin-like protein ISG15 , boUCRP , interferon-stimulated gene product 17 , ISG15 ubiquitin-like modifier , si:rp71-1c23.2 , zfISG15 , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , interferon-induced 17 kDa protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , interferon stimulated gene 17 , interferon-stimulated protein 17/ubiquitin cross-reactive protein

GENE ID SPECIES
9636 Homo sapiens
281871 Bos taurus
465390 Pan troglodytes
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100038882 Mus musculus
298693 Rattus norvegicus
100855667 Canis lupus familiaris
100354504 Oryctolagus cuniculus
443057 Ovis aries
102169982 Capra hircus
100066364 Equus caballus
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