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Indoleamine 2,3-Dioxygenase 1 Proteins (IDO1)

IDO1 encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. Additionally we are shipping Indoleamine 2,3-Dioxygenase 1 Antibodies (182) and Indoleamine 2,3-Dioxygenase 1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDO1 3620 P14902
IDO1 15930 P28776
IDO1 66029 Q9ERD9
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Top Indoleamine 2,3-Dioxygenase 1 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$316.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag   50 μg Log in to see 5 to 8 Days
$488.25
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,129.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Indoleamine 2,3-Dioxygenase 1 Proteins

  1. Human IDO1 Protein expressed in Escherichia coli (E. coli) - ABIN2004475 : Barnes, Stephenson, Tooze, Doody: Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaction Partners

Cow (Bovine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. Differential expression of CD25 (show IL2RA Proteins) and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.

  2. IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.

  3. INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs

Rhesus Monkey Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta (show TGFB1 Proteins) and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Human Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. Results suggest Withaferin A (WA) as a valuable small ligand molecule with strong binding affinity toward indoleamine 2,3-dioxygenase (IDO).

  2. Our results imply the probability of involvement of IDO in development of tolerance process, and we presume that high IDO activity is associated with nonresponsiveness to food allergens despite allergen sensitization.

  3. IDO, through GCN2 (show EIF2AK4 Proteins) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2 (show GLS2 Proteins)

  4. ISG15 (show ISG15 Proteins) is elevated in viremic HIV-1 patients and is associated with high TRAIL and IDO levels.

  5. IDO1 expression and activity in LC seem to be involved in the pathophysiology of EH in AD and could represent a predictive biomarker for patients with risk to develop EH and other viral complications.

  6. slows down viral replication during Hepatitis C infection; inhibits CD4 (show CD4 Proteins)-T cells proliferation

  7. MT has potentiating effect in TGF-beta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins), independently of IDO. This nonimmunological effect of MT should be considered if IDO is the target to avoid immune escape in bladder cancer

  8. We conclude that autophagy, but not IDO and IFNgamma responsiveness, is dispensable for MSC's immunosuppressive properties. MSCs from CD subjects are functionally analogous to those of healthy individuals

  9. IDO expression was increased in acute phase multiple sclerosis compared to patients in stable phase.

  10. the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. Severity of sodium dodecyl sulfate-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88 (show MYD88 Proteins)-NF-kB transcriptional networks.

  2. IDO1 deficiency does not affect inflammation in Systemic Juvenile Idiopathic Arthritis, Secondary Hemophagocytic Lymphohistiocytosis and a T cell-triggered cytokine release model.

  3. Data indicate that indolamine-2,3-dioxygenase (IDO) and Fibroblast activation protein alpha (show FAP Proteins) (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.

  4. Increased expression of IDO in liver cell adenomas compared to the surrounding normal tissue may create a microenvironment that promotes the progression of HCC (show FAM126A Proteins) by suppressing the proliferation of cytotoxic T lymphocytes and enhancing Tregs.

  5. Chimeric vaccine stimulation of human dendritic cell IDO1 occurs via the non-canonical NF-kappaB (show NFKB1 Proteins) pathway.

  6. Absence of Ido1 protects against atherosclerosis through increase of Il10 (show IL10 Proteins).

  7. the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells.

  8. TNF-alpha (show TNF Proteins) mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress.

  9. Experimental hemophilic mouse models with or without functional IDO1 revealed that tryptophan metabolites, which result from IDO1 activity, prevent generation of anti-FVIII (show F8 Proteins) antibodies.

  10. Data indicate indoleamine 23-dioxygenase 1 IDO1 induction in B cells as a negative regulatory mechanism of the T Cell-independent antigens (TI) humoral immune response.

Pig (Porcine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

Indoleamine 2,3-Dioxygenase 1 (IDO1) Protein Profile

Protein Summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Gene names and symbols associated with IDO1

  • indoleamine 2,3-dioxygenase 1 (IDO1)
  • indoleamine 2,3-dioxygenase 1 (ido1)
  • indoleamine 2,3-dioxygenase 1 (Ido1)
  • indoleamine 2,3-dioxygenase 1-like (LOC100050681)
  • cd107b protein
  • Ido protein
  • IDO-1 protein
  • IDO1 protein
  • Indo protein

Protein level used designations for IDO1

indoleamine-pyrrole 2,3 dioxygenase , indoleamine 2,3-dioxygenase 2 , proto-IDO , putative indoleamine 2,3-dioxygenase , indoleamine 2,3-dioxygenase 1 , indolamine 2,3 dioxygenase , indole 2,3-dioxygenase , indoleamine-pyrrole 2,3-dioxygenase , IDO-1 , indoleamine 23-dioxygenase

GENE ID SPECIES
506281 Bos taurus
100037099 Xenopus laevis
100086385 Ornithorhynchus anatinus
448488 Xenopus (Silurana) tropicalis
464134 Pan troglodytes
571967 Danio rerio
574370 Macaca mulatta
100032999 Monodelphis domestica
100196903 Ovis aries
3620 Homo sapiens
15930 Mus musculus
66029 Rattus norvegicus
475574 Canis lupus familiaris
100519877 Sus scrofa
100050681 Equus caballus
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