IDO1 Protein (His tag)
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- Target See all IDO1 Proteins
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IDO1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse IDO1/IDO Protein (His Tag)
- Sequence
- Met1-Pro407
- Characteristics
- Recombinant Mouse Indoleamine 2,3-dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Pro407 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product IDO1 Protein
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Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (His tag)
IDO1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (GST tag)IDO1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 304-403) protein (GST tag)IDO1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Indoleamine 2,3-Dioxygenase 1 (IDO1) (Active) proteinIDO1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % as determined by reducing SDS-PAGE. Active
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) protein (Strep Tag)Crystallography grade IDO1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-407) protein (Strep Tag)Crystallography grade IDO1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Indoleamine 2,3-Dioxygenase 1 (IDO1) (Active) protein (Myc-DYKDDDDK Tag)IDO1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Sodium Acetate, 150 mM NaCl and 20 % Glycerol, pH 4.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- Alternative Name
- IDO1/IDO (IDO1 Products)
- Synonyms
- INDO Protein, ido Protein, indo Protein, IDO Protein, cd107b Protein, IDO1 Protein, IDO-1 Protein, Ido Protein, Indo Protein, indoleamine 2,3-dioxygenase 1 Protein, indoleamine 2,3-dioxygenase 1 L homeolog Protein, indoleamine 2,3-dioxygenase 1-like Protein, IDO1 Protein, ido1.L Protein, ido1 Protein, Ido1 Protein, LOC100050681 Protein
- Background
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Background: Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
Synonym: Indole 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1, IDO-1, IDO1, IDO, INDO
- Molecular Weight
- 47.1 kDa
- UniProt
- P28776
- Pathways
- Activated T Cell Proliferation
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