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Indoleamine 2,3-Dioxygenase 1 Proteins (IDO1)

IDO1 encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. Additionally we are shipping Indoleamine 2,3-Dioxygenase 1 Antibodies (174) and Indoleamine 2,3-Dioxygenase 1 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDO1 3620 P14902
IDO1 15930 P28776
IDO1 66029 Q9ERD9
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Top Indoleamine 2,3-Dioxygenase 1 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$316.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag   50 μg Log in to see 5 to 8 Days
$488.25
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,129.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$158.89
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$285.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Indoleamine 2,3-Dioxygenase 1 Proteins

  1. Human IDO1 Protein expressed in Escherichia coli (E. coli) - ABIN2004475 : Barnes, Stephenson, Tooze, Doody: Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaction Partners

Cow (Bovine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. Differential expression of CD25 (show IL2RA Proteins) and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.

  2. IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.

  3. INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs

Rhesus Monkey Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta (show TGFB1 Proteins) and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.

Human Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. Data show that in the absence of indoleamine 2,3-dioxygenase (IDO) inhibition, fatty acid oxidation increased along with increased activity of carnitine palmitoyltransferase I (CPT1 (show CPT1A Proteins)).

  2. High IDO1 expression is associated with cervical cancer.

  3. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma (show IFNG Proteins).

  4. These results indicate that the level of IDO expression may be associated with pregnancy-related complications, such as URSA, by affecting trophoblast cell proliferation and migration via the STAT3 (show STAT3 Proteins) signaling pathway.

  5. IDO is a potential prognostic biomarker for overall survival of patients with gastric adenocarcinoma after gastrectomy.

  6. IDO expressed by placenta cells can down-regulate NKp46 (show NCR1 Proteins) and NKG2D (show KLRK1 Proteins) expression and reduce cytotoxicity in NK cells, suggesting an important role for IDO in the maintenance of normal pregnancy

  7. Results suggest that IDO expression is implicated in immunosuppression and tumor progression in glioma cells; combining IDO inhibition with standard TMZ treatment could be an encouraging therapeutic strategy for patients with malignant glioma

  8. Results suggest Withaferin A (WA) as a valuable small ligand molecule with strong binding affinity toward indoleamine 2,3-dioxygenase (IDO).

  9. Our results imply the probability of involvement of IDO in development of tolerance process, and we presume that high IDO activity is associated with nonresponsiveness to food allergens despite allergen sensitization.

  10. IDO, through GCN2 (show EIF2AK4 Proteins) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2 (show GLS2 Proteins)

Mouse (Murine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

  1. This insight into IDO1's involvement in pro-tumorigenic inflammatory neovascularization may have important ramifications for IDO1 inhibitor development, not only in cancer where clinical trials are currently ongoing, but in other disease indications associated with neovascularization as well.

  2. Inhibition of IDO activity ameliorated Japanese encephalitis via enhancement of antiviral IFN-I/II innate and adaptive T-cell responses and increased central nervous system infiltration of peripheral leukocytes.

  3. Results suggest that IDO expression is implicated in immunosuppression and tumor progression in glioma cells; combining IDO inhibition with standard TMZ treatment could be an encouraging therapeutic strategy for patients with malignant glioma

  4. Data show that the expression of indoleamine 2, 3-dioxygenase 1 (IDO) was decreased after tumor cells were infected with Salmonella.

  5. Severity of sodium dodecyl sulfate-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88 (show MYD88 Proteins)-NF-kB transcriptional networks.

  6. IDO1 deficiency does not affect inflammation in Systemic Juvenile Idiopathic Arthritis, Secondary Hemophagocytic Lymphohistiocytosis and a T cell-triggered cytokine release model.

  7. Data indicate that indolamine-2,3-dioxygenase (IDO) and Fibroblast activation protein alpha (show FAP Proteins) (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.

  8. Increased expression of IDO in liver cell adenomas compared to the surrounding normal tissue may create a microenvironment that promotes the progression of HCC (show FAM126A Proteins) by suppressing the proliferation of cytotoxic T lymphocytes and enhancing Tregs.

  9. Chimeric vaccine stimulation of human dendritic cell IDO1 occurs via the non-canonical NF-kappaB (show NFKB1 Proteins) pathway.

  10. Absence of Ido1 protects against atherosclerosis through increase of Il10 (show IL10 Proteins).

Pig (Porcine) Indoleamine 2,3-Dioxygenase 1 (IDO1) interaction partners

Indoleamine 2,3-Dioxygenase 1 (IDO1) Protein Profile

Protein Summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Gene names and symbols associated with IDO1

  • indoleamine 2,3-dioxygenase 1 (IDO1)
  • indoleamine 2,3-dioxygenase 1 (ido1)
  • indoleamine 2,3-dioxygenase 1 (Ido1)
  • indoleamine 2,3-dioxygenase 1-like (LOC100050681)
  • cd107b protein
  • Ido protein
  • IDO-1 protein
  • IDO1 protein
  • Indo protein

Protein level used designations for IDO1

indoleamine-pyrrole 2,3 dioxygenase , indoleamine 2,3-dioxygenase 2 , proto-IDO , putative indoleamine 2,3-dioxygenase , indoleamine 2,3-dioxygenase 1 , indolamine 2,3 dioxygenase , indole 2,3-dioxygenase , indoleamine-pyrrole 2,3-dioxygenase , IDO-1 , indoleamine 23-dioxygenase

GENE ID SPECIES
506281 Bos taurus
100037099 Xenopus laevis
100086385 Ornithorhynchus anatinus
448488 Xenopus (Silurana) tropicalis
464134 Pan troglodytes
571967 Danio rerio
574370 Macaca mulatta
100032999 Monodelphis domestica
100196903 Ovis aries
3620 Homo sapiens
15930 Mus musculus
66029 Rattus norvegicus
475574 Canis lupus familiaris
100519877 Sus scrofa
100050681 Equus caballus
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