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ITPA encodes an inosine triphosphate pyrophosphohydrolase. Additionally we are shipping Inosine Triphosphatase Antibodies (80) and Inosine Triphosphatase Proteins (22) and many more products for this protein.
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In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns.
The role of ITPase in mice is to exclude ITP from the ATP pool, and the main target substrate of this enzyme is rITP
Inosine triphosphatase polymorphism appeared to correlate with anemia in- cidence and RBV dose reduction during SOF (show GJA1 ELISA Kits)/RBV therapy.
Inosine triphosphatase (IPTA) rs1127354 variants but not rs7270101 were found in Chinese patients infected with chronic hepatitis C. IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the virological response to pegylated interferon (show IFNA ELISA Kits) plus ribavirin combination therapy in Chinese chronic hepatitis C virus-infected patients.
This study concluded that HIV-infection seems to be interfering with the nucleotide metabolism in leukocytes, including CD4 (show CD4 ELISA Kits) lymphocytes, by decreasing ITPase expression, independently of ITPA genotype.
A high prevalence of the ITPA polymorphisms associated with ribavirin-induced hemolytic anemia was found in Mexican Native Amerindians.
ITPA gene is associated with protection of anemia in patients with chronic hepatitis during antiviral therapy.
We concluded that ITPase activity plays an important function and that ATP concentration changes due to therapy are related to the Hb decreasing mechanism in the early period of therapy with HCV treatment
The aim of the study was to investigate frequencies of TPMT (show TPMT ELISA Kits) and ITPA polymorphisms in Lithuanian inflammatory bowel disease patients and analyze their association with azathioprine-related adverse events.
ITPA polymorphism was associated with RBV-induced anemia and thrombocytopenia in Egyptian patients with hepatitis C virus genotype 4 infection.
Hyperbilirubinemia develops at early time points after simeprevir administration in most cases and is dependent on the ITPA genotype.
Genetic variants in inosine triphosphatase (ITPA) gene have been linked to the haemolytic anaemia induced by peg (show PAEP ELISA Kits)-interferon (show IFNA ELISA Kits) and ribavirin treatment.
This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
inosine triphosphate pyrophosphatase
, inosine triphosphatase
, non-canonical purine NTP pyrophosphatase
, non-standard purine NTP pyrophosphatase
, nucleoside triphosphate pyrophosphatase
, nucleoside-triphosphate diphosphatase
, nucleoside-triphosphate pyrophosphatase
, inosine triphosphatase-A
, inosine triphosphate pyrophosphohydrolase
, putative oncogene protein HLC14-06-P
, inosine triphosphatase A
, Inosine triphosphatase
, Non-canonical purine NTP pyrophosphatase
, Non-standard purine NTP pyrophosphatase
, Nucleoside-triphosphate diphosphatase
, Nucleoside-triphosphate pyrophosphatase
, hypothetical protein