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The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Antibodies (149) and ISG15 Kits (28) and many more products for this protein.
Showing 10 out of 35 products:
Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.
NSP2 (show RTN2 Proteins) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.
Results report identification and cloning of the ISG15 and ISG43 (show USP18 Proteins) genes in pig.
This report demonstrates that ISG15 induced by Hepatitis E virus replication in Huh7-S10 (show L1CAM Proteins)-3 human liver cells plays an immunomodulatory role by negatively regulating type I Interferon (show IFNA Proteins) signaling and, thus, Hepatitis E virus sensitivity to type I Interferon (show IFNA Proteins).
epletion of either ISG15 or UBE2L6/UBCH8 (show UBE2L6 Proteins) resulted in enhanced endogenous autophagic flux.
unlike ISG15, ubiquitin and FAT10 (show UBD Proteins) are conjugated to a similar degree to newly translated and pre-existing proteins.
This paper shows that ISG15 directly regulates Human Cytomegalovirus replication and that its accumulation restricts productive virus growth.
The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.
These data indicate that hepatic expression of PSMA6 (show PSMA6 Proteins), which is upregulated during viral hepatitis, likely depends on TLR3 (show TLR3 Proteins) activation and, that PSMA6 (show PSMA6 Proteins) affects the expression of immunoregulatory ISG15, a proviral factor in the pathogenesis of hepatitis C virus infection.
ISG15 dysregulation may be involved in the pathogenesis of glomerular inflammation
This study shows that interferon (show IFNA Proteins)-stimulated gene 15 (ISG15) lowers Human respiratory syncytial virus growth through protein ISGylation.
Data show the induction of signal transducer and activator of transcription (STAT)1 (show STAT1 Proteins) and IFN-stimulated gene 15 protein (ISG15) in Rickettsia conorii-infected human umbilical vein endothelial cells (HUVECs).
ISG15 is elevated in viremic HIV-1 patients and is associated with high TRAIL and IDO (show IDO1 Proteins) levels.
Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice
ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.
USP18 (show USP18 Proteins)'s ISG15 specificity is mediated by a small interaction interface.
Posttranslational protein modification by ISG15 plays an important role in antiviral defense
These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.
Kruppel-like factor 9 (KLF9 (show KLF9 Proteins)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.
Propose that Isg15-dependent degradation of p53 (show TP53 Proteins) represents an alternative mechanism of controlling p53 (show TP53 Proteins) protein levels, and, thus, it is an attractive pathway for drug discovery.
Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.
Enhanced resistance upon influenza B infection in USP18 (show USP18 Proteins)(C61A/C61A (show BRCC3 Proteins)) mice was completely reversed in USP18 (show USP18 Proteins)(C61A/C61A (show BRCC3 Proteins)) mice, which additionally lack ISG15, providing evidence that the observed reduction in viral titers is ISG15 dependent
Authors found that ISG15 protects mice from influenza A virus and Sendai virus induced lethality by a conjugation-dependent mechanism in both of these models.
ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.
ISG15, UBE1l (show UBA7 Proteins) and UBCH8 (show UBE2E2 Proteins) genes are significantly upregulated in the artificially inseminated pregnant cows.
Data indicate that the expression profiles of ISG15, MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.
ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.
ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy
interferon-stimulated protein (show ISG20 Proteins)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells
rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
ISG15 ubiquitin-like modifier
, interferon stimulated gene, 15 kDa
, interferon, alpha-inducible protein
, ubiquitin-like protein ISG15
, interferon-induced 17 kDa protein
, interferon, alpha-inducible protein (clone IFI-15K)
, interferon-induced 17-kDa/15-kDa protein
, interferon-stimulated protein, 15 kDa
, ubiquitin cross-reactive protein
, interferon-stimulated protein 15
, interferon-induced 15 kDa protein
, interferon-induced 15-KDa protein
, interferon-stimulated protein (15 kDa)
, interferon-stimulated gene product 17